MRI signal changes in the white matter after corpus callosotomy.

Abstract:

:Magnetic resonance imaging (MRI) changes reported after corpus callosotomy include hyperintensity in the corpus callosum, perifalcine hyperintensity caused by surgical retraction, and acute changes associated with surgical complications. The authors have observed MRI signal changes in the cerebral white matter of corpus callosotomy patients that are separate from the sectioned callosum and not clearly related to surgical manipulation or injury. Brain MRI scans were retrospectively reviewed in 25 of 38 patients who underwent anterior, posterior, or total callosotomy for refractory seizures between 1988 and 1995. Nine patients had signal changes in the cerebral white matter on postoperative MRI. Six of these patients had preoperative MRI studies available for comparison, and none of the white matter signal abnormalities were evident preoperatively. T2 prolongation or hyperintensity on proton-density images was observed in areas including the centrum semiovale, forceps major, and forceps minor. Three patients had signal changes that had distinct borders extending only to the posterior limit of the callosotomy. MRI signal changes in the cerebral white matter after corpus callosotomy have not been previously reported and may represent distant effects of callosal section. Wallerian degeneration occurring in the neuronal processes cut during surgery could account for the signal changes.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Khurana DS,Strawsburg RH,Robertson RL,Madsen JR,Helmers SL

doi

10.1016/s0887-8994(99)00082-x

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

691-5

issue

4

eissn

0887-8994

issn

1873-5150

pii

S088789949900082X

journal_volume

21

pub_type

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