Abstract：
:Limited data are available on optic neuritis in Asian children. Clinical profiles tend to vary with different races. We aimed to determine the clinical manifestations, visual outcomes, and etiologies of optic neuritis in Malaysian children, and discuss the literature of optic neuritis in Asian children. A retrospective study involving 14 children with optic neuritis was performed at Hospital Universiti Sains Malaysia between July 2005 and January 2010 (follow-up, 18-60 months). Clinical features, laboratory results, possible etiologies, and visual acuity after 1 year were studied. Females were predominant (mean age at presentation, 11.1 years). All patients manifested bilateral involvement. Swollen optic discs were observed in 92.9% of eyes; 60.7% of patients demonstrated a visual acuity of 6/60 (or 20/200) or worse on presentation, whereas 14.3% remained at 6/60 (or 20/200) or worse, 1 year after their attack. Cecocentral scotoma comprised the most common visual field defect. Infection contributed to 50.0% of cases; 14.3% progressed to multiple sclerosis during follow-up, with no evidence of recurrent optic neuritis. The clinical profiles and etiologies of optic neuritis in Malay children differ slightly compared with other optic neuritis studies of Asian children. The frequency of progression to multiple sclerosis is relatively lower.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Shatriah I,Adlina AR,Alshaarawi S,Wan-Hitam WHdoi
10.1016/j.pediatrneurol.2012.02.020subject
Has Abstractpub_date
2012-05-01 00:00:00pages
293-7issue
5eissn
0887-8994issn
1873-5150pii
S0887-8994(12)00074-4journal_volume
46pub_type
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journal_title：Pediatric neurology
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pub_type： 杂志文章
doi：10.1016/j.pediatrneurol.2005.01.012
更新日期：2005-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1991-03-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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