Abstract:
BACKGROUND:Population-based studies have documented an association between obesity and an increased prevalence of asthma in women. METHODS:We prospectively studied 58 obese women with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine whether loss of body mass would be correlated with improvements in bronchial reactivity, lung function, and disease-specific health status. RESULTS:Patients lost an average of 20 kg over the 6-month period. For every 10% relative loss of weight, the FVC improved by 92 mL (p = 0.05) and the FEV(1) improved by 73 mL (p = 0.04), however, bronchial reactivity did not significantly change with weight loss (p = 0.23). Patients who lost > 13% of their pretreatment weight experienced improvements in FEV(1) (p = 0.01), FVC (p = 0.02), and total lung capacity (p = 0.05) compared to patients in the lowest quartile who failed to lose significant amounts of weight. Neither group experienced any significant change in methacholine responsiveness (p = 0.57). Patients who completed the 6-month weight loss program experienced improvements in respiratory health status, irrespective of weight loss. CONCLUSION:We concluded that weight loss can improve lung function in obese women, however, the improvements appear to be independent of changes in airway reactivity.
journal_name
Chestjournal_title
Chestauthors
Aaron SD,Fergusson D,Dent R,Chen Y,Vandemheen KL,Dales REdoi
10.1378/chest.125.6.2046subject
Has Abstractpub_date
2004-06-01 00:00:00pages
2046-52issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(16)58974-0journal_volume
125pub_type
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