Deterioration on magnetic resonance imaging despite good clinical recovery after viral encephalitis.

Abstract:

:We present a 2-year-old patient who showed progressive widespread white-matter abnormalities on magnetic resonance imaging 1 month after viral encephalitis, despite her good clinical recovery. These lesions on magnetic resonance imaging had not responded to therapies commonly used to treat secondary immune-mediated demyelinating lesions, as observed in acute disseminated encephalomyelitis. Acute viral encephalitis caused cortical blindness, but no other clinical signs developed during her clinical course. The progressive white-matter lesion in our case was different from the exacerbation of viral encephalitis or secondary immune-mediated encephalitis. A year later, magnetic resonance imaging-demonstrated brain atrophy with cystic changes in the bilateral occipital area, with remarkably reduced white-matter lesions. We hypothesize that the progressive white-matter changes resulted from the process of atrophy, degeneration, and cystic formation after viral encephalitis, rather than from the immune-mediated demyelinating process.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Awaya T,Kato T,Shibata M,Yamanaka Y,Nakahata T

doi

10.1016/j.pediatrneurol.2007.10.010

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

218-20

issue

3

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(07)00543-7

journal_volume

38

pub_type

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