Abstract:
:The objectives of this study are to evaluate patient outcomes in clinical practice using gemcitabine and carboplatin (GCarbo) as first-line treatment in metastatic transitional cell carcinoma (TCC) of the urothelium, and to review the published evidence on the use of GCarbo in this setting. From July 2003, all cases of metastatic TCC of the urothelium referred to a single consultant were treated using 3-weekly gemcitabine 1200 mg/m(2) i.v. days 1 and 8 plus carboplatin AUC 5-6 i.v. day 1 to a maximum of six cycles. Fifteen patients (median age 67 years) were treated. Grade 3 or 4 toxicity included neutropenia (47%), anaemia (27%) and thrombocytopenia (20%). No patients required admission for neutropenic pyrexia/sepsis, and there were no treatment-related deaths. The overall response rate was 67%. The median survival was 9 months (95% CI 7.4-10.6), and 1-year survival 42%. Gemcitabine and carboplatin is well tolerated, and has activity as first-line treatment in metastatic TCC of the urothelium. However, there is now evidence suggesting that gemcitabine and cisplatin may be more efficacious, and until the appropriate randomized phase 3 trials have been carried out, gemcitabine and cisplatin should probably remain the preferred first-line therapy. Gemcitabine and carboplatin is an effective alternative in those patients not deemed fit enough for cisplatin.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Hudson E,Lester JFdoi
10.1111/j.1365-2354.2008.01050.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
324-8issue
3eissn
0961-5423issn
1365-2354pii
ECC1050journal_volume
19pub_type
杂志文章,评审abstract:BACKGROUND:Three different models are commonly used to provide palliative care services to cancer patients in Turkey: comprehensive palliative care center (CPCC), hospital inpatient services (HIS) and home healthcare (HHC). OBJECTIVES:The purpose of this study was to evaluate the cost-effectiveness of three alternativ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13110
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Painful bone metastases cause reduced quality of life (QoL) in patients with castration-resistant prostate cancer (CRPC). Alpha-emitter 223Radium is associated with a clear survival benefit and significant bone pain palliation in CRPC patients with symptomatic bone metastases. The aim of this study was to eva...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13112
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To examine follow-up procedures after men are discharged into primary care following prostate cancer and highlight any areas for service improvement. METHODS:Patient record data from two Greater Manchester boroughs were retrieved retrospectively to investigate discharge instructions and monitoring adherence....
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13389
更新日期:2020-12-18 00:00:00
abstract::The aims were to investigate whether: (A) doctors' ability to identify patients' worry about prognosis/wish for information about disease and treatment is related to doctors' self-efficacy with regard to communicating about difficult matters and patients' satisfaction with a consultation/hope to live a good life in sp...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00670.x
更新日期:2006-09-01 00:00:00
abstract::This systematic review and meta-analysis aimed to evaluate the effectiveness of psychological interventions in improving quality of life for head and neck cancer patients. Five databases were systematically searched in July 2016. Studies were included if they reported original empirical data from intervention studies ...
journal_title:European journal of cancer care
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ecc.12789
更新日期:2018-01-01 00:00:00
abstract::Cancer care is complex, and made more so by multimorbidity and ageing. Multimorbidity affects all stages of cancer care from prevention and early detection through to end of life care. The effectiveness of cancer treatments in multimorbid patients may not be understood, as many conditions common in older people may be...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12717
更新日期:2017-05-01 00:00:00
abstract::Patients with lung cancer who undergo surgery may potentially be cured. The resulting pathological staging gives an indication of 5-year survival and whether further treatment is recommended. To date, there is little research evidence regarding the way potential recurrence is communicated to patients by staff. This qu...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12870
更新日期:2018-09-01 00:00:00
abstract::Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and mortality. It is the result of an increased activity of osteoclasts, which is not followed by reactive bone formation by osteoblasts. Recent studies have revealed no...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12761
更新日期:2017-11-01 00:00:00
abstract::Effective patient-professional communication can be of crucial importance to long-term psycho-social outcomes in patients with cancer. This study identifies patient satisfaction with regard to various aspects of communication and perceived quality of care. A well-validated questionnaire was administered to 435 cancer ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2005.00530.x
更新日期:2005-03-01 00:00:00
abstract::Increasing numbers of cancer survivors and the tradition of long-term follow-up in the outpatient clinic has resulted in overcrowded oncology clinics and long waiting times. Little is known about patients' perceptions of their clinic attendance. This survey of 252 oncology patients investigated patients' satisfaction ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1997.tb00269.x
更新日期:1997-03-01 00:00:00
abstract::This study aimed to explore how individuals recovered and adapted following surgical resection of their rectal cancer and the syndrome that occurs as a consequence of this operation. This syndrome, 'anterior resection syndrome', consists of frequency, urgency, fragmentation and incontinence of faeces, and is thought t...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2005.00647.x
更新日期:2006-07-01 00:00:00
abstract::The purpose of this study was to evaluate the efficacy of a web-based cognitive rehabilitation intervention in survivors of adult-onset cancer and a sample of non-cancer community dwelling adults. Fifty-one participants were recruited and allocated to a cancer intervention group, a non-cancer intervention group, or a ...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/ecc.12805
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to translate into Polish and validate the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Ophthalmic Module (QLQ-OPT30). The QLQ-OPT30 was translated and pilot-tested according to EORTC guidelines. Patients were qualified based on the histo...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12001
更新日期:2013-01-01 00:00:00
abstract::Somatic mutations in key oncogenes in non-small cell lung cancer (NSCLC) and melanoma are important determinants of tumour sensitivity to targeted therapies. Molecular screening for these predictive biomarkers is routinely used to inform treatment decisions; however, little is known about how best to communicate testi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12600
更新日期:2017-11-01 00:00:00
abstract::The emotional turmoil patients endure following a diagnosis of cancer can impair their ability to retain complex treatment-related information. Manoeuvres which increase the intensity of information have been shown to increase the amount retained. Providing details of treatment in a video format is one method of inten...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1999.00123.x
更新日期:1999-06-01 00:00:00
abstract::Individuals managing the challenges of life-limiting illness require adequate social support to maintain quality of life. Qualitative research reports that patients value highly the social support obtained in palliative care interventions such as day care and group therapies. This systematic review aims to summarise e...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12837
更新日期:2018-05-01 00:00:00
abstract::This is the first of a two-part paper on quality of life in cancer patients. This part examines some of the fundamental issues in health-related quality of life measurement with particular attention being given to cancer medicine, thus helping to focus the direction and methodological rigour required in future investi...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.1996.tb00228.x
更新日期:1996-09-01 00:00:00
abstract::Although psychological resilience has been shown to 'buffer' against depression following major stressors, no studies have reported on this relationship within the prostate cancer (PCa) population, many of whom are at elevated risk of depression, health problems and suicide. To investigate the effects of resilience up...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.12170
更新日期:2014-07-01 00:00:00
abstract::There has been a recent increase in research considering the perceptions of the term "cancer survivor" held by individuals who have or have had cancer. This article explores the meaning of the term to young women living with a history of breast cancer. Twenty women participated in semi-structured interviews about thei...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12847
更新日期:2018-05-01 00:00:00
abstract::Collaborative education and training is the only way forward for the cancer care work force. The Calman-Hine report has become the benchmark on which to build practice since its launch in 1995. A forward looking group--the Cancer Care Alliance of Teesside, South Durham and North Yorkshire Education Group and the Unive...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2000.00189.x
更新日期:2000-03-01 00:00:00
abstract::Surgery is the treatment of choice in most head and neck cancers. Very often, the surgery is radical with high impact on the psychosocial, functional and aesthetic fields. The aim of this study is to gain a deeper understanding of the patient's, clinician's and key informant's point of view when surgery is proposed, t...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.13062
更新日期:2019-07-01 00:00:00
abstract::Previous research has reported that patients require specific information relating to radiotherapy; however, these studies fail to describe patients' specific information needs over time. The aims of this study were to determine the specific information needs of breast cancer patients who are receiving radiotherapy an...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2009.01090.x
更新日期:2010-07-01 00:00:00
abstract::Literature has documented personality and coping strategies as valuable intrapersonal resources for cancer adjustment among Caucasians. Nevertheless, it remains unclear whether these personal characteristics operate in a similar manner among cancer patients of different ages and cultural backgrounds. This study examin...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12781
更新日期:2018-01-01 00:00:00
abstract::The transition from breast cancer patient to survivor is associated with many treatment-related and psychosocial factors, which can influence health behaviour and associated needs. First, this study aimed to identify clusters of treatment-related and psychosocial factors among breast cancer survivors. Second, clusters...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2012.01362.x
更新日期:2012-11-01 00:00:00
abstract::We have investigated a relational model of expectations and preferences among ovarian cancer patients centred on physician-patient communication, treatment approach, and the need for information. Consecutive patients anonymously filled in the EXPRESSION III questionnaire between 2009 and 2012. Following descriptive st...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12566
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Prehabilitation is increasingly being used to mitigate treatment-related complications and enhance recovery. An individual's state of health at diagnosis, including obesity, physical fitness and comorbidities, are influencing factors for the occurrence of adverse effects. This review explores whether prehabil...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13023
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to identify strategies to implement patient-reported outcome measures (PROMs) into routine oncology outpatients' clinical care. METHODS:Qualitative focus groups were conducted with staff from multiple disciplines using a semistructured interview guide, with supporting data collec...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13167
更新日期:2019-11-01 00:00:00
abstract::Randomized controlled trials are accepted to be the research design of choice to evaluate the effectiveness of health care interventions and are commonly used to evaluate cancer treatments. There are concerns, however, that levels of recruitment to trials are often much lower than anticipated, particularly in cancer t...
journal_title:European journal of cancer care
pub_type: 杂志文章,meta分析
doi:10.1046/j.1365-2354.2002.00341.x
更新日期:2002-09-01 00:00:00
abstract::This study explored men's experiences of transrectal prostate biopsy. Fifty men who had had a prostate biopsy talked about the experience as part of an in-depth interview; 36 were interviewed in 2000 about all aspects of prostate cancer, and 14 in 2005 about their experience of prostate-specific antigen testing, subse...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00766.x
更新日期:2007-05-01 00:00:00
abstract::Depression might be associated with shorter disease specific survival. Selective serotonin reuptake inhibitors (SSRIs) were previously reported to increase the risk of certain malignancies. We aimed to evaluate the impact of SSRIs on cancer mortality. Five retrospective cohort studies were conducted in a UK population...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12666
更新日期:2018-01-01 00:00:00