Abstract:
:Fluconazole is recommended in the prophylaxis of oropharyngeal candidiasis (OPC) in patients undergoing radiotherapy for head-neck tumours; however, the actual effectiveness of fluconazole in this setting remains unclear. Adult patients with cervico-cephalic carcinoma submitted to radical or adjuvant radiotherapy were randomized to 100 mg fluconazole (n = 138) or matched placebo (n = 132) oral suspension once daily from the sixth session of radiotherapy up to the end of treatment. The final analysis of the investigation showed a higher rate of the OPC outbreak-free survival in the fluconazole compared with placebo (P = 0.008 in the log-rank test). The mean time (95% CI) to OPC outbreak was 56 (53-59) days in the fluconazole group and 47 (43-51) days with placebo. The mean duration of radiotherapy was 43.5 and 39.9 days, respectively in the two groups (P = 0.027). Adverse effects were reported in 70.3% of patients in the fluconazole group and in 67.4% with placebo. The results showed prophylaxis with fluconazole given in irradiated patients with head-neck tumours significantly reduces the rate and the time to development of OPC compared with placebo.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Corvò R,Amichetti M,Ascarelli A,Arcangeli G,Buffoli A,Cellini N,Cionini L,De Renzis C,Emiliani E,Franchini P,Gabriele P,Gobitti C,Grillo Ruggieri F,Bertoni F,Magrini SM,Marmiroli L,Orsatti M,Panizza GM,Tordiglione M,doi
10.1111/j.1365-2354.2007.00855.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
270-7issue
3eissn
0961-5423issn
1365-2354pii
ECC855journal_volume
17pub_type
杂志文章,随机对照试验abstract::Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects. Ondansetron and later members of the 'setron class are currently standard treatments for cancer chemotherapy-related nausea and emesis. They are potent 5-HT3 blockers, but it is often not appreciated that mirtazapine and olanz...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00760.x
更新日期:2007-07-01 00:00:00
abstract::Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and mortality. It is the result of an increased activity of osteoclasts, which is not followed by reactive bone formation by osteoblasts. Recent studies have revealed no...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12761
更新日期:2017-11-01 00:00:00
abstract::With fever being the most common manifestation of early sepsis, clinical practice guidelines emphasise the prompt institution of broad-spectrum antibacterial therapy at its onset. An audit was performed on the haematology ward to determine whether there was any delay in starting antibiotic treatment during neutropenia...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2011.01264.x
更新日期:2011-09-01 00:00:00
abstract::The study aimed to evaluate cancer-targeting potential of a newly synthesised radiopharmaceutical, 99m Tc-resveratrol in vivo, using colon cancer model. Colon cancer was induced in 20 male Sprague-Dawley rats by subcutaneous administration of 1,2-dimethylhydrazine (DMH), dissolved in 1 mM EDTA-normal saline, at a dose...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12504
更新日期:2017-09-01 00:00:00
abstract::Somatic mutations in key oncogenes in non-small cell lung cancer (NSCLC) and melanoma are important determinants of tumour sensitivity to targeted therapies. Molecular screening for these predictive biomarkers is routinely used to inform treatment decisions; however, little is known about how best to communicate testi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12600
更新日期:2017-11-01 00:00:00
abstract::Informational need assessment has become an important part of health care in order to provide information effectively in clinical settings. Literature on information needs in the West suggests that breast cancer (BC) patients needed more information than doctors had provided, and information that fully met their needs...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2008.00936.x
更新日期:2009-03-01 00:00:00
abstract::Delays in the diagnosis of cancer are common, and they are attributed to both patient and healthcare system factors. Minimizing such delays and improving early detection rates is a key goal of the new cancer reform strategy in England, in light of recent data showing that survival rates in the UK are low. The aim of t...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2354.2008.01020.x
更新日期:2010-01-01 00:00:00
abstract::A project was funded by the UK's Department of Health to develop national guidelines for breast cancer related lymphoedema using a Consensus Strategy. This involved the organization of a consensus conference with a multidisciplinary panel of experts, an extensive literature review, the production of clinical guideline...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1996.tb00243.x
更新日期:1996-12-01 00:00:00
abstract::As part of a major study of the impact of childhood cancer on Chinese families, 17 families agreed to be interviewed after the death of their child from cancer. They convey what happens to the child's body after death and what remembrances the family has kept of their child's belongings. They share how they have adjus...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1993.tb00192.x
更新日期:1993-12-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12809
更新日期:2018-03-01 00:00:00
abstract::This paper describes the practice of palliative nursing care in Spain. The management of palliative hospital and home care is presented. Nursing roles in the multidimentional aspects (physical, psychological, social, cultural and spiritual) of patient and family care are provided. Nursing participation in informing an...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2001.00289.x
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:The goal of our study was to evaluate the reliability, validity, responsiveness and acceptability of the Mandarin (simplified) Chinese version of the EORTC QLQ-OH45. METHODS:From October 2017 to February 2018, 393 cancer patients were enrolled from three different hospitals in China. A forward and backward tra...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.12987
更新日期:2019-03-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2003.00381.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE/BACKGROUND:Discussion of treatment goals between oncologists and patients is challenging. Patients frequently misunderstand goals of therapy. There are several methods to document goals of chemotherapy, however, and are frequently not incorporated into patient charts. METHODS/DESIGN:Cancer patients receiving...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12973
更新日期:2019-03-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1997.00018.x
更新日期:1997-06-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2004.00458.x
更新日期:2004-03-01 00:00:00
abstract::In South Africa, cervical cancer is the most common female cancer followed by breast cancer. Despite the high incidence of these cancers, population-based screening is limited to cervical screening available at primary health clinics. Cervical screening uptake is, however, low. In 2009 a new cancer prevention initiati...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12005
更新日期:2013-01-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12910
更新日期:2018-11-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1997.00024.x
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journal_title:European journal of cancer care
pub_type: 杂志文章
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journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2354.2009.01149.x
更新日期:2011-01-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12991
更新日期:2019-03-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2354.2003.00418.x
更新日期:2003-12-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12566
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Mastectomy patients' satisfaction with reconstructive options has not been examined. METHODS:A national study measured 18-month satisfaction with reconstructive options and collected case-mix and reconstructive offer and uptake data on breast cancer patients having mastectomy with or without immediate rec...
journal_title:European journal of cancer care
pub_type: 杂志文章
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更新日期:2020-11-10 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1998.00107.x
更新日期:1998-12-01 00:00:00
abstract::Threatening nature of childhood cancer and the aggressiveness of prescribed treatments place enormous stress on the family of children suffering from cancer. This study was conducted to better understand the lived experiences of parents of children suffering from cancer and to document their account of such experience...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2011.01307.x
更新日期:2012-05-01 00:00:00