[Retrospective analysis of adverse side-effects of medication in elderly patients at a primary care health centre].

Abstract:

OBJECTIVE:To describe the adverse drug events (ADEs) reported by doctors of a primary health care centre in the patient's medical record. DESIGN:A retrospective, descriptive study. SETTING:Burriana Health Centre (Castellón), Spain. PARTICIPANTS:All patients over 75 with a clinical history held on paper at the health centre, ie non-institutionalized patients seen on an out-patient basis, were checked. MEASUREMENTS:A total of 2044 paper-based medical records were analysed, in which 832 histories describing 1893 ADEs (90.4% unforeseen and 9.6% preventable) were found. This means that 41% of the patients experienced one or more adverse events, with an average of 2.28 ADEs per patient. RESULTS:Most ADEs (85.3%) were light, but 6% were classified as serious, with high digestive haemorrhage caused by NSAIDs standing out as the most common serious problem (37.3%). The pharmaco-therapeutic groups most involved in ADEs were cardiovascular therapy (29.4%), anti-infectious drugs (21.2%) and nervous system drugs (20.1%). Seventeen cases of intoxication were detected (0.9% total ADEs), with digoxin responsible for 67% of the serious intoxications. It was observed that ADEs occur with statistical significance most frequently in women (OR, 1.73; 95% CI, 1.42-2.10). After an age-stratified analysis, it was concluded that the only sub-group where the increase in risk was not significant was the group of people over 85 years old. CONCLUSIONS:ADEs create a serious public health problem, with negative effects on patients. Although most ADEs are unforeseen (90.4%), it is still worrying that 9.6% of the ADEs identified are preventable.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Alós Almiñana M,Bonet Deán M

doi

10.1157/13116153

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

75-80

issue

2

eissn

0212-6567

issn

1578-1275

pii

13116153

journal_volume

40

pub_type

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