Abstract:
:In order to improve outcomes, identification of the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) genes has become crucial in advanced non-small-cell lung cancer (NSCLC). The aim of the present study is to analyse time trends and frequency of testing, factors affecting testing as well as prevalence of mutations in the Swiss population. We analysed EGFR and ALK testing in a cohort of patients with newly diagnosed metastasised non-squamous NSCLC in the catchment area of the cancer registry Eastern Switzerland in the years 2008-2014. We analysed prevalence of mutations and studied clinicopathological characteristics and survival of tested and non-tested patients and of patients with and without mutations. Among 718 patients identified, 11% (51/447) harboured an EGFR mutation in the exons 18, 19 or 21 and further 12% (31/265) showed a positive test result for ALK rearrangements. In non-smokers the proportions of mutations were 31% and 23% respectively. Testing rates increased over time and reached 79% in 2014. We observed significantly lower testing rates and poorer survival in elderly, patients with limited life expectancy and patients treated at hospitals not involved in clinical research. Outcomes can be further improved in a considerable proportion of patients with advanced non-squamous NSCLC.
journal_name
Eur J Cancer Care (Engl)journal_title
European journal of cancer careauthors
Ess SM,Herrmann C,Frick H,Krapf M,Cerny T,Jochum W,Früh Mdoi
10.1111/ecc.12721subject
Has Abstractpub_date
2017-11-01 00:00:00issue
6eissn
0961-5423issn
1365-2354journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:Oesophagectomy for cancer is associated with significant morbidity and mortality, and reduced quality of life. Structured rehabilitation potentially offers improved physical and psychological outcomes. We aimed to explore patient, carer and healthcare provider attitudes and preferences towards the role of reh...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12996
更新日期:2019-03-01 00:00:00
abstract::This study was undertaken to gain insight in the views and experiences of oncology healthcare providers in Flanders, the Dutch-speaking part of Belgium, on caring for patients of non-Western descent. A qualitative research design with the constant comparative method was used. Data were collected through five focus gro...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12481
更新日期:2017-11-01 00:00:00
abstract::The need for information by the caregiving family of an adult patient with cancer has been identified by research. This paper is a literature review of the information and learning needs of caregiving relatives. By meeting these needs the health care professional is able to help support the family, and therefore the p...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.1995.tb00068.x
更新日期:1995-09-01 00:00:00
abstract::The purpose of this paper is to compare the coping processes of hospital chaplains and nurses in cancer care and to discuss the findings in relation to work and stress in a multidisciplinary team. The results of the research question--'what coping processes are used when confronting existential issues?'--reveal that, ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2007.00801.x
更新日期:2008-01-01 00:00:00
abstract::This study examined the effect of an integrated yoga programme on chemotherapy-related nausea and emesis in early operable breast cancer outpatients. Sixty-two subjects were randomly allocated to receive yoga (n = 28) or supportive therapy intervention (n = 34) during the course of their chemotherapy. Both groups had ...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2354.2006.00739.x
更新日期:2007-11-01 00:00:00
abstract::Although it is quite rare, second primary neoplasms in cancer patients may present with the signs and symptoms of malignant spinal cord compression. Primary spinal cord tumours in the cancer patients may be deceptive and considered as the recurrent first cancer. Therefore, it should be precisely differentiated and app...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2006.00708.x
更新日期:2006-12-01 00:00:00
abstract::Somatic mutations in key oncogenes in non-small cell lung cancer (NSCLC) and melanoma are important determinants of tumour sensitivity to targeted therapies. Molecular screening for these predictive biomarkers is routinely used to inform treatment decisions; however, little is known about how best to communicate testi...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12600
更新日期:2017-11-01 00:00:00
abstract::The issues surrounding nurses and their use of research are many and complex. Experience in a newly developing area of nursing--the management of lymphodema--has revealed three key reasons why nurses do not, on the whole, use the research process to answer clinical problems or use the results of research to change cli...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1994.tb00015.x
更新日期:1994-06-01 00:00:00
abstract::The third European Commission action plan to combat cancer recognized the need to develop effective continuing and in-service training programmes for doctors, nurses and other healthcare professionals. A literature review and course documentary analysis commissioned by the English National Board for Nursing, Midwifery...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2001.00262.x
更新日期:2001-09-01 00:00:00
abstract::This study explored men's experiences of transrectal prostate biopsy. Fifty men who had had a prostate biopsy talked about the experience as part of an in-depth interview; 36 were interviewed in 2000 about all aspects of prostate cancer, and 14 in 2005 about their experience of prostate-specific antigen testing, subse...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2006.00766.x
更新日期:2007-05-01 00:00:00
abstract::Open learning is increasing in importance in nurse education. In this article the author considers open learning and discusses its use in palliative care education. Advantages and disadvantages of this learning method are considered and guidelines are offered to the teacher to assist them to evaluate existing learning...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1994.tb00028.x
更新日期:1994-09-01 00:00:00
abstract::Effective patient-professional communication can be of crucial importance to long-term psycho-social outcomes in patients with cancer. This study identifies patient satisfaction with regard to various aspects of communication and perceived quality of care. A well-validated questionnaire was administered to 435 cancer ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2005.00530.x
更新日期:2005-03-01 00:00:00
abstract::Collaborative education and training is the only way forward for the cancer care work force. The Calman-Hine report has become the benchmark on which to build practice since its launch in 1995. A forward looking group--the Cancer Care Alliance of Teesside, South Durham and North Yorkshire Education Group and the Unive...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2000.00189.x
更新日期:2000-03-01 00:00:00
abstract::Research indicates there is confusion in the minds of patients and the public surrounding the issue of 'informed consent'. This confusion is compounded when patients are asked to participate in a clinical trial. This study aimed to survey, by self-completed postal questionnaires, the experiences and opinions of 100 ra...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.1994.tb00037.x
更新日期:1994-12-01 00:00:00
abstract::Previous reports on the patient perspective of daily life during a 1-year high-grade glioma (HGG) trajectory from the time of diagnosis are sparse. The aim of this longitudinal mixed methods study is to identify the specific needs and preferences for rehabilitation and supportive care and how it links with physical ac...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12806
更新日期:2018-03-01 00:00:00
abstract::Surgery is the treatment of choice in most head and neck cancers. Very often, the surgery is radical with high impact on the psychosocial, functional and aesthetic fields. The aim of this study is to gain a deeper understanding of the patient's, clinician's and key informant's point of view when surgery is proposed, t...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.13062
更新日期:2019-07-01 00:00:00
abstract::The aim of this prospective multi-centre study was to evaluate the level of psychological distress (PD) and adjustment to disease in patients who underwent radical prostatectomy. Furthermore, the impact of urinary incontinence and erectile dysfunction on PD was assessed. Anxiety, depression and PD were evaluated using...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/ecc.12186
更新日期:2014-11-01 00:00:00
abstract::Female partners of prostate cancer (PCa) survivors experience heightened psychological distress that may be greater than that expressed by PCa patients. However, optimal approaches to detect distressed, or at risk of distress, partners are unclear. This study applied receiver operating characteristics analysis to eval...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12924
更新日期:2019-01-01 00:00:00
abstract::The aim of this study is to explore, from a medical sociological perspective, the use of complementary therapies by palliative care nurses. This paper shows how the conceptual vocabulary developed by Giddens [Giddens A. (1990) The Consequences of Modernity. Polity Press, Cambridge; Giddens A. (1991) Modernity and Self...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.2003.00381.x
更新日期:2003-06-01 00:00:00
abstract::This study aims to describe the experiences of nurses caring for cancer patients in non-specialist wards. The study was conducted in a large (420 beds) and small (32 beds) hospital in an area health service with urban and rural populations in the west of Sydney. A qualitative descriptive approach was utilized to colle...
journal_title:European journal of cancer care
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2354.2005.00566.x
更新日期:2005-07-01 00:00:00
abstract::The emotional turmoil patients endure following a diagnosis of cancer can impair their ability to retain complex treatment-related information. Manoeuvres which increase the intensity of information have been shown to increase the amount retained. Providing details of treatment in a video format is one method of inten...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1046/j.1365-2354.1999.00123.x
更新日期:1999-06-01 00:00:00
abstract::Cancer-related fatigue (CRF) is a burdensome symptom for breast cancer (BC) patients. In this pilot study, we tested several questionnaires as predictors for treatment responsiveness, along with the implementation of a multimodal therapy concept consisting of sleep, psycho-education, eurythmy, painting therapy and sta...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12278
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:Documentations of the experiences of patients with advanced prostate cancer and their partners are sparse. Views of care and treatment received for metastatic castrate-resistant prostate cancer (mCRPC) are presented here. METHODS:Structured interviews conducted within 14 days of a systemic therapy for mCRPC ...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.13140
更新日期:2019-11-01 00:00:00
abstract::This narrative review of the literature examines the issues influencing chemotherapy treatment of older patients with cancer. Increasing age is associated with physical, social and psychological changes, but the rate of change differs widely between people, such that chronological age is not a good determinant of fitn...
journal_title:European journal of cancer care
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2354.2011.01294.x
更新日期:2012-01-01 00:00:00
abstract::Research on physical activity for cancer survivors suggests a relationship with improved quality of life. The aim of this study was to explore if there was also a relationship of physical activity with sleep difficulties and fatigue, common effects of cancer and its treatments. Recruitment was by posters and flyers in...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2009.01126.x
更新日期:2010-11-01 00:00:00
abstract::Although several studies have reported the impact of oesophagectomy on health-related quality of life (HRQOL), none has objectively assessed its impact on physical fitness. This study aimed to evaluate the impact of oesophagectomy on physical fitness and HRQOL in patients with oesophageal cancer. In this prospective s...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12030
更新日期:2013-05-01 00:00:00
abstract::Patients commonly develop shoulder disability and reduction in quality of life (QOL) following neck dissection surgery. There is a lack of studies investigating the impact of preventative rehabilitation to prevent shoulder disability in this population. An exploratory trial was undertaken to investigate this gap in th...
journal_title:European journal of cancer care
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2354.2009.01149.x
更新日期:2011-01-01 00:00:00
abstract::This paper reports on a study into male participation in cancer support groups, which elicited data on the impact of cancer on masculinities. This small qualitative pilot study, which took place in Belfast in Northern Ireland, involved semi-structured interviews with eight men with a history of cancer who were no long...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2009.01085.x
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE/BACKGROUND:Discussion of treatment goals between oncologists and patients is challenging. Patients frequently misunderstand goals of therapy. There are several methods to document goals of chemotherapy, however, and are frequently not incorporated into patient charts. METHODS/DESIGN:Cancer patients receiving...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/ecc.12973
更新日期:2019-03-01 00:00:00
abstract::Discharge from hospital follow-up is a key time point in the cancer journey. With recommendations for earlier discharge of cancer survivors, attention to the discharge process is likely to become increasingly important. This study explored cancer survivors' experiences of discharge from hospital follow-up. Survivors o...
journal_title:European journal of cancer care
pub_type: 杂志文章
doi:10.1111/j.1365-2354.2011.01312.x
更新日期:2012-05-01 00:00:00