Abstract:
:A moisturising micro-gel spray for prevention of dryness was compared with commercial products and artificial saliva in vitro and in a clinical setting in patients with cancer. Survival of cultured human gingival epithelial cells was evaluated after treatment with each product for 15 min. A dry test was performed for products giving a 50% survival rate, in which cell survival was measured after drying of cells treated with each product. The survival rates of cells treated with the micro-gel spray and artificial saliva were significantly higher than those of control cells. The micro-gel spray was then evaluated for 1 week in patients with symptoms of dry mouth caused by cancer treatment. There was significant improvement of these symptoms at night and on awakening and of subjective symptoms of decreased salivary volume (P < 0.05). Mean visual analogue scale scores also significantly decreased (P < 0.01). These data suggest that evaluation of moisturising products for dryness prevention can be performed in cultured cells, since products that performed well in vitro also showed good efficacy for symptoms of dry mouth. The micro-gel spray was particularly effective for relieving symptoms of dry mouth in patients with cancer.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Ota Y,Morito A,Fujisawa K,Nishida M,Hata H,Ueno T,Yurikusa T,Murata Tdoi
10.1111/j.1365-2354.2012.01349.xsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
728-34issue
6eissn
0961-5423issn
1365-2354journal_volume
21pub_type
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