Issues with recruitment to randomised controlled trials in the drug and alcohol field: a literature review and Australian case study.

Abstract:

ISSUES:The randomised control trial (RCT) is a widely used tool for measuring the effectiveness of health treatments and services. However, subject recruitment is an ongoing challenge for those conducting RCTs and may have a serious impact on the success of the study and the reliability of the outcomes. APPROACH:In this review we present an examination of the problems and strategies associated with recruitment to RCTs, with particular reference to studies conducted in the drug and alcohol field. A case study of recruitment to an RCT for the treatment of alcohol dependence is presented, supplemented by PubMed, Current Contents and Medline searches to identify relevant publications. KEY FINDINGS:The literature suggests that the most common barriers to patient participation involve fears of assignment to placebo treatment, insufficient compensation and poor attendance at initial appointments. Moreover, subject referrals from staff may be a greater problem than reluctance of patients. Referrals are inhibited by complicated entry criteria, time constraints due to busy work schedules or a limited research culture. IMPLICATIONS:Subject recruitment may be promoted by financial reimbursement, close partnerships between research and referral staff; increasing the treatment group ratio in multi-drug trials to minimise randomisation to placebo; addressing negative staff attitudes; and simplifying the referral process. CONCLUSION:The need for multi-centre sites in Australian drug and alcohol treatment studies is highlighted.

journal_name

Drug Alcohol Rev

journal_title

Drug and alcohol review

authors

Thomson CL,Morley KC,Teesson M,Sannibale C,Haber PS

doi

10.1080/09595230701829561

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

115-22

issue

2

eissn

0959-5236

issn

1465-3362

pii

790496786

journal_volume

27

pub_type

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