Abstract:
BACKGROUND:Generalized anxiety disorder (GAD) is a chronic disorder associated with significant morbidity and disability. Traditional therapies are associated with poor levels of remission, and often result in troublesome side effects. METHODS:This was a 12-week, open-label, flexible-dose study to assess the efficacy and tolerability of quetiapine as an adjunctive treatment to traditional medication. 40 outpatients with GAD who had not achieved remission following at least 8 weeks of an adequate dose of traditional therapy were enrolled. The primary endpoint was the mean change from pre-treatment to week 12 in the Hamilton Anxiety Rating Scale (HAM-A) total scores. Secondary endpoints included: the proportion of patients achieving remission (HAM-A total score of < or =10 at week 12), Clinical Global Impressions-Severity of Illness (CGI-S), Clinical Global Impressions-Global Improvement (CGI-I), Pittsburgh Sleep Quality Index (PSQI) and Penn State Worry Questionnaire (PSWQ). RESULTS:Adjunctive quetiapine (mean dose 386mg/day at week 12) significantly reduced the HAM-A total scores from pre-treatment (29.8+/-9.0) to week 12 (9.0+/-10.2) (-20.6; p<0.001). The HAM-A remission rate was 72.1% at week 12. Adjunctive quetiapine resulted in a significant reduction in all efficacy measures by study end. Quetiapine was well tolerated: the most common adverse event (AE) was sedation, with no incidence of serious AEs and no clinically significant changes in vital signs, weight (mean gain 0.5kg at week 12) or laboratory assessments. CONCLUSION:The results of this small pilot trial suggest that quetiapine adjunctive to traditional therapy may be a useful treatment in patients with GAD or treatment-resistant GAD, and warrant further investigation.
journal_name
J Anxiety Disordjournal_title
Journal of anxiety disordersauthors
Katzman MA,Vermani M,Jacobs L,Marcus M,Kong B,Lessard S,Galarraga W,Struzik L,Gendron Adoi
10.1016/j.janxdis.2008.03.002subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1480-6issue
8eissn
0887-6185issn
1873-7897pii
S0887-6185(08)00063-7journal_volume
22pub_type
杂志文章abstract::Social anxiety disorder and body dysmorphic disorder are considered nosologically distinct disorders. In contrast, some cognitive models suggest that social anxiety disorder and body dysmorphic disorder share similar cognitive maintenance factors. The aim of this study was to examine the effects of psychological treat...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.janxdis.2013.07.005
更新日期:2013-10-01 00:00:00
abstract::Childhood adversities are key aetiological factors in the onset and persistence of psychopathology. The aims of this study were to identify childhood adversity profiles, and investigate the relationship between the adversity classes and psychopathology in Northern Ireland. The study utilized data from the Northern Ire...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2015.07.004
更新日期:2015-10-01 00:00:00
abstract::Learning and memory are interdependent processes. Memories are learned, and cumulative learning requires memory. It is generally accepted that learning contributes to psychopathology and consequently to pertinent memory formation. Neuroscience and psychological research have established that memory is an active recons...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章,评审
doi:10.1016/j.janxdis.2008.11.003
更新日期:2009-05-01 00:00:00
abstract::Evidence suggests that anxiety sensitivity (AS) contributes to individual differences in fearfulness and to the risk of developing anxiety disorders. To investigate the origins of AS we administered the Anxiety Sensitivity Index to 245 monozygotic and 193 dizygotic twin pairs, comprising 658 women and 218 men. Scores ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2007.09.005
更新日期:2008-06-01 00:00:00
abstract::Recent cognitive models stress the impact that negative appraisals have on the maintenance of posttraumatic stress disorder (PTSD). The aim of this study was to investigate the role of posttraumatic negative cognitions in 110 survivors of motor vehicle accidents (MVAs) and to examine the effect of cognitive-behavioral...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.janxdis.2009.03.001
更新日期:2009-08-01 00:00:00
abstract::An attentional bias for trauma-related stimuli has been demonstrated in individuals with posttraumatic stress disorder (PTSD). However, few studies have investigated how biological relatives of individuals with PTSD process trauma-relevant information. To investigate whether parental PTSD is associated with an attenti...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2010.06.023
更新日期:2010-12-01 00:00:00
abstract::The GAD-7 is a popular measure of generalized anxiety disorder (GAD) symptoms that has been used across many cultural groups. Existing evidence demonstrates that the prevalence of GAD varies across self-identified ethnic/cultural groups, a phenomenon that some researchers attribute to cross-cultural measurement error ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2015.01.005
更新日期:2015-04-01 00:00:00
abstract::The aim of the study was to explore differential attention profiles, according to attention types, in sub-clinical obsessive-compulsive checkers compared to controls. To examine attention biases in obsessive-compulsive phenomena, we compared sub-clinical checkers to non-checkers on their recall and recognition perform...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2009.01.007
更新日期:2009-04-01 00:00:00
abstract::Dizziness can be associated with otologic, neurologic, medical, and psychiatric conditions. This paper focuses on the interface between otologic and psychiatric conditions. Because dizziness often is situation specific, concepts of space and motion sensitivity (SMS), space and motion discomfort (SMD), and space and mo...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章,评审
doi:10.1016/s0887-6185(00)00040-2
更新日期:2001-01-01 00:00:00
abstract::Although results regarding objective social skills deficits in adults are inconsistent, research with youth have consistently demonstrated such deficits. Furthermore, research has consistently demonstrated subjective appraisal of social skill deficit in both youth and adults with social phobia or social anxiety. As a ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2006.03.013
更新日期:2007-01-01 00:00:00
abstract::Peer dislike of anxious behaviour was investigated in 7-12 year olds. Child actors delivered an identical verbal presentation: once in an anxious manner and once confidently. The videos were rated for liking and seven potential mediators by three groups of children: 32 anxiety-disordered peers with social phobia; 16 a...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2014.06.007
更新日期:2014-08-01 00:00:00
abstract::Social anxiety disorder is associated with interpersonal dysfunction, but it is not clear why people with the disorder feel unsatisfied with their relationships. One possibility is that higher social anxiety could lead to changes in sensitivity to interpersonal traits. We examined whether social anxiety moderates the ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2016.01.002
更新日期:2016-03-01 00:00:00
abstract::Contemporary cognitive models of obsessive-compulsive disorder (OCD) emphasize the importance of various types of dysfunctional beliefs in contributing to OC symptoms, such as beliefs about excessive personal responsibility, perfectionism, and intolerance for uncertainty. The present study seeks to further our underst...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2014.03.004
更新日期:2014-05-01 00:00:00
abstract::The purpose of this study was to determine the validity of the State-Trait Anxiety Inventory (STAI) in predicting DSM-III-R anxiety disorders based on the Diagnostic Interview Schedule for Children (DISC, Version 2.3) and using Asian/Pacific Islander adolescents. An overall prevalence rate of 9.19% for generalized anx...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/s0887-6185(01)00079-2
更新日期:2001-11-01 00:00:00
abstract::Not Just Right Experiences (NJREs) are considered to be a perceptually tinged phenomenon mainly related to obsessive-compulsive disorder (OCD). The evidence of an association between NJREs and OCD or OC symptoms have been accumulating in the last few years, whereas there is a paucity of studies about the role of this ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2015.02.002
更新日期:2015-04-01 00:00:00
abstract::The prevalence and expression of post-traumatic stress disorder (PTSD) symptoms among United States Air Force remotely piloted aircraft (RPA; commonly referred to as "drones") warfighters exposed to battlefield trauma via remote, electronic warfare is relevant and critical to the effective delivery of mental health ca...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2019.01.003
更新日期:2019-03-01 00:00:00
abstract::A considerable body of research has identified various child and parent factors that contribute to and maintain anxiety symptoms in children. Yet relatively few studies have examined child factors (including threat-based cognitive bias, neuroticism, gender, puberty and age) as well as parent factors (including materna...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2012.06.002
更新日期:2012-10-01 00:00:00
abstract::We evaluated whether traumatic events are associated with a distinctive pattern of socio-demographic and clinical features of obsessive-compulsive disorder (OCD). We compared socio-demographic and clinical features of 106 patients developing OCD after post-traumatic stress disorder (PTSD; termed post-traumatic OCD), 4...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2011.12.001
更新日期:2012-03-01 00:00:00
abstract::This study evaluated the psychometric properties of the Social Phobia Scale and Social Interaction Anxiety scale in a community sample of African Americans. We conducted a confirmatory factor analysis of the combined scales comparing the data to 2- and 3-factor solutions commonly reported in the literature. The result...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2014.07.003
更新日期:2014-10-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic sparked significant anxiety regarding viral rates and means of transmission. Heightened concerns about contamination have prompted new hygienic strategies to vigilantly guard against infection, including hand washing immediately after touching foreign objects or suspect...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2020.102270
更新日期:2020-08-01 00:00:00
abstract::Previous research has consistently demonstrated that Prolonged Exposure (PE) therapy is an effective treatment for posttraumatic stress disorder (PTSD). Traditionally, PE has been studied and delivered on an individual basis. However, the growing number of Veterans in need of PTSD treatment has led to increased intere...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2014.12.008
更新日期:2015-03-01 00:00:00
abstract::Previous research has shown racial/ethnic differences in Vietnam veterans on symptoms related to posttraumatic stress disorder (PTSD). The current study explored racial/ethnic differences in PTSD symptoms and clinically relevant symptoms. Resilience and social support were tested as potential moderators of racial/ethn...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2016.09.004
更新日期:2016-10-01 00:00:00
abstract::The COVID-19 public health crisis has led to extensive recommendations by officials to contain its spread. Anxiety regarding contracting the virus is prominent in the public. Specific routes to anxiety over disease contraction are under studied. It is expected that a contributory feature of fear of contracting COVID-1...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2020.102233
更新日期:2020-06-01 00:00:00
abstract::This study examined the influence of a mass trauma (the Virginia Tech campus shootings) on anxiety symptoms and quality of life, as well as the potential vulnerability/protective roles of world assumptions and social support. Pre-trauma adjustment data, collected in the six months prior to the shooting, was examined a...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2010.12.003
更新日期:2011-05-01 00:00:00
abstract::Few studies have examined why socially related fears and posttraumatic stress commonly, but not invariably, co-occur. It may be that only traumata of human agency (e.g., sexual assault), for which there is an interpersonal component, give rise to co-occurring socially related fears. These symptoms might also co-occur ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2008.07.006
更新日期:2009-03-01 00:00:00
abstract::Alcohol dependence (AD) is more likely to occur among individuals with rather than without an anxiety disorder. Self-medication theory (SMT) holds that drinking behavior is negatively reinforced when alcohol temporarily reduces anxiety and that the resulting escalation of drinking increases the risk for AD. We set out...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2010.10.006
更新日期:2011-04-01 00:00:00
abstract::Although research has implicated disgust in the fainting response observed in blood-injection-injury (BII) phobia, this finding has not been consistently observed in the literature. The present study further examines the relationship between disgust and fainting symptoms among injection-fearful (n=108) and nonfearful ...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2010.06.021
更新日期:2010-12-01 00:00:00
abstract::Clinical effectiveness of group cognitive-behavioral therapy (GCBT) versus fluoxetine in obsessive-compulsive disorder outpatients that could present additional psychiatric comorbidities was assessed. Patients (18-65 years; baseline Yale-Brown Obsessive-Compulsive-Scale [Y-BOCS] scores ≥ 16; potentially presenting add...
journal_title:Journal of anxiety disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.janxdis.2011.08.008
更新日期:2012-01-01 00:00:00
abstract::This study examines how cognitive variables, which play a central role in the development and maintenance of generalized anxiety disorder (GAD), manifest themselves when GAD and major depressive disorder (MDD) are comorbid. Thirty-two participants were divided into two groups, a group of individuals with a principal d...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2007.05.010
更新日期:2008-01-01 00:00:00
abstract::This study investigated the role of both negative and positive cognitions in predicting panic severity in an international sample of patients diagnosed with panic disorder (with and without agoraphobia). One hundred and fifty-nine patients were administered the Brief Bodily Sensations Interpretation Questionnaire (BBS...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/S0887-6185(02)00257-8
更新日期:2004-01-01 00:00:00