Substance P-like immunoreactivity and somatostatin-like immunoreactivity in the ventricular fluid of patients with chronic pain syndromes.

Abstract:

:Substance P-like and somatostatin-like immunoreactivities (SPLI and SLI) were determined in ventricular fluid of patients with chronic pain syndromes and in a comparison group with multiple sclerosis, essential tremor, epilepsy and postanoxic myoclonus. Concentrations of SPLI and SLI were non-significantly decreased by 40% and 33% in chronic pain patients as compared with control patients without pain. There were no differences apparent between subgroups of pain patients (deafferentation pain, neoplasia-induced pain, thalamic pain). High pressure liquid chromatography combined with radioimmunoassay showed marked heterogeneity of SPLI and SLI.

authors

Jost S,Reuner C,Geiger J,Mohadjer M,Milios E,Cramer H

doi

10.1007/BF02191152

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

109-12

issue

2

eissn

0940-1334

issn

1433-8491

journal_volume

241

pub_type

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