Gemcitabine and carboplatin in the treatment of transitional cell carcinoma of the urothelium: a single centre experience and review of the literature.

Abstract:

:The objectives of this study are to evaluate patient outcomes in clinical practice using gemcitabine and carboplatin (GCarbo) as first-line treatment in metastatic transitional cell carcinoma (TCC) of the urothelium, and to review the published evidence on the use of GCarbo in this setting. From July 2003, all cases of metastatic TCC of the urothelium referred to a single consultant were treated using 3-weekly gemcitabine 1200 mg/m(2) i.v. days 1 and 8 plus carboplatin AUC 5-6 i.v. day 1 to a maximum of six cycles. Fifteen patients (median age 67 years) were treated. Grade 3 or 4 toxicity included neutropenia (47%), anaemia (27%) and thrombocytopenia (20%). No patients required admission for neutropenic pyrexia/sepsis, and there were no treatment-related deaths. The overall response rate was 67%. The median survival was 9 months (95% CI 7.4-10.6), and 1-year survival 42%. Gemcitabine and carboplatin is well tolerated, and has activity as first-line treatment in metastatic TCC of the urothelium. However, there is now evidence suggesting that gemcitabine and cisplatin may be more efficacious, and until the appropriate randomized phase 3 trials have been carried out, gemcitabine and cisplatin should probably remain the preferred first-line therapy. Gemcitabine and carboplatin is an effective alternative in those patients not deemed fit enough for cisplatin.

authors

Hudson E,Lester JF

doi

10.1111/j.1365-2354.2008.01050.x

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

324-8

issue

3

eissn

0961-5423

issn

1365-2354

pii

ECC1050

journal_volume

19

pub_type

杂志文章,评审
  • An evaluation of the cost-effectiveness of the different palliative care models available to cancer patients in Turkey.

    abstract:BACKGROUND:Three different models are commonly used to provide palliative care services to cancer patients in Turkey: comprehensive palliative care center (CPCC), hospital inpatient services (HIS) and home healthcare (HHC). OBJECTIVES:The purpose of this study was to evaluate the cost-effectiveness of three alternativ...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.13110

    authors: Saygili M,Çelik Y

    更新日期:2019-09-01 00:00:00

  • No evidence of association between psychological distress and pain relief in patients with bone metastases from castration-resistant prostate cancer treated with 223Radium.

    abstract:OBJECTIVE:Painful bone metastases cause reduced quality of life (QoL) in patients with castration-resistant prostate cancer (CRPC). Alpha-emitter 223Radium is associated with a clear survival benefit and significant bone pain palliation in CRPC patients with symptomatic bone metastases. The aim of this study was to eva...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.13112

    authors: De Vincentis G,Frantellizzi V,Follacchio GA,Farcomeni A,Pani A,Samaritani R,Schinzari G,Santini D,Cortesi E

    更新日期:2019-09-01 00:00:00

  • Evaluation of the safety and effectiveness of prostate-specific antigen (PSA) monitoring in primary care after discharge from hospital-based follow-up following prostate cancer treatment.

    abstract:OBJECTIVE:To examine follow-up procedures after men are discharged into primary care following prostate cancer and highlight any areas for service improvement. METHODS:Patient record data from two Greater Manchester boroughs were retrieved retrospectively to investigate discharge instructions and monitoring adherence....

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.13389

    authors: Johnson H,Taylor S,Peat S,Booker J,Yorke J

    更新日期:2020-12-18 00:00:00

  • Is doctors' ability to identify cancer patients' worry and wish for information related to doctors' self-efficacy with regard to communicating about difficult matters?

    abstract::The aims were to investigate whether: (A) doctors' ability to identify patients' worry about prognosis/wish for information about disease and treatment is related to doctors' self-efficacy with regard to communicating about difficult matters and patients' satisfaction with a consultation/hope to live a good life in sp...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.2006.00670.x

    authors: Fröjd C,Von Essen L

    更新日期:2006-09-01 00:00:00

  • The effect of psychological interventions on quality of life in patients with head and neck cancer: A systematic review and meta-analysis.

    abstract::This systematic review and meta-analysis aimed to evaluate the effectiveness of psychological interventions in improving quality of life for head and neck cancer patients. Five databases were systematically searched in July 2016. Studies were included if they reported original empirical data from intervention studies ...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ecc.12789

    authors: Calver L,Tickle A,Moghaddam N,Biswas S

    更新日期:2018-01-01 00:00:00

  • Cancer, ageing, multimorbidity and primary care.

    abstract::Cancer care is complex, and made more so by multimorbidity and ageing. Multimorbidity affects all stages of cancer care from prevention and early detection through to end of life care. The effectiveness of cancer treatments in multimorbid patients may not be understood, as many conditions common in older people may be...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12717

    authors: Mazza D,Mitchell G

    更新日期:2017-05-01 00:00:00

  • Discussing potential recurrence after lung cancer surgery: Uncertainties and challenges.

    abstract::Patients with lung cancer who undergo surgery may potentially be cured. The resulting pathological staging gives an indication of 5-year survival and whether further treatment is recommended. To date, there is little research evidence regarding the way potential recurrence is communicated to patients by staff. This qu...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12870

    authors: Johnson M,Tod AM,Brummell S,Collins K

    更新日期:2018-09-01 00:00:00

  • Mechanisms of bone destruction in multiple myeloma.

    abstract::Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and mortality. It is the result of an increased activity of osteoclasts, which is not followed by reactive bone formation by osteoblasts. Recent studies have revealed no...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,评审

    doi:10.1111/ecc.12761

    authors: Terpos E,Christoulas D,Gavriatopoulou M,Dimopoulos MA

    更新日期:2017-11-01 00:00:00

  • Cancer patients' satisfaction with communication, information and quality of care in a UK region.

    abstract::Effective patient-professional communication can be of crucial importance to long-term psycho-social outcomes in patients with cancer. This study identifies patient satisfaction with regard to various aspects of communication and perceived quality of care. A well-validated questionnaire was administered to 435 cancer ...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.2005.00530.x

    authors: Davidson R,Mills ME

    更新日期:2005-03-01 00:00:00

  • Is it worth the wait? A survey of patients' satisfaction with an oncology outpatient clinic.

    abstract::Increasing numbers of cancer survivors and the tradition of long-term follow-up in the outpatient clinic has resulted in overcrowded oncology clinics and long waiting times. Little is known about patients' perceptions of their clinic attendance. This survey of 252 oncology patients investigated patients' satisfaction ...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.1997.tb00269.x

    authors: Thomas S,Glynne-Jones R,Chait I

    更新日期:1997-03-01 00:00:00

  • A qualitative study of anterior resection syndrome: the experiences of cancer survivors who have undergone resection surgery.

    abstract::This study aimed to explore how individuals recovered and adapted following surgical resection of their rectal cancer and the syndrome that occurs as a consequence of this operation. This syndrome, 'anterior resection syndrome', consists of frequency, urgency, fragmentation and incontinence of faeces, and is thought t...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2354.2005.00647.x

    authors: Desnoo L,Faithfull S

    更新日期:2006-07-01 00:00:00

  • Efficacy of a web-based cognitive rehabilitation intervention for adult cancer survivors: A pilot study.

    abstract::The purpose of this study was to evaluate the efficacy of a web-based cognitive rehabilitation intervention in survivors of adult-onset cancer and a sample of non-cancer community dwelling adults. Fifty-one participants were recruited and allocated to a cancer intervention group, a non-cancer intervention group, or a ...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ecc.12805

    authors: Mihuta ME,Green HJ,Shum DHK

    更新日期:2018-03-01 00:00:00

  • Translation and validation of the Polish version of the EORTC QLQ-OPT30 module for the assessment of health-related quality of life in patients with uveal melanoma.

    abstract::The purpose of this study was to translate into Polish and validate the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Ophthalmic Module (QLQ-OPT30). The QLQ-OPT30 was translated and pilot-tested according to EORTC guidelines. Patients were qualified based on the histo...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12001

    authors: Chmielowska K,Tomaszewski KA,Pogrzebielski A,Brandberg Y,Romanowska-Dixon B

    更新日期:2013-01-01 00:00:00

  • Advanced cancer patients' attitudes towards, and experiences with, screening for somatic mutations in tumours: a qualitative study.

    abstract::Somatic mutations in key oncogenes in non-small cell lung cancer (NSCLC) and melanoma are important determinants of tumour sensitivity to targeted therapies. Molecular screening for these predictive biomarkers is routinely used to inform treatment decisions; however, little is known about how best to communicate testi...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12600

    authors: Liang R,Meiser B,Smith S,Kasparian NA,Lewis CR,Chin M,Long GV,Ward R,Menzies AM,Harris-Wai JN,Kaur R

    更新日期:2017-11-01 00:00:00

  • Patients' preferences for video cassette recorded information: effect of age, sex and ethnic group.

    abstract::The emotional turmoil patients endure following a diagnosis of cancer can impair their ability to retain complex treatment-related information. Manoeuvres which increase the intensity of information have been shown to increase the amount retained. Providing details of treatment in a video format is one method of inten...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1046/j.1365-2354.1999.00123.x

    authors: Thomas R,Deary A,Kaminski E,Stockton D,De Zueew N

    更新日期:1999-06-01 00:00:00

  • Effectiveness of palliative care interventions offering social support to people with life-limiting illness-A systematic review.

    abstract::Individuals managing the challenges of life-limiting illness require adequate social support to maintain quality of life. Qualitative research reports that patients value highly the social support obtained in palliative care interventions such as day care and group therapies. This systematic review aims to summarise e...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,评审

    doi:10.1111/ecc.12837

    authors: Bradley N,Lloyd-Williams M,Dowrick C

    更新日期:2018-05-01 00:00:00

  • Measuring quality of life in oncology: is it worthwhile? I. Meaning, purposes and controversies.

    abstract::This is the first of a two-part paper on quality of life in cancer patients. This part examines some of the fundamental issues in health-related quality of life measurement with particular attention being given to cancer medicine, thus helping to focus the direction and methodological rigour required in future investi...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2354.1996.tb00228.x

    authors: Montazeri A,Gillis CR,McEwen J

    更新日期:1996-09-01 00:00:00

  • Does resilience 'buffer' against depression in prostate cancer patients? A multi-site replication study.

    abstract::Although psychological resilience has been shown to 'buffer' against depression following major stressors, no studies have reported on this relationship within the prostate cancer (PCa) population, many of whom are at elevated risk of depression, health problems and suicide. To investigate the effects of resilience up...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ecc.12170

    authors: Sharpley CF,Bitsika V,Wootten AC,Christie DR

    更新日期:2014-07-01 00:00:00

  • A qualitative exploration of the meaning of the term "survivor" to young women living with a history of breast cancer.

    abstract::There has been a recent increase in research considering the perceptions of the term "cancer survivor" held by individuals who have or have had cancer. This article explores the meaning of the term to young women living with a history of breast cancer. Twenty women participated in semi-structured interviews about thei...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12847

    authors: Rees S

    更新日期:2018-05-01 00:00:00

  • A cultural change in cancer education and training.

    abstract::Collaborative education and training is the only way forward for the cancer care work force. The Calman-Hine report has become the benchmark on which to build practice since its launch in 1995. A forward looking group--the Cancer Care Alliance of Teesside, South Durham and North Yorkshire Education Group and the Unive...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1046/j.1365-2354.2000.00189.x

    authors: Boal E,Hodgson D,Banks-Howe J,Husband G

    更新日期:2000-03-01 00:00:00

  • Undergoing head and neck cancer surgery: A grounded theory.

    abstract::Surgery is the treatment of choice in most head and neck cancers. Very often, the surgery is radical with high impact on the psychosocial, functional and aesthetic fields. The aim of this study is to gain a deeper understanding of the patient's, clinician's and key informant's point of view when surgery is proposed, t...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ecc.13062

    authors: Losi E,Guberti M,Ghirotto L,Di Leo S,Bassi MC,Costi S

    更新日期:2019-07-01 00:00:00

  • Meeting breast cancer patients' information needs during radiotherapy: what can we do to improve the information and support that is currently provided?

    abstract::Previous research has reported that patients require specific information relating to radiotherapy; however, these studies fail to describe patients' specific information needs over time. The aims of this study were to determine the specific information needs of breast cancer patients who are receiving radiotherapy an...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.2009.01090.x

    authors: Halkett GK,Kristjanson LJ,Lobb E,O'Driscoll C,Taylor M,Spry N

    更新日期:2010-07-01 00:00:00

  • Personality, coping strategies and emotional adjustment among Chinese cancer patients of different ages.

    abstract::Literature has documented personality and coping strategies as valuable intrapersonal resources for cancer adjustment among Caucasians. Nevertheless, it remains unclear whether these personal characteristics operate in a similar manner among cancer patients of different ages and cultural backgrounds. This study examin...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12781

    authors: You J,Wang C,Rodriguez L,Wang X,Lu Q

    更新日期:2018-01-01 00:00:00

  • Physical activity levels and supportive care needs for physical activity among breast cancer survivors with different psychosocial profiles: a cluster-analytical approach.

    abstract::The transition from breast cancer patient to survivor is associated with many treatment-related and psychosocial factors, which can influence health behaviour and associated needs. First, this study aimed to identify clusters of treatment-related and psychosocial factors among breast cancer survivors. Second, clusters...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.2012.01362.x

    authors: Charlier C,Pauwels E,Lechner L,Spittaels H,Bourgois J,DE Bourdeaudhuij I,VAN Hoof E

    更新日期:2012-11-01 00:00:00

  • Expectations and perspectives of ovarian cancer patients about cancer management in Romania. The international NOGGO-ENGOT trial: EXPRESSION III.

    abstract::We have investigated a relational model of expectations and preferences among ovarian cancer patients centred on physician-patient communication, treatment approach, and the need for information. Consecutive patients anonymously filled in the EXPRESSION III questionnaire between 2009 and 2012. Following descriptive st...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12566

    authors: Achimaş-Cadariu P,Iancu M,Kubelac P,Pop F,Braicu I,Vlad C,Oskay-Özcelik G,Sehouli J

    更新日期:2017-11-01 00:00:00

  • Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes.

    abstract:OBJECTIVE:Prehabilitation is increasingly being used to mitigate treatment-related complications and enhance recovery. An individual's state of health at diagnosis, including obesity, physical fitness and comorbidities, are influencing factors for the occurrence of adverse effects. This review explores whether prehabil...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.13023

    authors: Faithfull S,Turner L,Poole K,Joy M,Manders R,Weprin J,Winters-Stone K,Saxton J

    更新日期:2019-07-01 00:00:00

  • What is needed by staff to implement PROMs into routine oncology care? A qualitative study with the multi-disciplinary team.

    abstract:INTRODUCTION:The aim of this study was to identify strategies to implement patient-reported outcome measures (PROMs) into routine oncology outpatients' clinical care. METHODS:Qualitative focus groups were conducted with staff from multiple disciplines using a semistructured interview guide, with supporting data collec...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.13167

    authors: Roberts NA,Alexander K,Wyld D,Janda M

    更新日期:2019-11-01 00:00:00

  • Capturing users' experiences of participating in cancer trials.

    abstract::Randomized controlled trials are accepted to be the research design of choice to evaluate the effectiveness of health care interventions and are commonly used to evaluate cancer treatments. There are concerns, however, that levels of recruitment to trials are often much lower than anticipated, particularly in cancer t...

    journal_title:European journal of cancer care

    pub_type: 杂志文章,meta分析

    doi:10.1046/j.1365-2354.2002.00341.x

    authors: Donovan JL,Brindle L,Mills N

    更新日期:2002-09-01 00:00:00

  • Patients' perceptions of transrectal prostate biopsy: a qualitative study.

    abstract::This study explored men's experiences of transrectal prostate biopsy. Fifty men who had had a prostate biopsy talked about the experience as part of an in-depth interview; 36 were interviewed in 2000 about all aspects of prostate cancer, and 14 in 2005 about their experience of prostate-specific antigen testing, subse...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/j.1365-2354.2006.00766.x

    authors: Chapple AB,Ziebland S,Brewster S,McPherson A

    更新日期:2007-05-01 00:00:00

  • Chronic therapy with selective serotonin reuptake inhibitors and survival in newly diagnosed cancer patients.

    abstract::Depression might be associated with shorter disease specific survival. Selective serotonin reuptake inhibitors (SSRIs) were previously reported to increase the risk of certain malignancies. We aimed to evaluate the impact of SSRIs on cancer mortality. Five retrospective cohort studies were conducted in a UK population...

    journal_title:European journal of cancer care

    pub_type: 杂志文章

    doi:10.1111/ecc.12666

    authors: Boursi B,Lurie I,Haynes K,Mamtani R,Yang YX

    更新日期:2018-01-01 00:00:00