Abstract:
:Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and mortality. It is the result of an increased activity of osteoclasts, which is not followed by reactive bone formation by osteoblasts. Recent studies have revealed novel molecules and pathways that are implicated in osteoclast activation and osteoblast inhibition. Among them, the most important include the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin pathway, the macrophage inflammatory proteins and the activin-A that play a crucial role in osteoclast stimulation in myeloma, while the wingless-type (Wnt) signalling inhibitors (sclerostin and dickkopf-1) along with the growth factor independence-1 are considered the most important factors for the osteoblast dysfunction of myeloma patients. Finally, the role of osteocytes, which is the key cell for normal bone remodelling, has also revealed during the last years through their interaction with myeloma cells that leads to their apoptosis and the release of RANKL and sclerostin maintaining bone loss in these patients. This review focuses on the latest available data for the mechanisms of bone destruction in multiple myeloma.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Terpos E,Christoulas D,Gavriatopoulou M,Dimopoulos MAdoi
10.1111/ecc.12761subject
Has Abstractpub_date
2017-11-01 00:00:00issue
6eissn
0961-5423issn
1365-2354journal_volume
26pub_type
杂志文章,评审abstract::Although data from literature suggest that diabetic women are frequently under screened for gynaecological cancers little is known about screening implementation for other cancers for both genders. This study investigates comprehensive cancer screening practices of diabetics as compared with non-diabetics; analyses sc...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2007.00858.x
更新日期:2009-05-01 00:00:00
abstract::Discharge from hospital follow-up is a key time point in the cancer journey. With recommendations for earlier discharge of cancer survivors, attention to the discharge process is likely to become increasingly important. This study explored cancer survivors' experiences of discharge from hospital follow-up. Survivors o...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2011.01312.x
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abstract::The purpose of this study is to document infection and to better understand current practice relating to antibiotic use and its effect in terminal cancer patients. We retrospectively reviewed patients with terminal stage cancer who were admitted to Seoul National University Boramae Hospital for symptom control only, a...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2005.00603.x
更新日期:2006-03-01 00:00:00
abstract::To investigate health professionals' perspectives about factors that impede or facilitate cancer care for Indigenous people. Semi-structured interviews with 22 health professionals involved in Indigenous cancer care. Data were interpreted using an inductive thematic analysis approach. Participants presented their pers...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12467
更新日期:2016-03-01 00:00:00
abstract::This study examines the prevalence of suspected cervical cancer (established through the use of visual inspection with Lugol's Iodine - VILI) among outpatients attending Surat Municipal Institute of Medical Education & Research Hospital, India. A cross-sectional study was conducted on 356 patients; 178 with an establi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12626
更新日期:2017-01-01 00:00:00
abstract::The aim of this study is to review the practice and outcomes at our institution of percutaneous transhepatic placement of metallic biliary stents for non-hepato-biliary/pancreatic (non-HBP) malignant obstructive jaundice. A retrospective review was performed of the records of all patients undergoing transhepatic stent...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2009.01120.x
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abstract::Based on promising preclinical data, a progressive series of evaluations of the use of high-dose mitoxantrone-based chemotherapy was initiated in acute leukaemia patients. A preliminary phase I study demonstrated that up to 80 mg/m2 of mitoxantrone in combination with cytarabine 3 g/m2 daily for 5 days could be given ...
journal_title:European journal of cancer care
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1111/j.1365-2354.1997.tb00322.x
更新日期:1997-12-01 00:00:00
abstract::Cancer is difficult for people from ethnically diverse communities to cope with, because there is inequality in getting information and services to meet their needs for prevention, prompt diagnosis, treatment, care and support. Research with black minority ethnic (BME) communities indicates a lack of knowledge about c...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00719.x
更新日期:2007-03-01 00:00:00
abstract::This systematic review and meta-analysis aimed to evaluate the effectiveness of psychological interventions in improving quality of life for head and neck cancer patients. Five databases were systematically searched in July 2016. Studies were included if they reported original empirical data from intervention studies ...
journal_title:European journal of cancer care
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ecc.12789
更新日期:2018-01-01 00:00:00
abstract::There has been a recent increase in research considering the perceptions of the term "cancer survivor" held by individuals who have or have had cancer. This article explores the meaning of the term to young women living with a history of breast cancer. Twenty women participated in semi-structured interviews about thei...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12847
更新日期:2018-05-01 00:00:00
abstract::Drug interactions are commonly seen in the treatment of cancer patients. Psychotropics are often indicated for these patients since they may also suffer from pre-existing psychological disorders or experience insomnia and anxiety associated with cancer therapy. Thus, the risk of anticancer drug (ACD)-psychotropic drug...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2009.01113.x
更新日期:2011-01-01 00:00:00
abstract::Surgical cytoreduction and platinum/taxane combination chemotherapy are the mainstay for the treatment of epithelial ovarian cancer patients. In order to minimise the tumour mass before chemotherapy, cytoreductive surgery is usually performed first. Currently, a splenectomy is included as part of surgical cytoreductio...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2010.01224.x
更新日期:2011-05-01 00:00:00
abstract::This study aimed at developing and measuring quality indicators for oesophageal cancer (OC) and gastric cancer (GC) and to support quality improvement for practitioners. Quality indicators were identified from a systematic literature search including clinical guidelines. The selection process involved experts evaluati...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12279
更新日期:2015-05-01 00:00:00
abstract::This study aimed to identify high support needs and their socio-demographic predictors to improve supportive care for newly diagnosed breast cancer patients. A cross-sectional study measured patients' needs and unsatisfied support needs by the supportive care needs survey (SCNS-34), administered after surgery, chemoth...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2010.01190.x
更新日期:2011-07-01 00:00:00
abstract::The aims were to investigate whether: (A) doctors' ability to identify patients' worry about prognosis/wish for information about disease and treatment is related to doctors' self-efficacy with regard to communicating about difficult matters and patients' satisfaction with a consultation/hope to live a good life in sp...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00670.x
更新日期:2006-09-01 00:00:00
abstract::This paper examines the relationship between medical professionals and parents of young adults who are being treated by them for cancer. This study aims to discover what practices and procedures make the cancer journey easier or more difficult to manage for parents in the medical setting. Many studies of carers focus ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2004.00458.x
更新日期:2004-03-01 00:00:00
abstract::We studied a series of 93 patients diagnosed with craniopharyngioma during a 15-year period with respect to presenting symptom, clinical course and management. The majority (62%) of patients were men, and had presented with neurological symptoms (75%), with headaches (82%) being the most common presenting symptom. The...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2003.00433.x
更新日期:2004-03-01 00:00:00
abstract::As part of a major study of the impact of childhood cancer on Chinese families, 17 families agreed to be interviewed after the death of their child from cancer. They convey what happens to the child's body after death and what remembrances the family has kept of their child's belongings. They share how they have adjus...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1993.tb00192.x
更新日期:1993-12-01 00:00:00
abstract::Surgery is the treatment of choice in most head and neck cancers. Very often, the surgery is radical with high impact on the psychosocial, functional and aesthetic fields. The aim of this study is to gain a deeper understanding of the patient's, clinician's and key informant's point of view when surgery is proposed, t...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.13062
更新日期:2019-07-01 00:00:00
abstract::Although psychological resilience has been shown to 'buffer' against depression following major stressors, no studies have reported on this relationship within the prostate cancer (PCa) population, many of whom are at elevated risk of depression, health problems and suicide. To investigate the effects of resilience up...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.12170
更新日期:2014-07-01 00:00:00
abstract::Although several studies have reported the impact of oesophagectomy on health-related quality of life (HRQOL), none has objectively assessed its impact on physical fitness. This study aimed to evaluate the impact of oesophagectomy on physical fitness and HRQOL in patients with oesophageal cancer. In this prospective s...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12030
更新日期:2013-05-01 00:00:00
abstract::Informational need assessment has become an important part of health care in order to provide information effectively in clinical settings. Literature on information needs in the West suggests that breast cancer (BC) patients needed more information than doctors had provided, and information that fully met their needs...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2008.00936.x
更新日期:2009-03-01 00:00:00
abstract::Patients with various forms of cancer receiving blood and marrow transplant (BMT) treatment at an outpatient clinic develop chemotherapy-related symptoms and an increased desire to use complementary and alternative medicine in order to address these symptoms. Art-making offers an inexpensive way to pass time and relie...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12482
更新日期:2017-09-01 00:00:00
abstract::Supported self-care interventions are a low-intensity treatment for depression that has received little research attention in the cancer population. This is a phase II intervention only study to test the feasibility, acceptability and preliminary effectiveness of a depression self-care intervention for cancer patients...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12763
更新日期:2018-01-01 00:00:00
abstract::Constipation and the laxatives polyethylene glycol (PEG), sodium picosulphate (SPS) and lactulose (L) were investigated in outpatients with cancer and on opioid therapy. Randomly selected patients were enrolled in a prospective, controlled, open-label trial. Endpoints were number of patients taking laxatives >28 days,...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2354.2011.01286.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Breast cancer treatments not only affect body image but also other aspects of women's lives. Women try to accept their appearance through coping strategies. This study aimed to determine the relationship between body image and coping strategies in women with breast cancer following surgery in southeast Iran. ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13191
更新日期:2020-01-01 00:00:00
abstract::This paper compares quality of life in breast and rectal cancer patients. The Munich Cancer Registry records clinical details of all cancer patients in the region. Over a 2-year period, cooperating clinicians recruited patients who were sent quality of life questionnaires, including the European Organization for Resea...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2003.00414.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Fear of cancer recurrence (FCR) is the most commonly reported problem and unmet need among breast cancer survivors. The aim of this qualitative study was to explore the experience of recurrence fears among Taiwanese breast cancer survivors. METHODS:Three focus groups were included in this study. A purposive ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13113
更新日期:2019-09-01 00:00:00
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journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2006.00686.x
更新日期:2006-12-01 00:00:00
abstract::Research indicates there is confusion in the minds of patients and the public surrounding the issue of 'informed consent'. This confusion is compounded when patients are asked to participate in a clinical trial. This study aimed to survey, by self-completed postal questionnaires, the experiences and opinions of 100 ra...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1994.tb00037.x
更新日期:1994-12-01 00:00:00