Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration.


OBJECTIVES:We evaluated the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and immunological measurements using blood samples from coke oven workers exposed to high and low PAH levels. METHODS:A population-based cross-sectional study was conducted from 2008-2009 with coke oven workers and steel-rolling workers as the exposed and control groups, respectively. Questionnaires on basic demographic information were administered. Personal breathing zone and urine samples were collected to quantify personal PAH intake and biological response doses. Immunological and cytokine parameters in serum were analysed. Urinary malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were analysed to determine oxidative stress induced by PAHs in relation to altered humoural immunological status. RESULTS:Mean levels of serum immunoglobulin A (IgA) and TNF-α were significantly increased in coke oven workers compared to steel-rolling workers who had no or minimal PAH exposure (p=0.0033 and p<0.0001, respectively). There were no significant differences in mean levels of IL-4 and IL-10 between coke oven workers and steel-rolling workers. Moderate activation of lipid peroxidation and oxidative damage as determined by plasma MDA and 8-OHdG levels were detected simultaneously with significant alterations in IgA and IgE levels. Multiple regression analyses demonstrated that PAHs with high molecular weights >252 (dibenzo(a,h)anthracene, benzo(a)pyrene, benzo(a)anthracene and/or indeno(1,2,3-cd)pyrene) correlated with IgA and IgE levels. CONCLUSIONS:This study showed that coke oven workers with chronic exposure to PAHs may develop immunological alteration. Oxidative stress and lipid peroxidation induced by PAHs may partly explain the alteration in immunological parameters.


Occup Environ Med


Jeng HA,Pan CH,Diawara N,Chang-Chien GP,Lin WY,Huang CT,Ho CK,Wu MT




Has Abstract


2011-09-01 00:00:00














  • Work-related musculoskeletal disorders among construction workers in the United States from 1992 to 2014.

    abstract:OBJECTIVES:Examine trends and patterns of work-related musculoskeletal disorders (WMSDs) among construction workers in the USA, with an emphasis on older workers. METHODS:WMSDs were identified from the 1992-2014 Survey of Occupational Injuries and Illnesses (SOII), and employment was estimated from the Current Populat...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Wang X,Dong XS,Choi SD,Dement J

    更新日期:2017-05-01 00:00:00

  • Fitness tests and occupational tasks of military interest: a systematic review of correlations.

    abstract::: Physically demanding occupations (ie, military, firefighter, law enforcement) often use fitness tests for job selection or retention. Despite numerous individual studies, the relationship of these tests to job performance is not always clear. : This review examined the relationship by aggregating previously reported...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Hauschild VD,DeGroot DW,Hall SM,Grier TL,Deaver KD,Hauret KG,Jones BH

    更新日期:2017-02-01 00:00:00

  • Validating self-reported mobile phone use in adults using a newly developed smartphone application.

    abstract:OBJECTIVE:Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS:107 participants (mean age 41.4 year...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Goedhart G,Kromhout H,Wiart J,Vermeulen R

    更新日期:2015-11-01 00:00:00

  • Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial.

    abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,随机对照试验


    authors: Wong JYY,Bassig BA,Seow WJ,Hu W,Ji BT,Blair A,Silverman DT,Lan Q

    更新日期:2017-06-01 00:00:00

  • Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers.

    abstract:OBJECTIVES:To examine if the occurrence of different cancers was increased among rubber workers, as the highest known exposures of humans to nitrosamines have occurred in the rubber industry. METHODS:A cohort of 8933 rubber workers (hired after 1 January 1950, still active or retired on 1 January 1981 and employed for...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Straif K,Weiland SK,Bungers M,Holthenrich D,Taeger D,Yi S,Keil U

    更新日期:2000-03-01 00:00:00

  • Exposure of Paris taxi drivers to automobile air pollutants within their vehicles.

    abstract:OBJECTIVES:To study the exposure of Parisian taxi drivers to automobile air pollutants during their professional activity. METHODS:A cross sectional study was carried out from 27 January to 27 March 1997, with measurements performed in the vehicles of 29 randomly selected drivers. Carbon monoxide (CO) content was meas...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Zagury E,Le Moullec Y,Momas I

    更新日期:2000-06-01 00:00:00

  • Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study.

    abstract:AIMS:To study the risk of childhood cancer in relation to parental occupation and related exposures. METHODS:Self reported occupational data from mothers and fathers of 3838 children with cancer and 7629 control children were analysed. Odds ratios were calculated for 31 "occupational groups" by parent, diagnostic grou...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: McKinney PA,Fear NT,Stockton D,UK Childhood Cancer Study Investigators.

    更新日期:2003-12-01 00:00:00

  • Respiratory symptoms and ventilatory function in confectionery workers.

    abstract::Respiratory symptoms and ventilatory capacity were studied in a group of 288 workers (259 women and 29 men) employed in a confectionery plant. A group of workers (96 women and 31 men) not exposed to confectionery manufacture were also studied as controls. The prevalence of chronic respiratory symptoms was higher in ex...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Zuskin E,Mustajbegovic J,Schachter EN,Kern J

    更新日期:1994-07-01 00:00:00

  • Exposure and dose modelling in occupational epidemiology.

    abstract::Complex and dynamic physiologic processes underlie the exposure-response relations that occupational and environmental epidemiologists study. Simple summary measures of exposure such as the average, cumulative exposure, or duration of exposure, can be applied suitably in exposure-response analyses in many instances. H...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Kriebel D,Checkoway H,Pearce N

    更新日期:2007-07-01 00:00:00

  • Association of hand and arm disinfection with asthma control in US nurses.

    abstract:OBJECTIVES:To investigate the association between occupational exposure to disinfectants/antiseptics used for hand hygiene and asthma control in nurses. METHODS:In 2014, we invited female nurses with asthma drawn from the Nurses' Health Study II to complete two supplemental questionnaires on their occupation and asthm...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Dumas O,Varraso R,Boggs KM,Descatha A,Henneberger PK,Quinot C,Speizer FE,Zock JP,Le Moual N,Camargo CA Jr

    更新日期:2018-05-01 00:00:00

  • Shift work and diabetes mellitus: a meta-analysis of observational studies.

    abstract:BACKGROUND:Observational studies suggest that shift work may be associated with diabetes mellitus (DM). However, the results are inconsistent. No systematic reviews have applied quantitative techniques to compute summary risk estimates. OBJECTIVES:To conduct a meta-analysis of observational studies assessing the assoc...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Gan Y,Yang C,Tong X,Sun H,Cong Y,Yin X,Li L,Cao S,Dong X,Gong Y,Shi O,Deng J,Bi H,Lu Z

    更新日期:2015-01-01 00:00:00

  • Mortality in uranium miners in west Bohemia: a long-term cohort study.

    abstract::A cohort of 4320 uranium miners in West Bohemia who started work at the mines during 1948 to 1959 and worked there for at least four years were followed up to the end of 1990 to determine cause specific mortality risks in relation to exposures in the mines. The miners had experienced high radon exposures, on average 2...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Tomásek L,Swerdlow AJ,Darby SC,Placek V,Kunz E

    更新日期:1994-05-01 00:00:00

  • Occupation and small bowel adenocarcinoma: a European case-control study.

    abstract:OBJECTIVES:Because of the rarity of small bowel adenocarcinoma (SBA), little is known about the aetiology of this disease. This study aimed to identify occupational clustering of cases SBA as a systematic approach to new hypotheses on the aetiology of this disease. METHODS:A European multicentre case-control study was...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究


    authors: Kaerlev L,Teglbjaerg PS,Sabroe S,Kolstad HA,Ahrens W,Eriksson M,González AL,Guénel P,Hardell L,Launoy G,Merler E,Merletti F,Suárez-Varela MM,Stang A

    更新日期:2000-11-01 00:00:00

  • Epidemiological study of hard metal asthma.

    abstract:OBJECTIVES:To elucidate factors contributing to hard metal asthma, the entire workforce of a corporation producing hard metal tools (n = 703) was examined. METHODS:The variables evaluated were the atopy reflected by immunoglobulin E (IgE) antibody against mite allergen, history of exposure to hard metal, smoking, conc...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Kusaka Y,Iki M,Kumagai S,Goto S

    更新日期:1996-03-01 00:00:00

  • Decade of variable progress: trends in fatal injury in workers in New Zealand from a national observational study.

    abstract:INTRODUCTION:Analyses of secular trends in work-related fatal injury in New Zealand have previously only considered the total working population, potentially hiding trends for important subgroups of workers. This paper examines trends in work-related fatalities in worker subgroups between 2005 and 2014 to indicate wher...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Lilley R,Maclennan B,Davie G,McNoe BM,Horsburgh S,Driscoll TR

    更新日期:2020-10-26 00:00:00

  • Interactions between physical and psychosocial risk factors at work increase the risk of back disorders: an epidemiological approach.

    abstract:OBJECTIVES:To investigate the possible interactions between physical and psychosocial risk factors at work that may be associated with self reported back disorders. METHODS:891 of 1514 manual workers, delivery drivers, technicians, customer services computer operators, and general office staff reported risk factors at...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Devereux JJ,Buckle PW,Vlachonikolis IG

    更新日期:1999-05-01 00:00:00

  • Prevalence and risk factors for latex allergy: a cross sectional study in a United Kingdom hospital.

    abstract:OBJECTIVES:To determine the prevalence and risk factors for symptoms related to gloves, and the relation between symptoms and immunological evidence of type 1 hypersensitivity to latex in a United Kingdom health care setting. METHODS:A cross sectional survey was carried out among 773 employees at a British hospital. A...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Smedley J,Jury A,Bendall H,Frew A,Coggon D

    更新日期:1999-12-01 00:00:00

  • Developments in reproductive risk management.

    abstract::Internationally, the debate on aims for occupational health policy is expanding its horizons. Included among the issues are not only concerns about safety for workers, but also for their progeny. Equality among the sexes is also assuming a prominent position. In several countries, existing and proposed legislation alr...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,评审


    authors: Stijkel A,van Dijk FJ

    更新日期:1995-05-01 00:00:00

  • Primary osteoarthritis and occupations: a national cross sectional survey of 10 412 symptomatic patients.

    abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Rossignol M,Leclerc A,Hilliquin P,Allaert FA,Rozenberg S,Valat JP,Avouac B,Coste P,Savarieau B,Fautrel B

    更新日期:2003-11-01 00:00:00

  • Hourly variation in fine particle exposure is associated with transiently increased risk of ST segment depression.

    abstract:OBJECTIVES:To evaluate whether hourly changes in fine particle (PM(2.5), diameter<2.5 microm) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. METHODS:41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. T...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Lanki T,Hoek G,Timonen KL,Peters A,Tiittanen P,Vanninen E,Pekkanen J

    更新日期:2008-11-01 00:00:00

  • Cancer incidence and specific occupational exposures in the Swedish leather tanning industry: a cohort based case-control study.

    abstract:OBJECTIVE:To study the effect on the incidence of cancer of exposure to chemicals handled in the leather tanning industry. MATERIALS AND METHODS:A case-control study was performed within a cohort of 2487 workers employed for at least six months during the period 1900-89 in three Swedish leather tanneries. 68 cancer ca...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Mikoczy Z,Schütz A,Strömberg U,Hagmar L

    更新日期:1996-07-01 00:00:00

  • Risk of leukaemia among children living near the Solway coast of Dumfries and Galloway Health Board area, Scotland, 1975-2002.

    abstract:OBJECTIVE:To investigate allegations of an excess risk of leukaemia among children living near the Solway Firth coast of Dumfries and Galloway Health Board area in Scotland, UK. METHODS:Incident cases of childhood leukaemia (International Classification of Diseases, 10th revision, C91-C95, patients aged 0-14 years) fo...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Stark JM,Black RJ,Brewster DH

    更新日期:2007-01-01 00:00:00

  • Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.

    abstract:OBJECTIVES:The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS:The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed t...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Sobus JR,Waidyanatha S,McClean MD,Herrick RF,Smith TJ,Garshick E,Laden F,Hart JE,Zheng Y,Rappaport SM

    更新日期:2009-02-01 00:00:00

  • Environmental factors associated with baseline and serial changes in fractional exhaled nitric oxide (FeNO) in spice mill workers.

    abstract:BACKGROUND:This study evaluated the determinants of high fractional exhaled nitric oxide (FeNO; >50 ppb) and serial changes in FeNO over a 24-hour period in spice mill workers at risk of work-related allergic respiratory disease and asthma. METHODS:A cross-sectional study of 150 workers used European Community Respira...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Van der Walt A,Baatjies R,Singh T,Jeebhay MF

    更新日期:2016-09-01 00:00:00

  • A cohort mortality study of lead-exposed workers in the USA, Finland and the UK.

    abstract:OBJECTIVES:To investigate further whether inorganic lead is a carcinogen among adults, or associated with increased blood pressure and kidney damage, via a large mortality study. METHODS:We conducted internal analyses via Cox regression of mortality in three cohorts of lead-exposed workers with blood lead (BL) data (U...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Steenland K,Barry V,Anttila A,Sallmén M,McElvenny D,Todd AC,Straif K

    更新日期:2017-11-01 00:00:00

  • Urinary excretion of platinum from platinum industry workers.

    abstract:OBJECTIVES:Assessment of level of exposure to platinum and platinum concentration in urine from platinum industry workers to evaluate internal exposures and excretion kinetics. METHODS:Platinum concentrations in urine samples from 34 workers were measured by adsorptive voltammetry after UV-photolysis. Morning and even...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Schierl R,Fries HG,van de Weyer C,Fruhmann G

    更新日期:1998-02-01 00:00:00

  • Sex ratio in offspring of those affected by dioxin and dioxin-like compounds: the Yusho, Seveso, and Yucheng incidents.

    abstract::Sex ratios in the offspring of those affected by dioxins or dioxin-like compounds have been reported from Seveso, Italy and Yucheng, Taiwan. The sex ratio of live births in Yusho, Japan after a similar accidental massive exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in 1968 are...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Yoshimura T,Kaneko S,Hayabuchi H

    更新日期:2001-08-01 00:00:00

  • Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data.

    abstract:OBJECTIVES:To review and summarise the epidemiological evidence on the carcinogenicity of occupational exposure to inorganic lead. METHODS:Case-control and cohort studies were reviewed and combined for meta-analysis. Fixed and random effect methods were used to estimate the summary effects. RESULTS:The combined resul...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析


    authors: Fu H,Boffetta P

    更新日期:1995-02-01 00:00:00

  • Cancer mortality in German carbon black workers 1976-98.

    abstract:BACKGROUND:Few studies have investigated cancer risks in carbon black workers and the findings were inconclusive. METHODS:The current study explores the mortality of a cohort of 1535 male German blue-collar workers employed at a carbon black manufacturing plant for at least one year between 1960 and 1998. Vital status...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Wellmann J,Weiland SK,Neiteler G,Klein G,Straif K

    更新日期:2006-08-01 00:00:00

  • Subjective symptoms, sleeping problems, and cognitive performance in subjects living near mobile phone base stations.

    abstract:BACKGROUND:The erection of mobile telephone base stations in inhabited areas has raised concerns about possible health effects caused by emitted microwaves. METHODS:In a cross-sectional study of randomly selected inhabitants living in urban and rural areas for more than one year near to 10 selected base stations, 365 ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章


    authors: Hutter HP,Moshammer H,Wallner P,Kundi M

    更新日期:2006-05-01 00:00:00