Abstract：
:Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Uddin LQ,Kelly AM,Biswal BB,Margulies DS,Shehzad Z,Shaw D,Ghaffari M,Rotrosen J,Adler LA,Castellanos FX,Milham MPdoi
10.1016/j.jneumeth.2007.11.031subject
Has Abstractpub_date
2008-03-30 00:00:00pages
249-54issue
1eissn
0165-0270issn
1872-678Xpii
S0165-0270(07)00601-2journal_volume
169pub_type
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