Abstract:
OBJECTIVES:Quality of life is reduced in inflammatory bowel disease. Irritable bowel syndrome (IBS)-like symptoms seem to be common in inflammatory bowel disease patients during the remission phase. We aimed to (i) assess the prevalence of IBS-like symptoms in ulcerative colitis (UC) patients during the remission phase and (ii) evaluate the impact of IBS symptoms on health-related quality of life (HRQOL) of UC patients in remission compared with the HRQOL of those in the active phase. METHODS:Ninety-five patients with UC (45 patients in the active phase and 50 in remission for at least 12 months) and 100 selected controls (recruited from among those who visited the orthopedic minor trauma outpatient clinic during 2004-2005) completed questionnaires to evaluate IBS-like symptoms according to ROME II criteria: the influence of these symptoms on the HRQOL of UC patients in remission was compared with that on the HRQOL of those in the active phase. Chi square and nonparametric tests were used. RESULTS:The prevalence of IBS-like symptoms in UC patients in remission and controls were 46 and 13%, respectively (P<0.001). HRQOL seemed to be significantly reduced in both active UC patients and UC patients in remission with IBS, compared with UC patients in remission without IBS and with controls (P<0.001). In active UC patients, the mean scores for most elements (as measured by SF36) were considerably lower than for UC patients in remission (P<0.05). CONCLUSION:The prevalence of IBS-like symptoms in UC patients in remission is about three times higher than in controls, and these patients have impaired HRQOL comparable with that of UC patients in the active phase.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Ansari R,Attari F,Razjouyan H,Etemadi A,Amjadi H,Merat S,Malekzadeh Rdoi
10.1097/MEG.0b013e3282f16a62subject
Has Abstractpub_date
2008-01-01 00:00:00pages
46-50issue
1eissn
0954-691Xissn
1473-5687pii
00042737-200801000-00010journal_volume
20pub_type
杂志文章abstract:OBJECTIVES:Cells infected with the hepatitis B or C virus can be eliminated by an immune response mediated by cytotoxic T cells. Recently, the Fas Ligand has been detected on the surface of cytotoxic T cells, and is thought to induce cells to apoptosis by adhering to the Fas antigen. METHODS:To evaluate the role of th...
journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,meta分析
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journal_title:European journal of gastroenterology & hepatology
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journal_title:European journal of gastroenterology & hepatology
pub_type: 杂志文章,评审
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journal_title:European journal of gastroenterology & hepatology
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