Interleukin (IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8.

abstract：:Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OP...

journal_title：Endocrinology

authors： Koide M,Kobayashi Y,Ninomiya T,Nakamura M,Yasuda H,Arai Y,Okahashi N,Yoshinari N,Takahashi N,Udagawa N

更新日期：2013-02-01 00:00:00

abstract：:In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...

journal_title：Endocrinology

authors： Chatzopoulou A,Roy U,Meijer AH,Alia A,Spaink HP,Schaaf MJ

更新日期：2015-05-01 00:00:00

abstract：:Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities. Furthermore, interactions between PTH and gp130 signaling have suggested that gp130 signaling might influence calcium homeostasis. We, therefore, examined th...

journal_title：Endocrinology

authors： Shin HI,Divieti P,Sims NA,Kobayashi T,Miao D,Karaplis AC,Baron R,Bringhurst R,Kronenberg HM

更新日期：2004-03-01 00:00:00

abstract：:Hypophysiotrophic neurons projecting to hypophyseal portal vessels in the median eminence of the hypothalamus maintain the operation of the master gland, the pituitary, by secreting releasing and release-inhibiting hormones into the bloodstream. LHRH, synthesized in neurons of the rat prosencephalon, is one of the key...

journal_title：Endocrinology

authors： Liposits Z,Reid JJ,Negro-Vilar A,Merchenthaler I

更新日期：1995-05-01 00:00:00

abstract：:Male and female Holtzman rats were raised from weaning on a vitamin D-deficient diet (-D). Control (+D) animals were raised on the same diet and orally given 70 IU vitamin D3 twice each week. Serum Ca levels fell at the same rate in -D males and females. In contrast, serum parathyroid hormone increased more rapidly in...

journal_title：Endocrinology

authors： Thomas ML,Forte LR

更新日期：1981-11-01 00:00:00

abstract：:Atrial Natriuretic Factor (ANF) has been demonstrated within the central nervous system (CNS), where it has been implicated in the regulation of blood pressure, fluid and electrolyte balance. To explore the effect of acute plasma vol expansion on the activation of CNS ANF, changes in ANF levels of CSF drawn from the c...

journal_title：Endocrinology

authors： Cameron VA,Espiner EA

更新日期：1990-11-01 00:00:00

abstract：:Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). However, the precise a...

journal_title：Endocrinology

authors： Weems PW,Witty CF,Amstalden M,Coolen LM,Goodman RL,Lehman MN

更新日期：2016-06-01 00:00:00

abstract：:The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. I...

journal_title：Endocrinology

authors： Moore XL,Tan SL,Lo CY,Fang L,Su YD,Gao XM,Woodcock EA,Summers RJ,Tregear GW,Bathgate RA,Du XJ

更新日期：2007-04-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors with established roles in cholesterol, lipid, and carbohydrate metabolism, although their function in adipocytes is not well characterized. Increased adipose tissue mass in obesity is associated with increased adipocyte lipolysis. Fatty acids (FA) generated by lipolysis c...

journal_title：Endocrinology

authors： Stenson BM,Rydén M,Steffensen KR,Wåhlén K,Pettersson AT,Jocken JW,Arner P,Laurencikiene J

更新日期：2009-09-01 00:00:00

abstract：:Pharmacological studies have suggested that the somatostatin (SS) receptor is heterogeneous and may exhibit subtypes selective for SS-14 and SS-28. Whether this heterogeneity can be explained by separate molecular forms of the receptor protein is unclear. In the present study, we have developed a novel photosensitive ...

journal_title：Endocrinology

authors： Srikant CB,Murthy KK,Escher EE,Patel YC

更新日期：1992-05-01 00:00:00

abstract：:Androgen regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) activities and accumulation of the mRNAs encoding these two enzymes in rodent kidney and accessory sex organs were studied. The ODC mRNA concentration and enzyme activity were increased by androgens in kidney, prosta...

journal_title：Endocrinology

authors： Crozat A,Palvimo JJ,Julkunen M,Jänne OA

更新日期：1992-03-01 00:00:00

abstract：:Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...

journal_title：Endocrinology

authors： Blackshear PJ,Nemenoff RA,Avruch J

更新日期：1984-01-01 00:00:00

abstract：:In the present study epididymal epithelium was immortalized in transgenic mice by expressing simian virus 40 T antigen under a 5.0-kb mouse glutathione peroxidase 5 promoter (GPX5-Tag1). Epididymal tumorigenesis was associated with an increase in c-Myc expression, and a marked decrease in B-Myc expression, with a 500-...

journal_title：Endocrinology

authors： Sipilä P,Shariatmadari R,Huhtaniemi IT,Poutanen M

更新日期：2004-01-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00

abstract：:Identification of RF-amide-related peptides (RFRP), as putative mammalian orthologs of the avian gonadotropin-inhibitory hormone, has drawn considerable interest on its potential effects and mechanisms of action in the control of gonadotropin secretion in higher vertebrates. Yet, these analyses have so far relied most...

journal_title：Endocrinology

authors： Pineda R,Garcia-Galiano D,Sanchez-Garrido MA,Romero M,Ruiz-Pino F,Aguilar E,Dijcks FA,Blomenröhr M,Pinilla L,van Noort PI,Tena-Sempere M

更新日期：2010-04-01 00:00:00

abstract：:The product of the ob/ob gene, leptin, is known to be able to exert a modulator, role on HPA axis function. The aim of the present study was to determine whether endogenous ACTH and glucocorticoids exert any regulatory effect on leptin secretion. For this purpose bilaterally adrenalectomized (ADX) or sham operated (Sh...

journal_title：Endocrinology

authors： Spinedi E,Gaillard RC

更新日期：1998-09-01 00:00:00

abstract：:A plasma fraction rich in thyroid hormone-binding globulin (hTBG, human thyropexin) was injected iv into rabbits in order to see whether thyroid hormone concentrations in plasma would increase by return of T3 and T4 from the extravascular space. For this purpose, both [125I]T3 and [131I]T4 were simultaneously injected...

journal_title：Endocrinology

authors： Wahl R,Schmidberger H,Fessler E,Heinzel W,Schenzle D,Bohner J,Kallee E

更新日期：1989-03-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis adapts to periods of chronic or repeated stress. We have now investigated whether there is any differential effect of repeated immobilization stress on CRH and arginine vasopressin (AVP) gene transcription in the hypothalamic paraventricular nucleus (PVN), using probes for both ...

journal_title：Endocrinology

authors： Ma XM,Levy A,Lightman SL

更新日期：1997-10-01 00:00:00

abstract：:We previously characterized the transcriptional activity of the human CRH (hCRH) gene promoter in the mouse anterior pituitary cell line AtT20. Here, we show that phorbolester stimulated through the cAMP response element (CRE), located between -227 and -220 relative to the putative cap site, about 2.6-fold the express...

journal_title：Endocrinology

authors： Van LP

更新日期：1993-01-01 00:00:00

abstract：:Rabbit uterine muscle may contract or relax with adrenergic stimulation depending on the hormonal milieu. This difference in contractile activity has been shown to be due to alteration of adrenergic response between alpha-adrenergic (contraction) and beta-adrenergic (relaxation). When rabbits are treated with estrogen...

journal_title：Endocrinology

authors： Roberts JM,Insel PA,Goldfien RD,Goldfien A

更新日期：1977-12-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms whereby ovarian hormones, and particularly estrogens, modulate fat cell metabolism, we investigated the effects of estradiol administration on c-fos and c-jun expressions in fat cells from ovariectomized (OVX) rats. Estradiol treatment resulted in a rapid increase in c-fo...

journal_title：Endocrinology

authors： Garcia E,Lacasa D,Giudicelli Y

更新日期：2000-08-01 00:00:00

abstract：:Mouse β-cell-specific reporter lines have played a key role in diabetes research. Although the rat provides several advantages, its use has lagged behind the mouse due to the relative paucity of genetic models. In this report we describe the generation and characterization of transgenic rats expressing a Renilla lucif...

journal_title：Endocrinology

authors： Ghislain J,Fontés G,Tremblay C,Kebede MA,Poitout V

更新日期：2016-03-01 00:00:00

abstract：:Maternal obesity at conception increases the risk of offspring obesity, thus propagating an intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to high fat-diets, gaining greater body weight, fat mass, and additional metabolic sequelae compared to lean controls. In this report, we id...

journal_title：Endocrinology

authors： Shankar K,Zhong Y,Kang P,Lau F,Blackburn ML,Chen JR,Borengasser SJ,Ronis MJ,Badger TM

更新日期：2011-11-01 00:00:00

abstract：:The rapid and temporary suppression of reproductive behavior is often assumed to be an important feature of the adaptive acute stress response. However, how this suppression operates at the mechanistic level is poorly understood. The enzyme aromatase converts testosterone to estradiol in the brain to activate reproduc...

journal_title：Endocrinology

authors： Dickens MJ,Cornil CA,Balthazart J

更新日期：2011-11-01 00:00:00

abstract：:This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...

journal_title：Endocrinology

authors： Foster DL,Ebling FJ,Claypool LE,Woodfill CJ

更新日期：1988-09-01 00:00:00

abstract：:Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...

journal_title：Endocrinology

authors： Lecomte MJ,Bertolus C,Ramanantsoa N,Saurini F,Callebert J,Sénamaud-Beaufort C,Ringot M,Bourgeois T,Matrot B,Collet C,Nardelli J,Mallet J,Vodjdani G,Gallego J,Launay JM,Berrard S

更新日期：2018-04-01 00:00:00

abstract：:Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...

journal_title：Endocrinology

authors： Roa J,Vigo E,Castellano JM,Navarro VM,Fernández-Fernández R,Casanueva FF,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-06-01 00:00:00

abstract：:Regularly menstruating female rhesus monkeys were implanted sc with Silastic tubing packed with estrone. The implants were replaced every 6-8 months to maintain the serum estrone and estradiol concentrations constantly elevated 1.5-2.5-fold, i.e. in the midfollicular phase range, for 4 yr. Increasing the estrone and e...

journal_title：Endocrinology

authors： Billiar RB,Richardson DW,Little B

更新日期：1989-05-01 00:00:00

abstract：:The effects of alloxan-induced diabetes on uterine decidualization and the associated changes in uterine blood flow (UBF) and corpus luteum activity were evaluated in rats between days 4-9 of pseudopregnancy (day 0 = ovulation). Rats were made diabetic (D) with a 40 mg/kg injection (iv) of alloxan on day 1 of pseudopr...

journal_title：Endocrinology

authors： Garris DR

更新日期：1988-02-01 00:00:00