Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy.


:Humoral and cell-mediated immunity (CMI) against B. pertussis was assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99.1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [> or = 2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6.2% samples recorded titres > or = 100 EU/ml. CMI was positive [stimulation index (SI) > or = 5] against PT in 39.0% of all samples. This study suggests that B. pertussis continues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pertussis boosters may be of value in these populations. Nevertheless, over the last 10 years, large increases in vaccination coverage rates have contributed to reduce the spread of the aetiological agent, especially in the immunized population.


Epidemiol Infect


Gabutti G,Bergamini M,Bonanni P,Guido M,Fenoglio D,Giammanco A,Sindoni L,Zotti C,Boddi V,Bamfi F,Severini R,Bechini A,Boccalini S,Crovari P,Collaborative Group for the Study of Pertussis.




Has Abstract


2008-11-01 00:00:00














  • Streptococcus pyogenes vulvovaginitis in children in Nottingham.

    abstract::Isolates of Streptococcus pyogenes from vaginal swabs of children with vulvovaginitis received at Nottingham Public Health Laboratory during 1986-9 were studied. A total of 159 isolates was made during the 4 years, increasing from 17 in 1986 to 64 in 1989 and accounting for 11% of all vaginal swabs received from child...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Donald FE,Slack RC,Colman G

    更新日期:1991-06-01 00:00:00

  • Restriction fragment length polymorphisms among the flagellar genes of the Lior heat-labile serogroup reference strains and field strains of Campylobacter jejuni and C. coli.

    abstract::Several typing systems have been described for Campylobacter jejuni and C. coli, to assess the complex epidemiology of these important enteric pathogens. In the present study two typing methods, slide agglutination according to the Lior scheme, and the demonstration of restriction-fragment length polymorphisms (RFLP) ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Burnens AP,Wagner J,Lior H,Nicolet J,Frey J

    更新日期:1995-06-01 00:00:00

  • Daily shedding dynamics of E. coli O157 in an Australian grass-fed beef herd.

    abstract::This study aimed to describe the diurnal shedding dynamics of Escherichia coli O157 in cattle managed on pasture. The purpose was to identify the value of a single measurement for predicting the shedding status on subsequent days. Over a 14-day period, 24 beef cows with known E. coli O157 shedding status were sampled ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Lammers GA,Jordan D,McCONNEL CS,Heller J

    更新日期:2016-10-01 00:00:00

  • Transmission dynamics of lumpy skin disease in Ethiopia.

    abstract::Lumpy skin disease (LSD) is a severe disease of cattle caused by a Capripoxvirus and often caused epidemics in Ethiopia and many other countries. This study was undertaken to quantify the transmission between animals and to estimate the infection reproduction ratio in a predominantly mixed crop-livestock system and in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Molla W,Frankena K,DE Jong MCM

    更新日期:2017-10-01 00:00:00

  • Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations.

    abstract::This study compares the frequency and severity of influenza A/H1N1pdm09 (A/H1), influenza A/H3N2 (A/H3) and other respiratory virus infections in hospitalised patients. Data from 17 332 adult hospitalised patients admitted to Sir Charles Gairdner Hospital, Perth, Western Australia, with a respiratory illness between 2...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Minney-Smith CA,Selvey LA,Levy A,Smith DW

    更新日期:2019-11-28 00:00:00

  • Association between meteorological factors and reported cases of hand, foot, and mouth disease from 2000 to 2015 in Japan.

    abstract::The purpose of this study was to clarify the association between hand, foot, and mouth disease (HFMD) epidemics and meteorological conditions. We used HFMD surveillance data of all 47 prefectures in Japan from January 2000 to December 2015. Spectral analysis was performed using the maximum entropy method (MEM) for tem...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Sumi A,Toyoda S,Kanou K,Fujimoto T,Mise K,Kohei Y,Koyama A,Kobayashi N

    更新日期:2017-10-01 00:00:00

  • Incidence of childhood pneumonia and serotype and sequence-type distribution in Streptococcus pneumoniae isolates in Japan.

    abstract::The 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Tanaka J,Ishiwada N,Wada A,Chang B,Hishiki H,Kurosaki T,Kohno Y

    更新日期:2012-06-01 00:00:00

  • Social contacts of school children and the transmission of respiratory-spread pathogens.

    abstract::Empirical data about contact frequencies of children is needed for estimating parameters in mathematical modelling studies that investigate the effect of targeting influenza intervention to children. A survey about the social contacts of school children was conducted in a primary school in Germany. The distribution of...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Mikolajczyk RT,Akmatov MK,Rastin S,Kretzschmar M

    更新日期:2008-06-01 00:00:00

  • Bartonella infection in urban and rural dogs from the tropics: Brazil, Colombia, Sri Lanka and Vietnam.

    abstract::Dogs can be infected by a wide range of Bartonella spp., but limited studies have been conducted in tropical urban and rural dog populations. We aimed to determine Bartonella antibody prevalence in 455 domestic dogs from four tropical countries and detect Bartonella DNA in a subset of these dogs. Bartonella antibodies...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Brenner EC,Chomel BB,Singhasivanon OU,Namekata DY,Kasten RW,Kass PH,Cortés-Vecino JA,Gennari SM,Rajapakse RP,Huong LT,Dubey JP

    更新日期:2013-01-01 00:00:00

  • 2013 multistate outbreaks of Cyclospora cayetanensis infections associated with fresh produce: focus on the Texas investigations.

    abstract::The 2013 multistate outbreaks contributed to the largest annual number of reported US cases of cyclosporiasis since 1997. In this paper we focus on investigations in Texas. We defined an outbreak-associated case as laboratory-confirmed cyclosporiasis in a person with illness onset between 1 June and 31 August 2013, wi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Abanyie F,Harvey RR,Harris JR,Wiegand RE,Gaul L,Desvignes-Kendrick M,Irvin K,Williams I,Hall RL,Herwaldt B,Gray EB,Qvarnstrom Y,Wise ME,Cantu V,Cantey PT,Bosch S,DA Silva AJ,Fields A,Bishop H,Wellman A,Beal J,Wi

    更新日期:2015-12-01 00:00:00

  • Gastroenteritis associated with accidental contamination of drinking water with partially treated water.

    abstract::Due to human error, drinking water supplied to a new housing estate in The Netherlands was contaminated with grey water. The cohort of 921 accidentally exposed households (area A) had a higher attack rate for diarrhoea (54.1%) than a non-exposed cohort of 1529 households from an adjacent area (B) (24%) (RR 2.3, 95% CI...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Fernandes TM,Schout C,De Roda Husman AM,Eilander A,Vennema H,van Duynhoven YT

    更新日期:2007-07-01 00:00:00

  • The prevalence of antibodies to hepatitis A virus and its determinants in The Netherlands: a population-based survey.

    abstract::The prevalence of antibodies to hepatitis A virus was assessed in a Dutch nationwide sample (n = 7367). A questionnaire was used to study the association with various sociodemographic characteristics. Overall, 33.8% (95% CI 31.6-36%) of the population had hepatitis A antibodies. The seroprevalence was less than 10% in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Termorshuizen F,Dorigo-Zetsma JW,de Melker HE,van den Hof S,Conyn-Van Spaendonck MA

    更新日期:2000-06-01 00:00:00

  • Antigenic analysis of SAT 2 serotype foot-and-mouth disease virus isolates from Zimbabwe using monoclonal antibodies.

    abstract::This paper compares strains of foot-and-mouth disease (FMD) serotype SAT (South African Territories) 2 viruses isolated from Zimbabwe and other African countries using monoclonal antibodies (MAb). A sandwich-ELISA was used to examine the relative binding of anti-SAT 2 MAb to the various viruses. The MAb-binding profil...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Davidson FL,Crowther JR,Nqindi J,Knowles NJ,Thevasagayam SJ,Van Vuuren CJ

    更新日期:1995-08-01 00:00:00

  • Emergence of MRSA clone ST22 in healthy young adults in the community in the absence of risk factors.

    abstract::One thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA iso...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Mollaghan AM,Lucey B,Coffey A,Cotter L

    更新日期:2010-05-01 00:00:00

  • Applying the zero-inflated Poisson model with random effects to detect abnormal rises in school absenteeism indicating infectious diseases outbreak.

    abstract::Records of absenteeism from primary schools are valuable data for infectious diseases surveillance. However, the analysis of the absenteeism is complicated by the data features of clustering at zero, non-independence and overdispersion. This study aimed to generate an appropriate model to handle the absenteeism data c...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Song XX,Zhao Q,Tao T,Zhou CM,Diwan VK,Xu B

    更新日期:2018-09-01 00:00:00

  • Age-specific mixing generates transient outbreak risk following critical-level vaccination.

    abstract::Measles elimination goals have been adopted in a range of countries, sub-regions, and regions since the WHO declared an elimination goal by 2015 or 2020. All countries attempt to achieve and maintain high coverage through routine immunization programmes. This routine strategy, however, does not ensure the elimination ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Bhattacharyya S,Ferrari MJ

    更新日期:2017-01-01 00:00:00

  • Outbreaks of Escherichia coli O157 infections at multiple county agricultural fairs: a hazard of mixing cattle, concession stands and children.

    abstract::Escherichia coli O157 infections cause an estimated 60 deaths and 73 000 illnesses annually in the United States. A marked summer peak in incidence is largely unexplained. We investigated an outbreak of E. coli O157 infections at an agricultural fair in Ohio and implicated consumption of beverages made with fairground...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Crump JA,Braden CR,Dey ME,Hoekstra RM,Rickelman-Apisa JM,Baldwin DA,De Fijter SJ,Nowicki SF,Koch EM,Bannerman TL,Smith FW,Sarisky JP,Hochberg N,Mead PS

    更新日期:2003-12-01 00:00:00

  • Disease outbreaks associated with untreated recreational water use.

    abstract::Annual overviews of waterborne disease outbreaks associated with untreated recreational water use provided by authorities responsible for bathing-water quality and public health in The Netherlands revealed 742 outbreaks during 1991-2007 mainly comprising of skin conditions (48%) and gastroenteritis (31%) and involving...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Schets FM,De Roda Husman AM,Havelaar AH

    更新日期:2011-07-01 00:00:00

  • A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents.

    abstract::Cowpox is an orthopoxvirus infection endemic in European wild rodents, but with a wide host range including human beings. In this longitudinal study we examined cowpox in two wild rodent species, bank voles Clethrionomys glareolus and wood mice Apodemus sylvaticus, to investigate the dynamics of a virus in its wild re...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Hazel SM,Bennett M,Chantrey J,Bown K,Cavanagh R,Jones TR,Baxby D,Begon M

    更新日期:2000-06-01 00:00:00

  • Emerging zoonoses and vector-borne infections affecting humans in Europe.

    abstract::The purpose of this study was to assess and describe the current spectrum of emerging zoonoses between 2000 and 2006 in European countries. A computerized search of the Medline database from January 1966 to August 2006 for all zoonotic agents in European countries was performed using specific criteria for emergence. F...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,评审


    authors: Vorou RM,Papavassiliou VG,Tsiodras S

    更新日期:2007-11-01 00:00:00

  • Effectiveness of environmental decontamination as an infection control measure.

    abstract::The effectiveness of environmental decontamination (ED) as a measure in the control of infectious diseases is controversial. This work quantifies the effectiveness of ED by analysing the transmission of pathogens from the environment to susceptible hosts in a Susceptible-Infected-Susceptible model. Analysis of the mod...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Bani-Yaghoub M,Gautam R,Döpfer D,Kaspar CW,Ivanek R

    更新日期:2012-03-01 00:00:00

  • Quantitative risk assessment of the introduction of rabies into Japan through the importation of dogs and cats worldwide.

    abstract::Japan has been free from rabies since 1958. A strict import regimen has been adopted since 2004 consisting of identification of an animal with microchip, two-time rabies vaccination, neutralizing antibody titration test and a waiting period of 180 days. The present study aims to quantitatively assess the risk of rabie...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Kwan NC,Sugiura K,Hosoi Y,Yamada A,Snary EL

    更新日期:2017-04-01 00:00:00

  • Pseudomonas aeruginosa dose response and bathing water infection.

    abstract::Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Thre...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章,评审


    authors: Roser DJ,van den Akker B,Boase S,Haas CN,Ashbolt NJ,Rice SA

    更新日期:2014-03-01 00:00:00

  • Transmission of bovine herpesvirus 1 within and between herds on an island with a BHV1 control programme.

    abstract::Transmission of bovine herpesvirus 1 (BHV1) within and between herds was studied on the island of Ameland, The Netherlands. There were 50 herds with 3300 head of cattle on the island. Herds were divided into three groups: (1) only containing seronegative cattle, (2) containing seronegative cattle and vaccinated seropo...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Hage JJ,Schukken YH,Schols H,Maris-Veldhuis MA,Rijsewijk FA,Klaassen CH

    更新日期:2003-06-01 00:00:00

  • Estimating infectious diseases incidence: validity of capture-recapture analysis and truncated models for incomplete count data.

    abstract::Capture-recapture analysis has been used to evaluate infectious disease surveillance. Violation of the underlying assumptions can jeopardize the validity of the capture-recapture estimates and a tool is needed for cross-validation. We re-examined 19 datasets of log-linear model capture-recapture studies on infectious ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: van Hest NA,Grant AD,Smit F,Story A,Richardus JH

    更新日期:2008-01-01 00:00:00

  • Two sequential outbreaks in two villages illustrate the various modes of transmission of cholera.

    abstract::We investigated two sequential outbreaks of severe diarrhoea in two neighbouring villages of Orissa, in 2005. We conducted descriptive and matched case-control studies. The attack rates were 5.6% (n=62) and 5.2% (n=51), respectively, in the first and second villages. One death was reported in the second village (case ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: DAS A,Manickam P,Hutin Y,Pattanaik B,Pal BB,Chhotray GP,Kar SK,Gupte MD

    更新日期:2009-06-01 00:00:00

  • Putative household outbreaks of campylobacteriosis typically comprise single MLST genotypes.

    abstract::During a 15-month period in Scotland a small but important number of human Campylobacter cases (3·2%) arose from 91 putative household outbreaks. Of the 26 outbreaks with known strain composition, 89% were composed of the same MLST which supports the potential use of MLST in public health epidemiology. The number of c...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Rotariu O,Smith-Palmer A,Cowden J,Bessell PR,Innocent GT,Reid SW,Matthews L,Dallas J,Ogden ID,Forbes KJ,Strachan NJ

    更新日期:2010-12-01 00:00:00

  • Pathogen burden and cortisol profiles over the day.

    abstract::Hypothalamic-pituitary-adrenocortical (HPA) regulation in adults is influenced by early psychosocial adversity, but the role of infectious disease history is poorly understood. We studied the association between cumulative pathogen burden and cortisol profile over the day in a sample of 317 healthy men and women aged ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Steptoe A,Gylfe A,Shamaei-Tousi A,Bergstrom S,Henderson B

    更新日期:2009-12-01 00:00:00

  • The seroepidemiology of Lyme borreliosis in zoo animals in Germany.

    abstract::We conducted the first seroepidemiological study to evaluate the exposure of zoo animals to Borrelia burgdorferi s.l. in German zoos and wildlife parks. A total of 1487 individuals representing 148 ungulate and carnivore species belonging to 19 families were examined using a non-species dependent ELISA. Specific antib...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Stoebel K,Schoenberg A,Streich WJ

    更新日期:2003-10-01 00:00:00

  • Influenza vaccine failure in the tropics: a retrospective cohort study of waning effectiveness.

    abstract::Influenza vaccine effectiveness (VE) wanes over the course of a temperate climate winter season but little data are available from tropical countries with year-round influenza virus activity. In Singapore, a retrospective cohort study of adults vaccinated from 2013 to 2017 was conducted. Influenza vaccine failure was ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章


    authors: Young BE,Mak TM,Ang LW,Sadarangani S,Ho HJ,Wilder-Smith A,Barkham T,Chen M

    更新日期:2020-12-02 00:00:00