Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey.

Abstract:

:The association of 11 polychlorinated biphenyls (PCBs) with hypertension was investigated using the National Health and Nutrition Examination Survey (NHANES), 1999-2002. The unweighted number of participants assessed for hypertension ranged from 2074 to 2556 depending on the chemical(s) being analyzed. In unadjusted logistic regressions all 11 PCBs were associated with hypertension. After adjustment for age, gender, race, smoking status, body mass index, exercise, total cholesterol, and family history of coronary heart disease, seven of the 11 PCBs (PCBs 126, 74, 118, 99, 138/158, 170, and 187) were significantly associated with hypertension. The strongest adjusted associations with hypertension were found for dioxin-like PCBs 126 and 118. PCB 126>59.1 pg/g lipid adjusted had an odds ratio of 2.45 (95% CI 1.48-4.04) compared to PCB 12627.5 ng/g lipid adjusted had an odds ratio of 2.30 (95% CI 1.29-4.08) compared to PCB 118or=20 years old in the non-institutionalized US population. We hypothesize that association of seven PCBs with hypertension indicates elevated PCBs are a risk factor for hypertension. What clinicians can do, given the results of this study, is limited unless the appropriate laboratory methods can be made more widely available for testing patients.

journal_name

Environ Res

journal_title

Environmental research

authors

Everett CJ,Mainous AG 3rd,Frithsen IL,Player MS,Matheson EM

doi

10.1016/j.envres.2008.05.006

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

94-7

issue

1

eissn

0013-9351

issn

1096-0953

pii

S0013-9351(08)00129-1

journal_volume

108

pub_type

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