Abstract:
ISSUES:The randomised control trial (RCT) is a widely used tool for measuring the effectiveness of health treatments and services. However, subject recruitment is an ongoing challenge for those conducting RCTs and may have a serious impact on the success of the study and the reliability of the outcomes. APPROACH:In this review we present an examination of the problems and strategies associated with recruitment to RCTs, with particular reference to studies conducted in the drug and alcohol field. A case study of recruitment to an RCT for the treatment of alcohol dependence is presented, supplemented by PubMed, Current Contents and Medline searches to identify relevant publications. KEY FINDINGS:The literature suggests that the most common barriers to patient participation involve fears of assignment to placebo treatment, insufficient compensation and poor attendance at initial appointments. Moreover, subject referrals from staff may be a greater problem than reluctance of patients. Referrals are inhibited by complicated entry criteria, time constraints due to busy work schedules or a limited research culture. IMPLICATIONS:Subject recruitment may be promoted by financial reimbursement, close partnerships between research and referral staff; increasing the treatment group ratio in multi-drug trials to minimise randomisation to placebo; addressing negative staff attitudes; and simplifying the referral process. CONCLUSION:The need for multi-centre sites in Australian drug and alcohol treatment studies is highlighted.
journal_name
Drug Alcohol Revjournal_title
Drug and alcohol reviewauthors
Thomson CL,Morley KC,Teesson M,Sannibale C,Haber PSdoi
10.1080/09595230701829561subject
Has Abstractpub_date
2008-03-01 00:00:00pages
115-22issue
2eissn
0959-5236issn
1465-3362pii
790496786journal_volume
27pub_type
杂志文章,评审abstract:INTRODUCTION AND AIMS:Drug induced QT prolongation occurs in patients with substance use disorders from prescription medications that prolong the QT, such as methadone. Knowing the prevalence of QT prolongation in this population is important for prescribers. This study aimed to investigate the prevalence of QT prolong...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12415
更新日期:2017-03-01 00:00:00
abstract::Patient-centred tobacco management approaches tobacco smoking as a chronic disease and can be offered to all smokers irrespective of their attitude to quitting. Maintaining a long-term relationship with smokers enables the adoption of flexible solutions and shared goals. It is argued that patient-centred tobacco manag...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12082
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:The province of Saskatchewan, Canada introduced minimum prices graded by alcohol strength in April 2010. As previous research found this intervention significantly decreased alcohol consumption and alcohol-attributable morbidity, we aim to test the association between the intervention and the rate...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12670
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION AND AIMS:Cannabis use rates in Australia have declined since 2001. No research to date has examined possible reasons, despite evident policy interest in understanding such a positive public health outcome. In a 'first pass' examination, five possible reasons are explored: (i) attitudinal shifts regarding t...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12553
更新日期:2017-09-01 00:00:00
abstract::We outline and evaluate competing explanations of three relationships that have consistently been found between cannabis use and the use of other illicit drugs, namely, (1) that cannabis use typically precedes the use of other illicit drugs; and that (2) the earlier cannabis is used, and (3) the more regularly it is u...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595230500126698
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:There is a concern that cannabis use is an important barrier to reducing Aboriginal and Torres Strait Islander smoking. We investigate the associations of cannabis use and tobacco smoking and quitting in two large national samples. DESIGN AND METHODS:The 2012-2013 National Aboriginal and Torres S...
journal_title:Drug and alcohol review
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doi:10.1111/dar.12609
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION AND AIMS:Emerging research suggests that the sub-population of anabolic-androgenic steroid (AAS) users who experience physical appearance concerns may suffer greater psychological dysfunction than other sub-populations, including users with athletic or occupational concerns. Thus, among current AAS users, ...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12688
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION AND AIMS:Online gambling advertising and user-generated gambling content have increased. This study used a social psychological online experiment to analyse young people's reactions towards and self-reported interests in social media gambling messages. DESIGN AND METHODS:A vignette experiment with a two-l...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.13010
更新日期:2020-02-01 00:00:00
abstract::As with other addictions, human alcoholism is characterised as a chronically relapsing condition. Consequently, the therapeutic goal is the development of clinically effective, safe drugs that promote high adherence rates and prevent relapse. These products can then be used in conjunction with psychosocial approaches....
journal_title:Drug and alcohol review
pub_type: 杂志文章,评审
doi:10.1080/09595230601036937
更新日期:2007-01-01 00:00:00
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journal_title:Drug and alcohol review
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doi:10.1111/dar.13019
更新日期:2020-03-01 00:00:00
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journal_title:Drug and alcohol review
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doi:10.1111/dar.12921
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION AND AIMS:Insight is a multi-dimensional construct that predicts treatment outcomes of people with mental illness. Research into insight in substance dependent populations is limited and measures of cognitive insight have not been validated for this population. DESIGN AND METHODS:A cross sectional survey w...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/dar.12966
更新日期:2019-09-01 00:00:00
abstract::The number of patients in hospitals who experience alcohol-related problems is high, and the provision of intervention for these patients is a significant public health measure. The current move towards casemix funding of acute hospital services provides an opportunity for the development of such programmes. Modificat...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239600186191
更新日期:1996-12-01 00:00:00
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journal_title:Drug and alcohol review
pub_type: 杂志文章,评审
doi:10.1111/dar.12877
更新日期:2019-01-01 00:00:00
abstract::Regular and systematic monitoring of drug markets provides the basis for evidence-based policy. In Australia, trends in ecstasy and related drug (ERD) markets have been monitored in selected jurisdictions since 2000 and nationally since 2003, by the Party Drugs Initiative (PDI). The PDI maximises the validity of concl...
journal_title:Drug and alcohol review
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239100185181
更新日期:1991-01-01 00:00:00
abstract::This presentation draws on recent New Zealand and international research to examine a number of questions about the possible public health impact of policy which allows alcohol to be advertised on the broadcast media. The relevant public health questions include: the contribution of alcohol advertising to aggregate le...
journal_title:Drug and alcohol review
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doi:10.1080/09595239500185541
更新日期:1995-01-01 00:00:00
abstract::This study investigated the characteristics associated with smoking during pregnancy. A total of 7836 pregnant women were surveyed between 1992 and 1999 in England. Of these 27% were smoking during pregnancy. Pregnant women were more likely to smoke if they were less educated, living in rented accommodation, in unskil...
journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595230220119291
更新日期:2002-03-01 00:00:00
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journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1080/09595239100185241
更新日期:1991-01-01 00:00:00
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journal_title:Drug and alcohol review
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journal_title:Drug and alcohol review
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doi:10.1080/09595230701829363
更新日期:2008-03-01 00:00:00
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journal_title:Drug and alcohol review
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更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Research has linked exposure to the drinking of one's partner or spouse and changes in alcohol-related behaviours. However, there is a dearth of studies which consider only cohabiting relationships. More couples are preferring to cohabit prior to and in place of marriage. As a result, studies focu...
journal_title:Drug and alcohol review
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Cognitive impairment is a common feature of individuals with substance-use disorders. However, research tends to exclude highly complex clinical cases, limiting the generalisability of findings for 'real-world' populations. The objective of this study was to examine the complexities associated wit...
journal_title:Drug and alcohol review
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Drug and alcohol review
pub_type: 杂志文章
doi:10.1111/j.1465-3362.2009.00050.x
更新日期:2009-07-01 00:00:00
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journal_title:Drug and alcohol review
pub_type: 杂志文章,评审
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更新日期:2021-01-24 00:00:00
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journal_title:Drug and alcohol review
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doi:10.1111/dar.12260
更新日期:2015-11-01 00:00:00
abstract::The range of tobacco control activities should be viewed as essential parts of a complex multi-component puzzle. Intervention strategies designed to address tobacco control should be comprehensive and include both primary and secondary prevention activities and be multi-faceted and capable of bringing about change at ...
journal_title:Drug and alcohol review
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION AND AIMS:Alcohol use has consistently been associated with smoking among nondaily smokers. However, this may not be an inevitable relationship that extends across all drinking sessions and/or all nondaily smokers. Recently, distinct subgroups of nondaily smokers have been identified, with one subgroup main...
journal_title:Drug and alcohol review
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00