Expression of Fas antigen in liver tissue of patients with chronic hepatitis B and C.

Abstract:

OBJECTIVES:Cells infected with the hepatitis B or C virus can be eliminated by an immune response mediated by cytotoxic T cells. Recently, the Fas Ligand has been detected on the surface of cytotoxic T cells, and is thought to induce cells to apoptosis by adhering to the Fas antigen. METHODS:To evaluate the role of the Fas antigen and apoptosis in chronic hepatitis B or C, we used immunohistochemistry to study Fas antigen expression in liver samples obtained from 30 patients infected with chronic hepatitis B and 32 patients with chronic hepatitis C. RESULTS:In samples from patients with chronic hepatitis C and B, Fas antigen was mainly expressed in the cytoplasm (partly at the membrane) of hepatocytes, and these positive cells were detected especially at the periportal region near 'piecemeal necrosis'. According to Knodell's scoring system for the histological activity index, the scores of periportal inflammation and necrosis were higher in cases that were positive for Fas antigen than in cases that were negative for the antigen (n = 62, P < 0.001) and there was a positive correlation between these scores and the degree of Fas antigen expression (r = 0.621). There was also a positive correlation between the scores of intralobular inflammation and necrosis and the degree of Fas antigen expression (n = 62, r = 0.522, P = 0.001). Fas antigen was not detected in patients without hepatitis infection. CONCLUSIONS:These findings suggest that apoptosis of hepatocytes is induced via the Fas antigen and contributes to the elimination of infected cells.

authors

Oksuz M,Akkiz H,Isiksal YF,Seydaoglu G,Serin M,Kayaselcuk F,Abayli B,Tuncer I

doi

10.1097/00042737-200403000-00015

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

341-5

issue

3

eissn

0954-691X

issn

1473-5687

journal_volume

16

pub_type

杂志文章
  • Surgical management of gallbladder disease in the very elderly: are we operating them at the right time?

    abstract:BACKGROUND:As life expectancy rises worldwide and the prevalence of gallstones increases with age, the number of very elderly patients requiring treatment for gallstone diseases is increasing. The aim of this study was to compare the results of cholecystectomy in patients 80 years or older according to different clinic...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32835b7124

    authors: Lupinacci RM,Nadal LR,Rego RE,Dias AR,Marcari RS,Lupinacci RA,Farah JF

    更新日期:2013-03-01 00:00:00

  • Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study.

    abstract:OBJECTIVES:The aetiology of ulcerative colitis (UC) is largely unknown, although it is plausible that dietary n-3 polyunsaturated fatty acids (PUFAs) may be protective. Metabolites derived from n-3 PUFAs are less proinflammatory than those from n-6 PUFAs. Earlier, no prospective cohort studies have investigated this hy...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283352d05

    authors: John S,Luben R,Shrestha SS,Welch A,Khaw KT,Hart AR

    更新日期:2010-05-01 00:00:00

  • Proton and phosphorus-31 nuclear magnetic resonance spectroscopy of human bile in hepatopancreaticobiliary cancer.

    abstract:OBJECTIVE:Hepatopancreaticobiliary cancers can be difficult to diagnose. Nuclear magnetic resonance (NMR) spectroscopy provides non-invasive information on phospholipid metabolism, and previous studies of liver tissue have highlighted changes in phospholipids in malignancy. We hypothesised that in-vitro NMR spectroscop...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200507000-00007

    authors: Khan SA,Cox IJ,Thillainayagam AV,Bansi DS,Thomas HC,Taylor-Robinson SD

    更新日期:2005-07-01 00:00:00

  • Paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome: therapeutic challenge with bone marrow transplantation, transjugular intrahepatic portosystemic shunt, and vena cava stent.

    abstract::Stenosis of inferior vena cava can be a cause of or a consequence of Budd-Chiari syndrome (BCS). However, its occurrence after transjugular intrahepatic portosystemic shunt (TIPS) insertion has only been twice reported. We report the case of a 23-year-old man who presented BCS of the three suprahepatic veins. The caus...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200504000-00011

    authors: Vergniol J,Laharie D,Drouillard J,Etienne G,Pigneux A,Plessier A,Couzigou P,de Lédinghen V

    更新日期:2005-04-01 00:00:00

  • Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis.

    abstract:BACKGROUND:Data from studies in patients with nonalcoholic steatohepatitis (NASH) suggest an increased hepatic fatty acid oxidation. We have previously shown higher fasting plasma bile acid concentrations in patients with NASH. In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-a...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328345c8c7

    authors: Dasarathy S,Yang Y,McCullough AJ,Marczewski S,Bennett C,Kalhan SC

    更新日期:2011-05-01 00:00:00

  • Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania.

    abstract:OBJECTIVES:Immunoproliferative small intestinal disease (IPSID) represents a spectrum of clinicopathological entities including alpha-chain disease and other types of lymphoplasmacytic proliferations of the lamina propria of the small intestine, presenting with severe malabsorption. IPSID has been described mainly in t...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000228976.64774.04

    authors: Economidou I,Manousos ON,Triantafillidis JK,Vaslamatzis MM,Zafiropoulou R,Papadakis T

    更新日期:2006-09-01 00:00:00

  • Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial.

    abstract:OBJECTIVE:For palliation of extrahepatic bile duct obstruction, self-expandable metal stents (SEMS) are superior to plastic stents in terms of stent patency and occurrence of stent dysfunction. We assessed health-related quality of life (HRQoL) after stent placement to investigate whether this also results in a differe...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0000000000000762

    authors: Walter D,van Boeckel PG,Groenen MJ,Weusten BL,Witteman BJ,Tan G,Brink MA,Nicolai J,Tan AC,Alderliesten J,Venneman NG,Laleman W,Jansen JM,Bodelier A,Wolters FL,van der Waaij LA,Breumelhof R,Peters FT,Scheffer RC,Stey

    更新日期:2017-02-01 00:00:00

  • Transjugular intrahepatic portosystemic stent-shunt (TIPSS) insertion as a prelude to orthotopic liver transplantation in patients with severe portal hypertension.

    abstract:OBJECTIVE:To investigate the impact of preoperative transjugular intrahepatic portosystemic stent-shunt (TIPSS) on patients undergoing liver transplantation. DESIGN:A retrospective non-randomized comparative clinical study. SETTING:Tertiary referral institution. PATIENTS, PARTICIPANTS:Twenty-four patients with liver...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199612000-00002

    authors: John TG,Jalan R,Stanley AJ,Redhead DN,Sanfey HA,Hayes PC,Garden OJ

    更新日期:1996-12-01 00:00:00

  • Two cases of inverted hyperplastic polyps of the colon and association with adenoma.

    abstract::Here we report two cases of inverted hyperplastic polyps of the colon. The first patient showed three inverted hyperplastic polyps in the ascending colon, one of which was associated with adenoma. We immunostained this adenoma-associated polyp using anti-beta-catenin antibody and found accumulation of beta-catenin in ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200401000-00016

    authors: Kuribayashi K,Ishii T,Ishidate T,Ban N,Hirata Y,Hashida H,Saito K,Iwashiro N,Ohara M,Ishizaka M,Azumad M,Hayashi T,Takayama T

    更新日期:2004-01-01 00:00:00

  • Qualitative and quantitative clinical evaluation of the laser-assisted ratio analyser for detection of Helicobacter pylori infection by (13)C-urea breath tests.

    abstract:OBJECTIVES:Currently, the (13)C-urea breath test is the reference method for non-invasive diagnosis of Helicobacter pylori infection and therapy control. Therefore, new technologies have been developed to measure the ratio of (13)CO(2)/(12)CO(2) in breath. The laser-assisted ratio analyser (LARA) device is based on opt...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200107000-00008

    authors: Braden B,Gelbmann C,Dietrich CF,Caspary WF,Schölmerich J,Lock G

    更新日期:2001-07-01 00:00:00

  • Hyperbaric oxygen as a treatment for malabsorption in a radiation-damaged short bowel.

    abstract::Radiation enteritis can be challenging to diagnose and treat. We report the case of a 44-year-old woman who was diagnosed with a squamous cell carcinoma of the cervix in 1978 and treated with hysterectomy and post-operative radiotherapy. Over the next 20 years she required multiple intestinal operations resulting in s...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200606000-00017

    authors: Huddy JE,Patel P,Johnson MW,Hamilton-Farrell MR,Ede RJ,Sanderson JD

    更新日期:2006-06-01 00:00:00

  • Validity of N-terminal propeptide of the brain natriuretic peptide in predicting left ventricular diastolic dysfunction diagnosed by tissue Doppler imaging in patients with chronic liver disease.

    abstract:BACKGROUND AND AIMS:Left ventricular diastolic dysfunction has been reported in patients with liver cirrhosis. Although conventional Doppler echocardiography has been used to assess diastolic filling dynamics, this technique is limited in diagnosing left ventricular diastolic dysfunction. The aim of the study was to va...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282fb7cd0

    authors: Raedle-Hurst TM,Welsch C,Forestier N,Kronenberger B,Hess G,Herrmann E,Zeuzem S,Raedle J

    更新日期:2008-09-01 00:00:00

  • Gastrointestinal allergy in adults.

    abstract::The prevalence of food allergy reaches 3% in the adult population. Chronic gastrointestinal allergy is a rare entity: 4.2% of food allergies in adults, and represents 3.2% of all intestinal disorders. Non-specific symptoms are the rule but eosinophilic gastrointestinal disorders are the subject of much interest. Endos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200512000-00005

    authors: Moneret-Vautrin AD

    更新日期:2005-12-01 00:00:00

  • Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.

    abstract:OBJECTIVES:The hybrid allele of the carboxyl ester lipase gene (CEL-HYB1) is a genetic risk factor for chronic pancreatitis (CP) although the mechanism promoting disease development is largely unknown. Here, we aimed to clinically describe subjects carrying the CEL-HYB1 allele and to elucidate why the protein product i...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001963

    authors: Tjora E,Gravdal A,Engjom T,Cnop M,Johansson BB,Dimcevski GG,Molven A,Fjeld K

    更新日期:2020-10-16 00:00:00

  • Epithelial cell-derived components induce transforming growth factor-alpha mRNA expression and epithelial cell proliferation in vitro.

    abstract:BACKGROUND:Epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha protect the gastrointestinal mucosa against injury. In response to mucosal injury TGF-alpha, but not EGF, is locally increasingly expressed in the mucosa of the rat colon and stomach 4-8 h after injury. The aim of our present study was ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200111000-00012

    authors: Hoffmann P,Dignass AU,Zeeh JM,Mazurkiewicz J,Holtmann G,Gerken G

    更新日期:2001-11-01 00:00:00

  • Trends in incidence of oesophageal and stomach cancer subtypes in Europe.

    abstract:OBJECTIVE:Time trend studies in the USA have shown that the incidences of adenocarcinomas of the oesophagus and gastric cardia have risen strongly since the 1970s, whereas the incidence of squamous cell carcinomas of the oesophagus has declined. Earlier, we found that the incidence of these adenocarcinomas also rose in...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32832ca091

    authors: Steevens J,Botterweck AA,Dirx MJ,van den Brandt PA,Schouten LJ

    更新日期:2010-06-01 00:00:00

  • Examining predictors of healthcare utilization in youth with inflammatory bowel disease.

    abstract:BACKGROUND AND AIMS:Traditional definitions of healthcare utilization (HCU) emphasize clinical visits and procedures. Clinic calls, an understudied form of HCU, occur with high frequency. Understanding and examining predictors of HCU, such as disease activity and parent distress, may help reduce overutilization. METHO...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000540

    authors: Wojtowicz AA,Plevinsky JM,Poulopoulos N,Schurman JV,Greenley RN

    更新日期:2016-04-01 00:00:00

  • Prevalence and risk factors of HCV infection in Poland.

    abstract:BACKGROUND:According to small studies carried out in preselected populations, the estimated prevalence of anti-hepatitis C virus (HCV) antibodies in Poland ranges from 0.6 to 2.1%. AIMS:The aim of this study was to evaluate the prevalence of anti-HCV and HCV RNA among patients and healthcare workers. METHODS:Anti-HCV...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e32834d173c

    authors: Flisiak R,Halota W,Horban A,Juszczyk J,Pawlowska M,Simon K

    更新日期:2011-11-01 00:00:00

  • Effectiveness of combined endoscopic ultrasound-guided fine-needle aspiration biopsy and stenting in patients with suspected pancreatic cancer.

    abstract:BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) can be coupled with endoscopic retrograde cholangiopancreatography in the same setting when biliary and/or duodenal stenting are required. AIMS:Our aim was to examine the effectiveness of EUS-FNA combined with stenting during the same sess...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328357cdfd

    authors: Camus M,Trouilloud I,Villacis AL,Mangialavori L,Duchmann JC,Gaudric M,Roseau G,Terris B,Mitry E,Chaussade S,Prat F

    更新日期:2012-11-01 00:00:00

  • Influence of biliary anastomosis on recovery from secondary biliary cirrhosis.

    abstract:OBJECTIVE:The influence of choledochoduodenostomy and choledochojejunostomy on the repair of hepatic lesions secondary to biliary obstruction is not well known. The aim of the present study was to compare the effects of choledochoduodenostomy and choledochojejunostomy on the recovery of these lesions in rats with bilia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283551fed

    authors: dos Santos JS,Kemp R,de Andrade MF,Neder L

    更新日期:2012-09-01 00:00:00

  • Treatment of chronic hepatitis C with pegylated interferon and ribavirin in treatment-naive patients in 'true life': a plea in favor of independent postmarketing evaluations.

    abstract:BACKGROUND:Results of treatments for chronic hepatitis C virus are only estimated and disclosed from pivotal trials. AIM:To report the 'true life' results of pegylated interferon and ribavirin in treatment-naive patients. METHODS:A prospective, multicenter observatory in 22 general hospitals. RESULTS:Five-hundred an...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/meg.0b013e32833bb4b0

    authors: Pariente A,Lahmek P,Duprat C,Denis J,Faroux R,Renou C,Nalet B,Morin T,Cadranel JF,Investigator Group belonging to Association Nationale des Gastroentérologues des Hôpitaux Généraux (ANGH).

    更新日期:2010-11-01 00:00:00

  • Association of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: case report and review of literature.

    abstract::Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required perman...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e328317f4c8

    authors: Lo YC,Chang SY,Sheng WH,Hung CC,Chang SC

    更新日期:2009-04-01 00:00:00

  • Clinical and microbiological characteristics associated with mortality in spontaneous bacterial peritonitis: a multicenter cohort study.

    abstract:OBJECTIVES:Spontaneous bacterial peritonitis (SBP) is a prevalent and high mortality complication of cirrhosis. We aimed to describe these patients' clinical and microbiological characteristics and evaluate their impact on outcomes. METHODS:This was a retrospective cohort study including 139 consecutive patients with ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000700

    authors: Oliveira AM,Branco JC,Barosa R,Rodrigues JA,Ramos L,Martins A,Karvellas CJ,Cardoso FS

    更新日期:2016-10-01 00:00:00

  • Amyloidosis of the gastrointestinal tract and the liver: clinical context, diagnosis and management.

    abstract::Amyloidosis is a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathologic...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0000000000000695

    authors: Syed U,Ching Companioni RA,Alkhawam H,Walfish A

    更新日期:2016-10-01 00:00:00

  • Ultrasonography in the diagnosis and monitoring of ascites in acute abdominal attacks of hereditary angioneurotic oedema.

    abstract:BACKGROUND:Hereditary angioneurotic oedema (HAE) is a rare cause of ascites. As acute abdominal attacks of the disease can mimic surgical emergencies, prompt and accurate diagnosis is essential. This study was undertaken to evaluate the usefulness of serial abdominal ultrasound (US) examinations. PATIENTS AND METHODS:...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200110000-00016

    authors: Farkas H,Harmat G,Kaposi PN,Karádi I,Fekete B,Füst G,Fáy K,Vass A,Varga L

    更新日期:2001-10-01 00:00:00

  • Refractory coeliac disease: remission with infliximab and immunomodulators.

    abstract::Coeliac disease is a T-cell-mediated enteropathy induced by gluten. A minority of patients who fail to respond to a gluten-free diet may require intervention with immunomodulating drugs. We report a case of refractory coeliac disease where remission was induced by the anti-tumour necrosis factor-alpha antibody inflixi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200506000-00012

    authors: Turner SM,Moorghen M,Probert CS

    更新日期:2005-06-01 00:00:00

  • Switching from branched-chain amino acid granules to branched-chain amino acid-enriched nutrient improves the branched-chain amino acid-to-tyrosine ratio in patients with cirrhosis with hypoalbuminemia: a prospective study.

    abstract:OBJECTIVE:The present study aimed to elucidate the effect of switching from branched-chain amino acid granules to branched-chain amino acid-enriched nutrient in patients with cirrhosis with hypoalbuminemia. METHODS:Twenty-six patients with cirrhosis with hypoalbuminemia despite treatment with branched-chain amino acid...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001544

    authors: Fukui A,Kawabe N,Hashimoto S,Kamei H,Yoshioka K

    更新日期:2020-04-01 00:00:00

  • Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatic fibrosis. Liver biopsy, because of its limitations and risks, might be considered an imperfect gold standard for assessing the severity of chronic liver diseases. In this study, we aimed to prospectively validate FibroTest (FT) and Act...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328336ec84

    authors: El-Shabrawi MH,Mohsen NA,Sherif MM,El-Karaksy HM,Abou-Yosef H,El-Sayed HM,Riad H,Bahaa N,Isa M,El-Hennawy A

    更新日期:2010-08-01 00:00:00

  • Epidemiology of cancer from the oral cavity and oropharynx.

    abstract::The classification of sites in tumors of the oral cavity, oropharynx, pharynx, and hypopharynx varies in the literature. More than 90% of these tumors of the mucosal lining are classified as squamous cell carcinoma developed from premalignant lesions such as leukoplakia and erythroleukoplakia. These carcinomas are ass...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e3283484795

    authors: Lambert R,Sauvaget C,de Camargo Cancela M,Sankaranarayanan R

    更新日期:2011-08-01 00:00:00

  • Occult obstetric trauma and anal incontinence.

    abstract::Obstetric trauma is by far the commonest cause of anal incontinence in women. Denervation and reinnervation of the pelvic floor and anal sphincter following vaginal delivery has been previously demonstrated. The advent of anal endosonography, however, has enabled the identification of occult anal sphincter defects fol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199705000-00002

    authors: Sultan AH,Stanton SL

    更新日期:1997-05-01 00:00:00