Abstract:
BACKGROUND:Clinical resolution of ventilator-associated pneumonia (VAP) determines the duration of treatment and mechanical ventilation. The aim of this study was to evaluate the influence of organisms and their susceptibility to treatment on outcomes. METHODS:Prospective observational study in three teaching ICUs. Sixty episodes of VAP with appropriate therapy (Haemophilus influenzae, 15 episodes; methicillin-sensitive Staphylococcus aureus [MSSA], 15 episodes; Pseudomonas aeruginosa, 15 episodes; and methicillin-resistant S aureus [MRSA], 15 episodes), and 30 episodes with initial inappropriate therapy, all due to P aeruginosa, were compared. The main outcome measures were clinical resolution variables and, in survivors, length of mechanical ventilation after VAP onset. RESULTS:A significant delay in the resolution of hypoxemia was observed in VAP episodes due to MRSA and P aeruginosa with inappropriate antibiotic therapy (IAT) (median time to resolution, 10 and 8 days, respectively) when compared with the remaining pathogens (median time to resolution, 2 days). A multiple regression model, adjusted for disease severity, confirmed the delayed clinical resolution for MRSA and P aeruginosa with IAT. Similar associations were documented for defervescence. Among survivors, the median duration of mechanical ventilation after VAP onset was significantly longer for MRSA (17 days) and P aeruginosa IAT (11 days) when compared with episodes due to H influenzae or MSSA (6 days). Multiple regression analysis, adjusted for disease severity, confirmed that MRSA required significantly (R(2) = 0.132; p < 0.01) longer respiratory support than other organisms. CONCLUSIONS:When treated promptly, the resolution of VAP due to MSSA, H influenzae, and P aeruginosa was comparable. The resolution of MRSA VAP, regardless of the appropriateness of initial antibiotic therapy, was associated with longer respiratory support.
journal_name
Chestjournal_title
Chestauthors
Vidaur L,Planas K,Sierra R,Dimopoulos G,Ramirez A,Lisboa T,Rello Jdoi
10.1378/chest.07-2020subject
Has Abstractpub_date
2008-03-01 00:00:00pages
625-32issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(15)51319-6journal_volume
133pub_type
杂志文章相关文献
CHEST文献大全abstract::Quantitation of apneas and hypopneas is routinely included in studies of epidemiology, diagnosis, and treatment of sleep-disordered breathing (SDB). The definition of apnea appears clear-cut in the sleep literature. In contrast, the literature contains remarkable variety in both recording techniques and definitions of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.2.426
更新日期:1994-02-01 00:00:00
abstract::Closure of ventricular septal defects through the aortic valve annulus has been described for a variety of cardiac anomalies. This technique is most appropriate when simultaneous aortic valve replacement is anticipated. A continuous suture through the patch material may produce a purse-string effect upon the aortic va...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.70.2.311
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:We evaluated the association between hemodynamic parameters of chronic congestive heart failure (CHF) and mediastinal lymphadenopathy (MLA) in heart transplantation (HT) candidates and the effect of HT on MLA. We also described the results of lymph node (LN) biopsies of MLA in the patients. METHODS:Patients...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1386
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Septic pulmonary embolism (SPE) is an uncommon disorder with an insidious onset and is difficult to diagnose. STUDY OBJECTIVES:To characterize the presenting features and clinical course of patients with SPE. DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Fourteen su...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.1.162
更新日期:2005-07-01 00:00:00
abstract::Based on the theory that obstructive (OSA) and central (CSA) sleep apneas share common pathophysiologic mechanisms, we attempted to treat eight patients with predominantly CSA by continuous positive airway pressure (CPAP). All patients exhibited repetitive episodes of CSA and mixed sleep apneas (MSA) in the supine pos...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.2.165
更新日期:1986-08-01 00:00:00
abstract::Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for b...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.126.2_suppl_1.105S
更新日期:2004-08-01 00:00:00
abstract:STUDY OBJECTIVES:To identify the relative contribution of hydrostatic and permeability mechanisms to the development of human neurogenic pulmonary edema. DESIGN:Retrospective review of patients with neurogenic pulmonary edema who had pulmonary edema fluid analysis. SETTING:University hospital ICU. PATIENTS:Twelve pa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.5.1326
更新日期:1997-05-01 00:00:00
abstract::As the actual mortality and morbidity of obstructive sleep apnea syndrome (OSAS) have been unknown heretofore, we undertook a follow-up study of 198 OSAS patients seen at the Stanford Sleep Disorders Clinic between 1972 and 1980, for whom either tracheostomy (71 patients) or weight loss (127 patients) had been recomme...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.6.1200
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:The clinical manifestations of bronchial remodeling in asthma and the potential impact of this process on lung function remain unclear. We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0232
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Periodic leg movements (PLMs) may appear during nasal CPAP titration, persisting despite the elimination of hypopneas. METHODS:Systematic recordings of expiratory abdominal muscles on the right and left sides with surface electromyographic (EMG) electrodes lateral to navel, and close from the lateral side o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-1563
更新日期:2012-07-01 00:00:00
abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...
journal_title:Chest
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1378/chest.126.3_suppl.429S
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:COPD has traditionally been defined by the presence of irreversible airflow limitation on spirometry using either the GOLD (Global Initiative for Chronic Obstructive Lung Disease) or American Thoracic Society/European Respiratory Society criteria (lower limit of normal [LLN]). We have observed that some pati...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-1556
更新日期:2015-07-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the efficacy of mass spirometry use for the detection of airflow obstruction in a high-risk population. DESIGN:Free spirometry was offered to smokers who were > 39 years of age with a smoking history of > 10 pack-years. Action was preceded by the dissemination of information on the causes ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.3.731
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.05.011
更新日期:2017-11-01 00:00:00
abstract::Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiolog...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.127.4.1312
更新日期:2005-04-01 00:00:00
abstract::A 26-year-old woman presented with abnormal findings on a chest radiograph. She had no significant history other than a fever 4 months prior to presentation that had resolved without a definite cause identified. She denied cough, shortness of breath, chest pain, history of smoking, environmental exposures, or prior pr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2015.08.023
更新日期:2016-03-01 00:00:00
abstract:STUDY OBJECTIVES:Preoperative renal dysfunction is a risk factor for adverse events in cardiac surgery. This study compared creatinine clearance (ClCr), estimated from the Cockroft and Gault formula, and plasma creatinine level as predictors of outcome after cardiac surgery. DESIGN:Prospective, observational. SETTING...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.5.1852
更新日期:2003-11-01 00:00:00
abstract:CASE PRESENTATION:A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.07.034
更新日期:2020-01-01 00:00:00
abstract:STUDY OBJECTIVES:Cellular growth in the vascular wall, including endothelial and smooth-muscle cell proliferation, is recognized as a component of the obstructive vasculopathy observed in the small vessels of the lungs in pulmonary arterial hypertension (PAH). We hypothesized that angiogenic growth factors may have a r...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.126.4.1255
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Direct (pulmonary) and indirect (extrapulmonary) ARDS are distinct syndromes with important pathophysiologic differences. The goal of this study was to determine whether clinical characteristics and predictors of mortality differ between direct or indirect ARDS. METHODS:This retrospective observational coho...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.09.004
更新日期:2017-04-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the impact on survival and clinical correlates of pulmonary hypertension (PH) occurring in patients with idiopathic pulmonary fibrosis (IPF). DESIGN:Retrospective study. SETTING:Tertiary care, referral medical center. PATIENTS:Among 487 consecutive patients with IPF, we identified 136 p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2393
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Population-based studies have documented an association between obesity and an increased prevalence of asthma in women. METHODS:We prospectively studied 58 obese women with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine wh...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.125.6.2046
更新日期:2004-06-01 00:00:00
abstract::In a double-blind crossover controlled study, intravenous (IV) or nebulized terbutaline was given to eight patients with moderately severe asthma on two separate days. Four incremental doses of terbutaline were given by each route to establish a maximal effect. Both routes of administration produced significant increa...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.79.5.506
更新日期:1981-05-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.118.3.691
更新日期:2000-09-01 00:00:00
abstract::Childhood sleep-disordered breathing (SDB) has been known to be associated with health and cognitive impacts for more than a century, and yet our understanding of this disorder is in its infancy. Neuropsychological consequences in children with snoring or subtle breathing disturbances not meeting the traditional defin...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.06-2827
更新日期:2007-12-01 00:00:00
abstract::This report describes a patient with right lower lung (RLL) pneumonia of a subacute nature. Sputum and bronchial washings both grew N asteroides. Open lung biopsy showed bronchiolitis obliterans. Both the clinical and radiologic picture dramatically improved during three weeks of treatment with trimethoprim and sulfam...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.6.1107
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Upper airway edema might contribute to pharyngeal collapsibility and account for the high prevalence of obstructive sleep apnea (OSA) in patients with heart disease. The aim of this study was to evaluate if intensive unloading with diuretics improves sleep-disordered breathing and increases pharyngeal calibe...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-0311
更新日期:2007-08-01 00:00:00
abstract::Between November, 1965 and June, 1970, 175 patients underwent mitral valve replacement with the Smeloff-Cutter prosthesis (109 patients) or the toroidal valve (66 patients). The early mortality for patients with a toroidal mitral prosthesis was 18.2 percent (12 patients) and the late mortality 34.8 percent (23 patient...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.2.135
更新日期:1977-02-01 00:00:00
abstract::The characteristic arteriopathy of primary pulmonary hypertension (PPH) with attendant endothelial dysfunction provides an opportunity for enhanced cellular activation in the lung. Data from many laboratories support the concept of altered eicosanoid metabolism in PPH. Rigorously quantitative measurements of the excre...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.114.3_supplement.205s
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:The purpose of the study was to evaluate a novel, combined sensor for transcutaneous monitoring of arterial oxygen saturation and carbon dioxide tension. DESIGN:The new monitoring technique was compared to established reference methods. SETTING:ICU and sleep laboratory of a university hospital. PATIENTS:E...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1291
更新日期:2005-09-01 00:00:00