Abstract:
:The study aimed to evaluate cancer-targeting potential of a newly synthesised radiopharmaceutical, 99m Tc-resveratrol in vivo, using colon cancer model. Colon cancer was induced in 20 male Sprague-Dawley rats by subcutaneous administration of 1,2-dimethylhydrazine (DMH), dissolved in 1 mM EDTA-normal saline, at a dose of 30 mg/kg body weight twice a week for first 4 weeks and once a week for next 12 weeks. A control group containing normal rats was used for result comparison. Colon cancer in DMH-treated group was confirmed by gross analysis of the colon, by histopathological analysis and molecular marker study in tumour tissue. At the end of the treatment period, the animals from the two groups were used for bio-distribution evaluation of 99m Tc-resveratrol at different time intervals. High uptake of 99m Tc-resveratrol was recorded in rat liver, spleen and kidneys, and the ratio of colon tumour uptake to normal colon uptake in DMH-treated rats increased significantly (P ≤ 0.01) with time, to reach a maximum value at 2 h but decreased thereafter. High uptake at the tumour site as compared to normal colon tissue was observed; however, the uptake by cancer cells at the target site was limited by high reticulo-endothelial uptake and rapid metabolism.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Kamal R,Dhawan DK,Chadha VDdoi
10.1111/ecc.12504subject
Has Abstractpub_date
2017-09-01 00:00:00issue
5eissn
0961-5423issn
1365-2354journal_volume
26pub_type
杂志文章abstract::Haematological cancers are becoming more prevalent, however, survival is also increasing. Many survivors are faced with psychosocial issues after treatment ends, and they may not receive the support they need. This review aims to examine peer reviewed literature reporting psychosocial distress faced by haematological ...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/ecc.12640
更新日期:2017-11-01 00:00:00
abstract::Female partners of prostate cancer (PCa) survivors experience heightened psychological distress that may be greater than that expressed by PCa patients. However, optimal approaches to detect distressed, or at risk of distress, partners are unclear. This study applied receiver operating characteristics analysis to eval...
journal_title:European journal of cancer care
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abstract::Although uterine prolapse and carcinoma of the uterine cervix are not rare event, their association is very uncommon. An 86-year-old patient gravida 8, para 5 was admitted for vaginal bleeding from a uterine prolapse of 20 years of duration. On physical examination, a complete third-degree prolapsed uterus with an ulc...
journal_title:European journal of cancer care
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doi:10.1111/j.1365-2354.2008.01010.x
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abstract::To investigate health professionals' perspectives about factors that impede or facilitate cancer care for Indigenous people. Semi-structured interviews with 22 health professionals involved in Indigenous cancer care. Data were interpreted using an inductive thematic analysis approach. Participants presented their pers...
journal_title:European journal of cancer care
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abstract::The concept of clinical supervision has received considerable attention in the nursing literature of late, enjoying favour not only with many practitioners and managers, but academics and policy makers alike. The following paper considers the utility of clinical supervision within the cancer nursing setting, concentra...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.1996.tb00205.x
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abstract::Constipation and the laxatives polyethylene glycol (PEG), sodium picosulphate (SPS) and lactulose (L) were investigated in outpatients with cancer and on opioid therapy. Randomly selected patients were enrolled in a prospective, controlled, open-label trial. Endpoints were number of patients taking laxatives >28 days,...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
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abstract::The aim of this study was to evaluate satisfaction with the National Cancer Screening Programme of mammography in Korea and to examine the association between subscales of satisfaction and general satisfaction. We conducted a cross-sectional telephone survey for women who had obtained a National Cancer Screening Progr...
journal_title:European journal of cancer care
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abstract::This study aims to describe the experiences of nurses caring for cancer patients in non-specialist wards. The study was conducted in a large (420 beds) and small (32 beds) hospital in an area health service with urban and rural populations in the west of Sydney. A qualitative descriptive approach was utilized to colle...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2354.2005.00566.x
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abstract::Chemotherapy side effects (CSE) have a strong impact on patients' quality of life (QOL). To assess patient perceptions of CSE, their impact on QOL and doctor-patient communication regarding these aspects, a survey was conducted among Italian cancer patients. Patients at least 18 years of age, who received chemotherapy...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12618
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Fear of cancer recurrence (FCR) is the most commonly reported problem and unmet need among breast cancer survivors. The aim of this qualitative study was to explore the experience of recurrence fears among Taiwanese breast cancer survivors. METHODS:Three focus groups were included in this study. A purposive ...
journal_title:European journal of cancer care
pub_type: 杂志文章
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journal_title:European journal of cancer care
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13200
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abstract::Duodeno-pancreatic neuroendocrine tumours (DP-ETs) are increasingly diagnosed today due to the widespread use of modern imaging methods. Duodeno-pancreatic endocrine tumours should be treated by radical surgical resection, which offers a high chance for cure when the disease is localized. A high index of suspicion is ...
journal_title:European journal of cancer care
pub_type: 杂志文章
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journal_title:European journal of cancer care
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更新日期:2018-01-01 00:00:00
abstract::To enable demand-based palliative care, it is important to know the perceptions of terminally ill patients and their family members regarding home and hospice as places of care at the end of life. Eight women and five men suffering from cancer and with a life expectancy of 3 months or less were interviewed. In each ca...
journal_title:European journal of cancer care
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
abstract::When two or more persons, e.g. nurses and patients, act together interaction takes place. The expectations of nurses and their definition of the patient's illness status affect their behaviour towards the patient and how they practice nursing. The aim of this study was to examine the interaction between adults with le...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1998.00063.x
更新日期:1998-03-01 00:00:00
abstract::The aim of this study was to describe family members' life situation and experiences of care in two different care settings, the patient's home or in hospital during the acute post-transplantation phase after allogeneic haematopoietic stem cell transplantation (HSCT). Data were collected through semi-structured interv...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12610
更新日期:2018-01-01 00:00:00
abstract::A retrospective analysis of first-time enquirers using a cancer information service in Belfast, Northern Ireland, is presented. Our results show that women are three times more likely to use the service than men, with relatives and friends more likely to seek information on behalf of cancer patients than patients them...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2002.00299.x
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journal_title:European journal of cancer care
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journal_title:European journal of cancer care
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journal_title:European journal of cancer care
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abstract::Delays in the diagnosis of cancer are common, and they are attributed to both patient and healthcare system factors. Minimizing such delays and improving early detection rates is a key goal of the new cancer reform strategy in England, in light of recent data showing that survival rates in the UK are low. The aim of t...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
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journal_title:European journal of cancer care
pub_type: 杂志文章,评审
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abstract::Fatigue--which is a complex, multicausal, and multidimensional subjective experience--is today the most frequently reported symptom from patients with cancer. The aim of this study was to explore the experience of fatigue in cancer patients and to describe the categories and dimensions of the symptoms. A qualitative m...
journal_title:European journal of cancer care
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doi:10.1046/j.1365-2354.1999.00168.x
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abstract::While colorectal cancer is the most common cancer affecting both men and women in Australia, disease-specific peer support services are lacking. This study examined the acceptability and preferred models of peer support among people with colorectal cancer. First, a mixed-method study examined enablers and barriers to ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2010.01218.x
更新日期:2011-07-01 00:00:00
abstract::Informational need assessment has become an important part of health care in order to provide information effectively in clinical settings. Literature on information needs in the West suggests that breast cancer (BC) patients needed more information than doctors had provided, and information that fully met their needs...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2008.00936.x
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journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2011.01280.x
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abstract:OBJECTIVE:Oesophagectomy for cancer is associated with significant morbidity and mortality, and reduced quality of life. Structured rehabilitation potentially offers improved physical and psychological outcomes. We aimed to explore patient, carer and healthcare provider attitudes and preferences towards the role of reh...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12996
更新日期:2019-03-01 00:00:00
abstract::Research indicates there is confusion in the minds of patients and the public surrounding the issue of 'informed consent'. This confusion is compounded when patients are asked to participate in a clinical trial. This study aimed to survey, by self-completed postal questionnaires, the experiences and opinions of 100 ra...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1994.tb00037.x
更新日期:1994-12-01 00:00:00