Abstract:
:Based on promising preclinical data, a progressive series of evaluations of the use of high-dose mitoxantrone-based chemotherapy was initiated in acute leukaemia patients. A preliminary phase I study demonstrated that up to 80 mg/m2 of mitoxantrone in combination with cytarabine 3 g/m2 daily for 5 days could be given as induction therapy to leukaemic patients with acceptable toxicity. Pharmacokinetic data from these patients demonstrated that high concentrations of mitoxantrone were achievable in vivo to levels that were extremely cytotoxic in vitro. Subsequently, in a phase II study, 45 patients with untreated acute myelogenous leukaemia (AML) under the age of 60 received mitoxantrone 80 mg/m2 in combination with cytarabine 3 g/m2 daily for 5 days and etoposide 150 mg/m2 for 3 days. Following this induction, patients received five cycles of consolidation with cytarabine 3 g/m2 daily for 4 days with mitoxantrone 20 mg/m2 for 1 day on cycles 2 and 4, and etoposide 150 mg/m2 for 2 days with cytarabine on courses 1, 3 and 5. The patients in this study achieved a complete remission (CR) rate of 80% and a 3-year projected probability of survival of 40%. In a second AML study, 54 adults over the age of 60 with untreated AML were randomized to receive either high-dose or standard-dose mitoxantrone with cytarabine as a single induction regimen without consolidation. Patients receiving high-dose mitoxantrone did not experience increased morbidity or mortality compared with those given lower doses. Comparison of CR rates, disease-free and overall survival consistently favoured high-dose mitoxantrone, although the results did not achieve statistical significance. In patients with acute lymphocytic leukaemia (ALL), high-dose mitoxantrone with cytarabine was given as initial therapy in a phase II study involving 37 previously untreated adults. Results demonstrated that this dose-intensive regimen could produce a high CR rate (84%) with acceptable toxicity and compared favourably with experiences with vincristine/prednisone-based induction regimens. These studies demonstrate that high-dose mitoxantrone can be safely and effectively administered to patients with acute leukaemia and suggest that the incorporation of high doses of mitoxantrone into treatment regimens may lead to enhanced antileukaemic efficacy compared with standard doses. Phase III evaluations are planned.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Feldman EJdoi
10.1111/j.1365-2354.1997.tb00322.xsubject
Has Abstractpub_date
1997-12-01 00:00:00pages
27-32issue
4 Suppleissn
0961-5423issn
1365-2354journal_volume
6pub_type
临床试验,杂志文章,随机对照试验,评审abstract::This article discusses in-depth interviews of 12 persons, who had been diagnosed for cancer from 6 months to 3 years earlier, concerning what it is like to live with the diagnosis of cancer. The persons interviewed were aged 43-70 years, and 11 of the 12 had received successful radical treatment; one patient was treat...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2004.00442.x
更新日期:2004-05-01 00:00:00
abstract::Berlin-Frankfurt-Munster (BFM) and Dana-Farber Cancer Institute (DFCI) consortia's treatment strategies for acute lymphoblastic leukaemia (ALL) in children are widely used. We compared the health effects and monetary costs of hospital treatments for these two strategies. Parents of children treated at seven centres in...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12173
更新日期:2014-11-01 00:00:00
abstract::A retrospective analysis of first-time enquirers using a cancer information service in Belfast, Northern Ireland, is presented. Our results show that women are three times more likely to use the service than men, with relatives and friends more likely to seek information on behalf of cancer patients than patients them...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2002.00299.x
更新日期:2002-06-01 00:00:00
abstract::To examine the incidence, characteristics, therapeutic approach and survival of diagnosed lung cancer (LC) in the Santiago de Compostela Health Area. A retrospective study was carried out on LC for a period of 3 years. Of the 481 cases collected, 92.7% were male. The median age was 66.93 years. The crude incidence for...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2354.2008.01008.x
更新日期:2010-03-01 00:00:00
abstract::Psychosocial transitions were assessed in the long-term survivors of bone marrow transplantation (BMT). A combination of quantitative and qualitative data from 91 survivors led to the identification of several psychosocial phases and transit points after the transplant. Throughout the years post-BMT survivors were con...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1997.00018.x
更新日期:1997-06-01 00:00:00
abstract::As part of a major study of the impact of childhood cancer on Chinese families, 17 families agreed to be interviewed after the death of their child from cancer. They convey what happens to the child's body after death and what remembrances the family has kept of their child's belongings. They share how they have adjus...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1993.tb00192.x
更新日期:1993-12-01 00:00:00
abstract::This paper compares quality of life in breast and rectal cancer patients. The Munich Cancer Registry records clinical details of all cancer patients in the region. Over a 2-year period, cooperating clinicians recruited patients who were sent quality of life questionnaires, including the European Organization for Resea...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2003.00414.x
更新日期:2003-09-01 00:00:00
abstract::In this study, we compared cancer patients preference for computerised (tablet/web-based) surveys versus paper. We also assessed whether the understanding of a cancer-related topic, pharmacogenomics is affected by the survey format, and examined differences in demographic and medical characteristics which may affect p...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12318
更新日期:2016-03-01 00:00:00
abstract::This study aims to describe the experiences of nurses caring for cancer patients in non-specialist wards. The study was conducted in a large (420 beds) and small (32 beds) hospital in an area health service with urban and rural populations in the west of Sydney. A qualitative descriptive approach was utilized to colle...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2354.2005.00566.x
更新日期:2005-07-01 00:00:00
abstract::Literature has documented personality and coping strategies as valuable intrapersonal resources for cancer adjustment among Caucasians. Nevertheless, it remains unclear whether these personal characteristics operate in a similar manner among cancer patients of different ages and cultural backgrounds. This study examin...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12781
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To examine follow-up procedures after men are discharged into primary care following prostate cancer and highlight any areas for service improvement. METHODS:Patient record data from two Greater Manchester boroughs were retrieved retrospectively to investigate discharge instructions and monitoring adherence....
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13389
更新日期:2020-12-18 00:00:00
abstract::The fear of cancer recurrence is cited as a motivator of women's preferences between routine monitoring and contralateral prophylactic mastectomy (CPM) as methods of managing ongoing breast cancer risk. We conducted a discrete choice experiment among a general community sample of women who completed 12 hypothetical ch...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/ecc.13058
更新日期:2019-07-01 00:00:00
abstract::To identify the views of health professionals working in childhood cancer on seeking consent to tissue banking from potential donors. Self-completion questionnaires sent to 553 UK paediatric oncology health professionals. The response rate was 60%. Respondents (100%) were in favour of using tissue samples from childre...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2008.01033.x
更新日期:2009-07-01 00:00:00
abstract::The aim of this paper was to discuss how words for symptoms relate to experience and to find out how seriously ill patients two years after diagnosis and treatment articulated suffering. Nine patients who have had a cancer tumour of the central nervous system were interviewed in their homes and the findings were inter...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2007.00873.x
更新日期:2008-11-01 00:00:00
abstract::The need for information by the caregiving family of an adult patient with cancer has been identified by research. This paper is a literature review of the information and learning needs of caregiving relatives. By meeting these needs the health care professional is able to help support the family, and therefore the p...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.1995.tb00068.x
更新日期:1995-09-01 00:00:00
abstract::This module discusses the diverse cultural needs of people affected by cancer and how those needs can be assessed and met. The UK experience with Black or Minority Ethnic (BME) communities will be used to explore the issues of awareness of and detection of cancer. ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2008.01078.x
更新日期:2009-01-01 00:00:00
abstract::When two or more persons, e.g. nurses and patients, act together interaction takes place. The expectations of nurses and their definition of the patient's illness status affect their behaviour towards the patient and how they practice nursing. The aim of this study was to examine the interaction between adults with le...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1998.00063.x
更新日期:1998-03-01 00:00:00
abstract::Patients commonly develop shoulder disability and reduction in quality of life (QOL) following neck dissection surgery. There is a lack of studies investigating the impact of preventative rehabilitation to prevent shoulder disability in this population. An exploratory trial was undertaken to investigate this gap in th...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2354.2009.01149.x
更新日期:2011-01-01 00:00:00
abstract::Randomized controlled trials are accepted to be the research design of choice to evaluate the effectiveness of health care interventions and are commonly used to evaluate cancer treatments. There are concerns, however, that levels of recruitment to trials are often much lower than anticipated, particularly in cancer t...
journal_title:European journal of cancer care
pub_type: 杂志文章,meta分析
doi:10.1046/j.1365-2354.2002.00341.x
更新日期:2002-09-01 00:00:00
abstract::Drug interactions are commonly seen in the treatment of cancer patients. Psychotropics are often indicated for these patients since they may also suffer from pre-existing psychological disorders or experience insomnia and anxiety associated with cancer therapy. Thus, the risk of anticancer drug (ACD)-psychotropic drug...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2009.01113.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Surgery for paediatric cancer presents many stresses on patients and families. The authors aimed to understand the long-term impact of childhood cancer surgery on survivors and parents. METHODS:The study recruited participants from 11 Australia/New Zealand hospitals for telephone interviews. The authors used...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13116
更新日期:2019-09-01 00:00:00
abstract::Close monitoring of chemotherapy toxicity can be instrumental in ensuring prompt symptom management and quality care. Our aim was to develop a brief clinical tool to enable daily assessment of chemotherapy toxicity and investigate/establish its content validity, feasibility/applicability, internal consistency and stab...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12890
更新日期:2018-11-01 00:00:00
abstract::This study examines the prevalence of suspected cervical cancer (established through the use of visual inspection with Lugol's Iodine - VILI) among outpatients attending Surat Municipal Institute of Medical Education & Research Hospital, India. A cross-sectional study was conducted on 356 patients; 178 with an establi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12626
更新日期:2017-01-01 00:00:00
abstract::This study aimed at developing and measuring quality indicators for oesophageal cancer (OC) and gastric cancer (GC) and to support quality improvement for practitioners. Quality indicators were identified from a systematic literature search including clinical guidelines. The selection process involved experts evaluati...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12279
更新日期:2015-05-01 00:00:00
abstract::The aim of this study has been to explore the concept of rehabilitation as a team activity in the oncology setting. The researcher has interviewed 15 members of the rehabilitation team in a specialist oncology rehabilitation centre in the United Kingdom and observed the day-to-day activity in the centre. The grounded ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1993.tb00182.x
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:About 14% of cancer patients live with dependent children. Healthcare professionals are well placed to help patients support their children as part of a patient-centred practice. Children tend to appreciate open communication during the course of illness, but patients often find this difficult. However, resea...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12991
更新日期:2019-03-01 00:00:00
abstract::Supported self-care interventions are a low-intensity treatment for depression that has received little research attention in the cancer population. This is a phase II intervention only study to test the feasibility, acceptability and preliminary effectiveness of a depression self-care intervention for cancer patients...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12763
更新日期:2018-01-01 00:00:00
abstract::A moisturising micro-gel spray for prevention of dryness was compared with commercial products and artificial saliva in vitro and in a clinical setting in patients with cancer. Survival of cultured human gingival epithelial cells was evaluated after treatment with each product for 15 min. A dry test was performed for ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2012.01349.x
更新日期:2012-11-01 00:00:00
abstract::This paper describes the practice of palliative nursing care in Spain. The management of palliative hospital and home care is presented. Nursing roles in the multidimentional aspects (physical, psychological, social, cultural and spiritual) of patient and family care are provided. Nursing participation in informing an...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2001.00289.x
更新日期:2001-12-01 00:00:00
abstract::Several studies support the validity and psychometric properties of the DT&PL for measuring psychosocial distress in breast cancer survivors (BCSs). However, next to psychosocial problems, it is equally important to identify distress caused by limitations in physical functioning. Validity of the DT&PL for the identifi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12880
更新日期:2019-01-01 00:00:00