Systemic immune modulation using chemokine receptor 7 expressing porcine Sertoli cells.

abstract：:Acute humoral rejection remains the major barrier to long-term pig-to-primate xenograft survival, and microvascular thrombosis is a critical element of the rejection process. It appears that persistent endothelial cell activation and injury, by even low levels of anti-graft antibodies, eventually overwhelm the cellula...

journal_title：Xenotransplantation

authors： Cowan PJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The JAK/STAT (Janus Tyrosine Kinase, Signal Transducers and Activators of Transcription) pathway is associated with cytokine or growth factor receptors and it is critical for growth control, developmental regulation and homeostasis. The use of porcine ocular cells as putative xenotransplants appears theoreti...

journal_title：Xenotransplantation

authors： Fasler-Kan E,Barteneva NS,Ketterer S,Wunderlich K,Reschner A,Nurzhanova A,Flammer J,Huwyler J,Meyer P

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to diabetic patients. However, the global application of islet transplantation requires a ubiquitous source of beta cells. The xenotransplantation of porcine islets would provide such a source. Success in por...

journal_title：Xenotransplantation

authors： Pepper AR,Gall C,Mazzuca DM,Melling CW,White DJ

更新日期：2009-11-01 00:00:00

abstract：:Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by systemic depletion of C3. U...

journal_title：Xenotransplantation

authors： Fecke W,Farries TC,D'Cruz LG,Napper CM,Harrison RA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The continued presence of a primate antibody-mediated response to cells and organs from alpha1,3-galactosyltransferase gene-knockout (GTKO) pigs indicates that there may be antigens other than Gal alpha 1,3Gal (alpha Gal) against which primates have xenoreactive antibodies. Human and baboon sera were tested ...

journal_title：Xenotransplantation

authors： Yeh P,Ezzelarab M,Bovin N,Hara H,Long C,Tomiyama K,Sun F,Ayares D,Awwad M,Cooper DK

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:In the α1,3-galactosyltransferase knockout (α-GalT KO) pig era, identification of the non-Gal epitopes is necessary for successful pig-to-human xenotransplantation. Recently, we successfully detected α-Gal epitopes as well as Hanganutziu-Deicher (H-D) antigens from the N-glycans in the pig heart tissues, whi...

journal_title：Xenotransplantation

authors： Jeong HJ,Adhya M,Park HM,Kim YG,Kim BG

更新日期：2013-11-01 00:00:00

abstract：:My purpose in these remarks is to stimulate us to consider the vast array that nature has provided us in the differentiation of species, and to examine the possibility that some of these differences might prove useful in other species, including man. ...

journal_title：Xenotransplantation

authors： Reemtsma K

更新日期：2000-05-01 00:00:00

abstract：:Exposure to human serum induces the lysis of xenogeneic cells through natural antibodies and complement activation. The carbohydrate Galactose-alpha1,3-Galactose (Gal-alpha1,3-Gal) epitope, has been shown to be the principal antigenic determinant on target cells. This reaction is, therefore, particularly important for...

journal_title：Xenotransplantation

authors： Déglon N,Aubert V,Spertini F,Winkel L,Aebischer P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:As a step towards clinical cardiac xenotransplantation, our experimental heterotopic intrathoracic xenotransplantation model offers a beating and ejecting donor heart while retaining the recipient's native organ as a backup in case of graft failure. Clinically applicable immunosuppressive regimens (IS) were ...

journal_title：Xenotransplantation

authors： Abicht JM,Mayr T,Reichart B,Buchholz S,Werner F,Lutzmann I,Schmoeckel M,Bauer A,Thormann M,Langenmayer M,Herbach N,Pohla H,Herzog R,McGregor CG,Ayares D,Wolf E,Klymiuk N,Baehr A,Kind A,Hagl C,Ganswindt U,Belka C

更新日期：2015-11-01 00:00:00

abstract：:Orthotopic liver transplantation (OLT) is the only definitive treatment option for many patients with end-stage liver disease. Current supply of donor livers for OLT is not keeping up with the growing demand. To overcome this problem, a number of experimental strategies have been developed either to provide a bridge t...

journal_title：Xenotransplantation

authors： Aravalli RN

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Swine infectious pathogens, especially viruses, represent a potential public health risk associated with the use of pig tissues for xenotransplantation in humans. We hypothesized that porcine circovirus type I (PCV-1) may infect human mononuclear cells, resulting in ultrastructural alterations of the target ...

journal_title：Xenotransplantation

authors： Arteaga-Troncoso G,Guerra-Infante F,Rosales-Montaño LM,Díaz-García FJ,Flores-Medina S

更新日期：2005-11-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyoma...

journal_title：Xenotransplantation

authors： Wu HL,Weber WC,Shriver-Munsch C,Swanson T,Northrup M,Price H,Armantrout K,Robertson-LeVay M,Reed JS,Bateman KB,Mahyari E,Thomas A,Junell SL,Hobbs TR,Martin LD,MacAllister R,Bimber BN,Slifka MK,Legasse AW,Moats C,A

更新日期：2020-07-01 00:00:00

abstract：:The outstanding results recently obtained in islet xenotransplantation suggest that porcine islet clinical trials may soon be scientifically appropriate. Before the initiation of such clinical studies, however, it is essential that a series of key ethical and regulatory conditions are satisfied. As far as ethics is co...

journal_title：Xenotransplantation

authors： Cozzi E,Tallacchini M,Flanagan EB,Pierson RN 3rd,Sykes M,Vanderpool HY

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to further investigate the characteristics of both graft-infiltrating cells and splenocytes during acute vascular rejection (AVR), cell-mediated rejection and non-rejection of vascularized concordant xenografts, by analysing both proinflammatory [interleukin-1beta (IL-1beta) ...

journal_title：Xenotransplantation

authors： Lorant T,Krook H,Wilton J,Olausson M,Tufveson G,Korsgren O,Johnsson C

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Over time, the notion of public has evolved. While the concept of public was initially conceived of as a single undifferentiated entity, the common understanding is now that a variety of differentiated, multifaceted and multiple public(s) can be constructed for different purposes. This is equally true in xen...

journal_title：Xenotransplantation

authors： Sobbrio P,Jorqui M

更新日期：2014-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the immunosuppressive effect of tacrolimus (TAC) in discordant islet xenotransplantation. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in normoglycemic rats treated with TAC monotherapy, TAC plus other immunosuppressive drugs or c...

journal_title：Xenotransplantation

authors： Song Z,Zhang J,Bennet W,Wennberg L

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Little information is available regarding the precise swine leukocyte antigen (SLA)-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we identified SLA-derived immunogenic peptides that are presented in association with human HLA-A2 molecule. METHODS:The SLA-derive...

journal_title：Xenotransplantation

authors： Park CS,Im SA,Song S,Kim K,Lee CK

更新日期：2014-09-01 00:00:00

abstract：:Although xenografts have always held immeasurable potential as an inexhaustible source of donor organs, immunological barriers and physiological incompatibility have proved to be formidable obstacles to clinical utility. An exciting, new regenerative medicine-based approach termed "semi-xenotransplantation" (SX) seeks...

journal_title：Xenotransplantation

authors： Salvatori M,Peloso A,Katari R,Soker S,Lerut JP,Stratta RJ,Orlando G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Young people, and students in particular, generally have a positive attitude to xenotransplantation. We reported previously that university students attending their first year approved of the idea of transplanting animal organs into humans. The aim of this study was to evaluate the impact of a 3-yr course at...

journal_title：Xenotransplantation

authors： Canova D,De Bona M,Rumiati R,Masier A,Ermani M,Naccarato R,Cozzi E,Ancona E,Burra P

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes mellitus is a devastating disease for which there is currently no cure, but only lifetime management. Islet xenotransplantation is a promising technique for the restoration of blood glucose control in patients with diabetes mellitus. The purpose of this study was to explore the potential use ...

journal_title：Xenotransplantation

authors： Hani H,Allaudin ZN,Mohd-Lila MA,Ibrahim TA,Othman AM

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Porcine islet transplantation into diabetic non-human primates is considered most relevant in translational research supporting a clinical application. Most studies have focused on immunosuppressive protocols, while metabolic aspects have mainly been utilized in graft monitoring. We evaluated data from our g...

journal_title：Xenotransplantation

authors： Graham ML,Bellin MD,Papas KK,Hering BJ,Schuurman HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:We have successfully performed heart transplantation despite the most unfavourable risk factors for graft and patient survival: the presence of a high level of antibodies (Abs) against the donor's human leukocyte antigens (HLA) class I/II and blood group A1 antigens. The present study concerns post-transplan...

journal_title：Xenotransplantation

authors： Bućin D,Johansson S,Lindberg LO

更新日期：2006-03-01 00:00:00

abstract：:Decellularized bovine pericardium (DBP)-based biomeshes are the gold standard in reconstructive surgery. In order to prolong their stability after the transplantation, various chemical cross-linking strategies are employed. However, structural and functional properties of the biomeshes differ in dependence on the cros...

journal_title：Xenotransplantation

authors： Grebenik EA,Istranov LP,Istranova EV,Churbanov SN,Shavkuta BS,Dmitriev RI,Veryasova NN,Kotova SL,Kurkov AV,Shekhter AB,Timashev PS

更新日期：2019-05-01 00:00:00

abstract：:Fetal pig islets, xenografted after organ culture into non-immunosuppressed prediabetic NOD mice, are rejected within 10 days. Immunosuppression with anti-T cell (anti-CD4 and anti-CD3) monoclonal antibodies alone is highly effective in delaying graft rejection in this discordant model, but rejection eventually occurs...

journal_title：Xenotransplantation

authors： Koulmanda M,Kovarik J,Mandel TE

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Cell-based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only p...

journal_title：Xenotransplantation

authors： Li Y,Chen HS,Shaheen M,Joo DJ,Amiot BP,Rinaldo P,Nyberg SL

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The Westran pig has been purposely inbred for use in xenotransplantation. The herd originated in the wild from a limited gene pool and has been inbred by repeated full-sib matings for nine generations. METHODS:The aim of this study was to evaluate the level of inbreeding by functional assays, such as bi-dir...

journal_title：Xenotransplantation

authors： O'Connell PJ,Hawthorne WJ,Simond D,Chapman JR,Chen Y,Patel AT,Walters SN,Burgess J,Weston L,Stokes RA,Moran C,Allen R

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS:These values are available from baseline levels in animals subjected to tolera...

journal_title：Xenotransplantation

authors： Schuurman HJ,Smith HT,Cozzi E

更新日期：2004-11-01 00:00:00

abstract：:The process of islet xenograft rejection is still poorly understood. To elucidate further possible mechanism(s) involved in xenograft rejection, the effect of different immunization protocols was investigated. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in otherwise untreat...

journal_title：Xenotransplantation

authors： Korsgren O,Wallgren AC,Satake M,Karlsson-Parra A

更新日期：1999-11-01 00:00:00

abstract：AIM:to study whether sensitization to pig antigens results in humoral and/or cellular sensitization to alloantigens in baboons, and thus increases the risks of organ allotransplantation after xenotransplantation. Serum from baboons that were naive (n = 4), sensitized to Gal alpha 1,3Gal (Gal) antigens (n = 2), or sensi...

journal_title：Xenotransplantation

authors： Baertschiger RM,Dor FJ,Prabharasuth D,Kuwaki K,Cooper DK

更新日期：2004-01-01 00:00:00

abstract：:Xenotransplantation of porcine organs might provide an unlimited source of donor organs to treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with unknown pathogenic potential as an integral part of their genome. While until recently the risk of interspecies transmission of these porci...

journal_title：Xenotransplantation

authors： Blusch JH,Patience C,Martin U

更新日期：2002-07-01 00:00:00