Abstract:
:This study reports on a patient with Leigh syndrome with a T-to-C mutation at nucleotide 8993 of mitochondrial deoxyribonucleic acid (T8993C). The authors reviewed 10 Leigh syndrome patients, including ours, with T8993C. Compared with 18 reported patients with Leigh syndrome caused by a T-to-G mutation at nucleotide 8993 (T8993G), Leigh syndrome with T8993C was characterized by a significantly higher frequency of ataxia (P < 0.01). None of the reviewed T8993C-associated Leigh syndrome patients had retinitis pigmentosa, which is one of the characteristic findings in Leigh syndrome with T8993G. The milder symptoms of T8993C-Leigh syndrome can be explained by the milder complex V dysfunction; however, the higher frequency of ataxia in T8993C-Leigh syndrome requires more study.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Fujii T,Hattori H,Higuchi Y,Tsuji M,Mitsuyoshi Idoi
10.1016/s0887-8994(97)00187-2subject
Has Abstractpub_date
1998-03-01 00:00:00pages
275-7issue
3eissn
0887-8994issn
1873-5150pii
S0887899497001872journal_volume
18pub_type
杂志文章abstract::Cardiac arrhythmia may be one of the major causes of sudden unexpected death in children with epilepsy. We assessed drug-induced QT prolongation to establish whether the use of antiepileptic drugs contributes to sudden unexpected death. A total of 178 children with epilepsy (93 males and 85 females, with ages ranging ...
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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更新日期:1998-07-01 00:00:00
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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更新日期:2011-04-01 00:00:00
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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更新日期:2014-06-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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更新日期:2012-06-01 00:00:00
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