Ventilator-associated pneumonia: impact of organisms on clinical resolution and medical resources utilization.

Abstract:

BACKGROUND:Clinical resolution of ventilator-associated pneumonia (VAP) determines the duration of treatment and mechanical ventilation. The aim of this study was to evaluate the influence of organisms and their susceptibility to treatment on outcomes. METHODS:Prospective observational study in three teaching ICUs. Sixty episodes of VAP with appropriate therapy (Haemophilus influenzae, 15 episodes; methicillin-sensitive Staphylococcus aureus [MSSA], 15 episodes; Pseudomonas aeruginosa, 15 episodes; and methicillin-resistant S aureus [MRSA], 15 episodes), and 30 episodes with initial inappropriate therapy, all due to P aeruginosa, were compared. The main outcome measures were clinical resolution variables and, in survivors, length of mechanical ventilation after VAP onset. RESULTS:A significant delay in the resolution of hypoxemia was observed in VAP episodes due to MRSA and P aeruginosa with inappropriate antibiotic therapy (IAT) (median time to resolution, 10 and 8 days, respectively) when compared with the remaining pathogens (median time to resolution, 2 days). A multiple regression model, adjusted for disease severity, confirmed the delayed clinical resolution for MRSA and P aeruginosa with IAT. Similar associations were documented for defervescence. Among survivors, the median duration of mechanical ventilation after VAP onset was significantly longer for MRSA (17 days) and P aeruginosa IAT (11 days) when compared with episodes due to H influenzae or MSSA (6 days). Multiple regression analysis, adjusted for disease severity, confirmed that MRSA required significantly (R(2) = 0.132; p < 0.01) longer respiratory support than other organisms. CONCLUSIONS:When treated promptly, the resolution of VAP due to MSSA, H influenzae, and P aeruginosa was comparable. The resolution of MRSA VAP, regardless of the appropriateness of initial antibiotic therapy, was associated with longer respiratory support.

journal_name

Chest

journal_title

Chest

authors

Vidaur L,Planas K,Sierra R,Dimopoulos G,Ramirez A,Lisboa T,Rello J

doi

10.1378/chest.07-2020

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

625-32

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)51319-6

journal_volume

133

pub_type

杂志文章

相关文献

CHEST文献大全
  • What is hypopnea, anyway?

    abstract::Quantitation of apneas and hypopneas is routinely included in studies of epidemiology, diagnosis, and treatment of sleep-disordered breathing (SDB). The definition of apnea appears clear-cut in the sleep literature. In contrast, the literature contains remarkable variety in both recording techniques and definitions of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.2.426

    authors: Moser NJ,Phillips BA,Berry DT,Harbison L

    更新日期:1994-02-01 00:00:00

  • Closure of a ventricular septal defect through the aortic valve: a note of caution regarding resultant narrowing of the aortic valve annulus.

    abstract::Closure of ventricular septal defects through the aortic valve annulus has been described for a variety of cardiac anomalies. This technique is most appropriate when simultaneous aortic valve replacement is anticipated. A continuous suture through the patch material may produce a purse-string effect upon the aortic va...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.2.311

    authors: Stewart S

    更新日期:1976-08-01 00:00:00

  • Mediastinal lymphadenopathy in patients undergoing cardiac transplant evaluation.

    abstract:BACKGROUND:We evaluated the association between hemodynamic parameters of chronic congestive heart failure (CHF) and mediastinal lymphadenopathy (MLA) in heart transplantation (HT) candidates and the effect of HT on MLA. We also described the results of lymph node (LN) biopsies of MLA in the patients. METHODS:Patients...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-1386

    authors: Pastis NJ Jr,Van Bakel AB,Brand TM,Ravenel JG,Gilbert GE,Silvestri GA,Judson MA

    更新日期:2011-06-01 00:00:00

  • Septic pulmonary embolism: presenting features and clinical course of 14 patients.

    abstract:BACKGROUND:Septic pulmonary embolism (SPE) is an uncommon disorder with an insidious onset and is difficult to diagnose. STUDY OBJECTIVES:To characterize the presenting features and clinical course of patients with SPE. DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Fourteen su...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.1.162

    authors: Cook RJ,Ashton RW,Aughenbaugh GL,Ryu JH

    更新日期:2005-07-01 00:00:00

  • Reversal of central sleep apnea using nasal CPAP.

    abstract::Based on the theory that obstructive (OSA) and central (CSA) sleep apneas share common pathophysiologic mechanisms, we attempted to treat eight patients with predominantly CSA by continuous positive airway pressure (CPAP). All patients exhibited repetitive episodes of CSA and mixed sleep apneas (MSA) in the supine pos...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.2.165

    authors: Issa FG,Sullivan CE

    更新日期:1986-08-01 00:00:00

  • Genetics of asthma and COPD. Similar results for different phenotypes.

    abstract::Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for b...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.126.2_suppl_1.105S

    authors: Meyers DA,Larj MJ,Lange L

    更新日期:2004-08-01 00:00:00

  • Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema.

    abstract:STUDY OBJECTIVES:To identify the relative contribution of hydrostatic and permeability mechanisms to the development of human neurogenic pulmonary edema. DESIGN:Retrospective review of patients with neurogenic pulmonary edema who had pulmonary edema fluid analysis. SETTING:University hospital ICU. PATIENTS:Twelve pa...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.5.1326

    authors: Smith WS,Matthay MA

    更新日期:1997-05-01 00:00:00

  • Long-term outcome for obstructive sleep apnea syndrome patients. Mortality.

    abstract::As the actual mortality and morbidity of obstructive sleep apnea syndrome (OSAS) have been unknown heretofore, we undertook a follow-up study of 198 OSAS patients seen at the Stanford Sleep Disorders Clinic between 1972 and 1980, for whom either tracheostomy (71 patients) or weight loss (127 patients) had been recomme...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.6.1200

    authors: Partinen M,Jamieson A,Guilleminault C

    更新日期:1988-12-01 00:00:00

  • Limited short-term steroid responsiveness is associated with thickening of bronchial basement membrane in severe asthma.

    abstract:BACKGROUND:The clinical manifestations of bronchial remodeling in asthma and the potential impact of this process on lung function remain unclear. We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-0232

    authors: Bourdin A,Kleis S,Chakra M,Vachier I,Paganin F,Godard P,Chanez P

    更新日期:2012-06-01 00:00:00

  • Periodic leg movement, nasal CPAP, and expiratory muscles.

    abstract:BACKGROUND:Periodic leg movements (PLMs) may appear during nasal CPAP titration, persisting despite the elimination of hypopneas. METHODS:Systematic recordings of expiratory abdominal muscles on the right and left sides with surface electromyographic (EMG) electrodes lateral to navel, and close from the lateral side o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-1563

    authors: Seo WH,Guilleminault C

    更新日期:2012-07-01 00:00:00

  • Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

    abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...

    journal_title:Chest

    pub_type: 指南,杂志文章,实务指引,评审

    doi:10.1378/chest.126.3_suppl.429S

    authors: Singer DE,Albers GW,Dalen JE,Go AS,Halperin JL,Manning WJ

    更新日期:2004-09-01 00:00:00

  • How Common Is Airflow Limitation in Patients With Emphysema on CT Scan of the Chest?

    abstract:BACKGROUND:COPD has traditionally been defined by the presence of irreversible airflow limitation on spirometry using either the GOLD (Global Initiative for Chronic Obstructive Lung Disease) or American Thoracic Society/European Respiratory Society criteria (lower limit of normal [LLN]). We have observed that some pati...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-1556

    authors: Lutchmedial SM,Creed WG,Moore AJ,Walsh RR,Gentchos GE,Kaminsky DA

    更新日期:2015-07-01 00:00:00

  • Early detection of COPD in a high-risk population using spirometric screening.

    abstract:STUDY OBJECTIVES:To evaluate the efficacy of mass spirometry use for the detection of airflow obstruction in a high-risk population. DESIGN:Free spirometry was offered to smokers who were > 39 years of age with a smoking history of > 10 pack-years. Action was preceded by the dissemination of information on the causes ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.3.731

    authors: Zieliñski J,Bednarek M,Know the Age of Your Lung Study Group.

    更新日期:2001-03-01 00:00:00

  • Intensive Monitoring of Urine Output Is Associated With Increased Detection of Acute Kidney Injury and Improved Outcomes.

    abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2017.05.011

    authors: Jin K,Murugan R,Sileanu FE,Foldes E,Priyanka P,Clermont G,Kellum JA

    更新日期:2017-11-01 00:00:00

  • Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy.

    abstract::Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiolog...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.127.4.1312

    authors: Busse W,Kraft M

    更新日期:2005-04-01 00:00:00

  • A 26-Year-Old Woman With a Small Right Lung and a Right-Sided Heart.

    abstract::A 26-year-old woman presented with abnormal findings on a chest radiograph. She had no significant history other than a fever 4 months prior to presentation that had resolved without a definite cause identified. She denied cough, shortness of breath, chest pain, history of smoking, environmental exposures, or prior pr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2015.08.023

    authors: Albores J,Smith MI

    更新日期:2016-03-01 00:00:00

  • An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function.

    abstract:STUDY OBJECTIVES:Preoperative renal dysfunction is a risk factor for adverse events in cardiac surgery. This study compared creatinine clearance (ClCr), estimated from the Cockroft and Gault formula, and plasma creatinine level as predictors of outcome after cardiac surgery. DESIGN:Prospective, observational. SETTING...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.5.1852

    authors: Wang F,Dupuis JY,Nathan H,Williams K

    更新日期:2003-11-01 00:00:00

  • A 78-Year-Old Man With Repeated Dyspnea and Neutrophilia in Peripheral Blood and BAL.

    abstract:CASE PRESENTATION:A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.07.034

    authors: Nakamatsu E,Morita T,Morishima A,Tagawa H,Furukawa M,Matsushita M,Yamane H

    更新日期:2020-01-01 00:00:00

  • Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension.

    abstract:STUDY OBJECTIVES:Cellular growth in the vascular wall, including endothelial and smooth-muscle cell proliferation, is recognized as a component of the obstructive vasculopathy observed in the small vessels of the lungs in pulmonary arterial hypertension (PAH). We hypothesized that angiogenic growth factors may have a r...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.126.4.1255

    authors: Benisty JI,McLaughlin VV,Landzberg MJ,Rich JD,Newburger JW,Rich S,Folkman J

    更新日期:2004-10-01 00:00:00

  • Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS.

    abstract:BACKGROUND:Direct (pulmonary) and indirect (extrapulmonary) ARDS are distinct syndromes with important pathophysiologic differences. The goal of this study was to determine whether clinical characteristics and predictors of mortality differ between direct or indirect ARDS. METHODS:This retrospective observational coho...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.09.004

    authors: Luo L,Shaver CM,Zhao Z,Koyama T,Calfee CS,Bastarache JA,Ware LB

    更新日期:2017-04-01 00:00:00

  • Pulmonary hypertension in patients with idiopathic pulmonary fibrosis.

    abstract:STUDY OBJECTIVES:To determine the impact on survival and clinical correlates of pulmonary hypertension (PH) occurring in patients with idiopathic pulmonary fibrosis (IPF). DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Among 487 consecutive patients with IPF, we identified 136 p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.4.2393

    authors: Nadrous HF,Pellikka PA,Krowka MJ,Swanson KL,Chaowalit N,Decker PA,Ryu JH

    更新日期:2005-10-01 00:00:00

  • Effect of weight reduction on respiratory function and airway reactivity in obese women.

    abstract:BACKGROUND:Population-based studies have documented an association between obesity and an increased prevalence of asthma in women. METHODS:We prospectively studied 58 obese women with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine wh...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.6.2046

    authors: Aaron SD,Fergusson D,Dent R,Chen Y,Vandemheen KL,Dales RE

    更新日期:2004-06-01 00:00:00

  • Comparison of intravenous and inhaled terbutaline in the treatment of asthma.

    abstract::In a double-blind crossover controlled study, intravenous (IV) or nebulized terbutaline was given to eight patients with moderately severe asthma on two separate days. Four incremental doses of terbutaline were given by each route to establish a maximal effect. Both routes of administration produced significant increa...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.79.5.506

    authors: Pierce RJ,Payne CR,Williams SJ,Denison DM,Clark TJ

    更新日期:1981-05-01 00:00:00

  • Oxygen supplementation and cardiac-autonomic modulation in COPD.

    abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.118.3.691

    authors: Bartels MN,Gonzalez JM,Kim W,De Meersman RE

    更新日期:2000-09-01 00:00:00

  • Childhood obstructive sleep-disordered breathing: a clinical update and discussion of technological innovations and challenges.

    abstract::Childhood sleep-disordered breathing (SDB) has been known to be associated with health and cognitive impacts for more than a century, and yet our understanding of this disorder is in its infancy. Neuropsychological consequences in children with snoring or subtle breathing disturbances not meeting the traditional defin...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.06-2827

    authors: Halbower AC,Ishman SL,McGinley BM

    更新日期:2007-12-01 00:00:00

  • Bronchiolitis obliterans and Nocardia asteroides infection of the lung.

    abstract::This report describes a patient with right lower lung (RLL) pneumonia of a subacute nature. Sputum and bronchial washings both grew N asteroides. Open lung biopsy showed bronchiolitis obliterans. Both the clinical and radiologic picture dramatically improved during three weeks of treatment with trimethoprim and sulfam...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.6.1107

    authors: Camp M,Mehta JB,Whitson M

    更新日期:1987-12-01 00:00:00

  • Diuretics in obstructive sleep apnea with diastolic heart failure.

    abstract:BACKGROUND:Upper airway edema might contribute to pharyngeal collapsibility and account for the high prevalence of obstructive sleep apnea (OSA) in patients with heart disease. The aim of this study was to evaluate if intensive unloading with diuretics improves sleep-disordered breathing and increases pharyngeal calibe...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.07-0311

    authors: Bucca CB,Brussino L,Battisti A,Mutani R,Rolla G,Mangiardi L,Cicolin A

    更新日期:2007-08-01 00:00:00

  • Mitral valve replacement: a comparison of two prostheses.

    abstract::Between November, 1965 and June, 1970, 175 patients underwent mitral valve replacement with the Smeloff-Cutter prosthesis (109 patients) or the toroidal valve (66 patients). The early mortality for patients with a toroidal mitral prosthesis was 18.2 percent (12 patients) and the late mortality 34.8 percent (23 patient...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.2.135

    authors: Rees JR,Holswade GR,Carlson RG,Subramanian VA,Murphy TE,Lillehei CW

    更新日期:1977-02-01 00:00:00

  • Lipid mediator dysregulation in primary pulmonary hypertension.

    abstract::The characteristic arteriopathy of primary pulmonary hypertension (PPH) with attendant endothelial dysfunction provides an opportunity for enhanced cellular activation in the lung. Data from many laboratories support the concept of altered eicosanoid metabolism in PPH. Rigorously quantitative measurements of the excre...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.114.3_supplement.205s

    authors: Christman BW

    更新日期:1998-09-01 00:00:00

  • Monitoring carbon dioxide tension and arterial oxygen saturation by a single earlobe sensor in patients with critical illness or sleep apnea.

    abstract:OBJECTIVES:The purpose of the study was to evaluate a novel, combined sensor for transcutaneous monitoring of arterial oxygen saturation and carbon dioxide tension. DESIGN:The new monitoring technique was compared to established reference methods. SETTING:ICU and sleep laboratory of a university hospital. PATIENTS:E...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.3.1291

    authors: Senn O,Clarenbach CF,Kaplan V,Maggiorini M,Bloch KE

    更新日期:2005-09-01 00:00:00