Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study.

Abstract:

BACKGROUND AND OBJECTIVE:Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. STUDY DESIGN/MATERIALS AND METHODS:We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm(2) and compare their cell viability using crystal fast violet assay. RESULTS:Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. CONCLUSION:A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.

journal_name

Lasers Surg Med

authors

Kah JC,Wan RC,Wong KY,Mhaisalkar S,Sheppard CJ,Olivo M

doi

10.1002/lsm.20674

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

584-9

issue

8

eissn

0196-8092

issn

1096-9101

journal_volume

40

pub_type

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