Intragraft cytokine mRNA expression in rejecting and non-rejecting vascularized xenografts.

abstract：:Previous data suggest that natural anti-Galalpha1,3Gal (Gal) antibody (Ab) is produced by mature plasma cells. As thalidomide is effectively used in the treatment of patients with multiple myeloma, its effect on natural anti-Gal Ab production has been assessed in two baboons. During a 10-week course of thalidomide adm...

journal_title：Xenotransplantation

authors： Yamamoto S,Cooper DK

更新日期：2003-09-01 00:00:00

abstract：:The activation of the endothelial surface in xenografts is still a poorly understood process and the consequences are unpredictable. The role of Ca2+ -messaging during the activation of endothelial cells is well recognized and routinely measured by synthetic Ca2+ -sensitive fluorophors. However, these compounds requir...

journal_title：Xenotransplantation

authors： Wuensch A,Kameritsch P,Sfriso R,Jemiller EM,Bähr A,Kurome M,Kessler B,Kemter E,Kupatt C,Reichart B,Rieben R,Wolf E,Klymiuk N

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regene...

journal_title：Xenotransplantation

authors： Heinke S,Ludwig B,Schubert U,Schmid J,Kiss T,Steffen A,Bornstein S,Ludwig S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic modifications to pig cells have been made by sequential recombination in fetal fibroblasts and liver-derived cells followed by cross-breeding or somatic cell nuclea...

journal_title：Xenotransplantation

authors： Li P,Estrada JL,Burlak C,Montgomery J,Butler JR,Santos RM,Wang ZY,Paris LL,Blankenship RL,Downey SM,Tector M,Tector AJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In pig-to-nonhuman primate solid organ xenotransplantation using organs from donors transgenic for human decay-accelerating factor (hDAF), the main type of rejection is antibody-mediated (acute humoral xenograft rejection, AHXR). This occurs despite the complement-regulatory function of the transgene, neutra...

journal_title：Xenotransplantation

authors： Lam TT,Hausen B,Hook L,Lau M,Higgins J,Christians U,Jacobsen W,Baluom M,Duthaler R,Katopodis A,Chavez G,Cozzi E,Harrison R,Schuurman HJ,Borie D,Morris RE

更新日期：2005-01-01 00:00:00

abstract：:The process of islet xenograft rejection is still poorly understood. To elucidate further possible mechanism(s) involved in xenograft rejection, the effect of different immunization protocols was investigated. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in otherwise untreat...

journal_title：Xenotransplantation

authors： Korsgren O,Wallgren AC,Satake M,Karlsson-Parra A

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Dysregulation of coagulation is considered a major barrier against successful pig organ xenotransplantation in non-human primates. Inflammation is known to promote activation of coagulation. The role of pro-inflammatory factors as well as the relationship between inflammation and activation of coagulation in...

journal_title：Xenotransplantation

authors： Ezzelarab MB,Ekser B,Azimzadeh A,Lin CC,Zhao Y,Rodriguez R,Echeverri GJ,Iwase H,Long C,Hara H,Ayares D,Pierson RN,Thomson AW,Cooper DK

更新日期：2015-01-01 00:00:00

abstract：:Type I diabetes remains a significant clinical problem in need of a reliable, generally applicable solution. Both whole organ pancreas and islet allotransplantation have been shown to grant patients insulin independence, but organ availability has restricted these procedures to an exceptionally small subset of the dia...

journal_title：Xenotransplantation

authors： Samy KP,Martin BM,Turgeon NA,Kirk AD

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Both the complement and the coagulation systems play important roles in the development of hyperacute or acute antibody-mediated xenograft rejection. Atrase B is a novel metalloproteinase isolated from the venom of Naja atra. In this study, we investigated the inhibitory effects of atrase B on complement act...

journal_title：Xenotransplantation

authors： Fu C,Shi L,Huang X,Feng H,Tan X,Chen S,Zhu L,Sun Q,Chen G

更新日期：2020-09-01 00:00:00

abstract：:The use of xenogeneic porcine pancreatic islets has been shown to be a potentially promising alternative to using human allogeneic islets to treat insulin-dependent type 1 diabetes (T1D). This article provides an overview of the existing FDA regulatory framework that would be applied to the regulation of clinical tria...

journal_title：Xenotransplantation

authors： Arcidiacono JA,Evdokimov E,Lee MH,Jones J,Rudenko L,Schneider B,Snoy PJ,Wei CH,Wensky AK,Wonnacott K

更新日期：2010-09-01 00:00:00

abstract：:We investigated the predictive biomarkers for graft rejection in pig-to-non-human primate (NHP) full-thickness corneal xenotransplantation (n = 34). The graft score (0-12) was calculated based on opacity, edema, and vascularization. Scores ≥ 6 were defined as rejection. NHPs were divided into two groups: (a) graft rej...

journal_title：Xenotransplantation

authors： Yoon CH,Choi SH,Lee HJ,Kang HJ,Kim MK

更新日期：2019-07-01 00:00:00

abstract：:Post-transplantation infections are common in allograft recipients and should be expected in all immunocompromised hosts. Based on the need for immunosuppression in xenotransplantation, procedures developed to enhance safety in allotransplantation can be applied in future xenotransplantation clinical trials. Standardi...

journal_title：Xenotransplantation

authors： Nellore A,Fishman JA

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Xenotransplantation of porcine islets has emerged in recent decades as a potential treatment for type 1 diabetes (T1D). Current methods of detection, indicative of successful engraftment, occur downstream of actual islet death. Epigenetic biomarkers can be detected in circulating cell-free DNA (cfDNA) to pro...

journal_title：Xenotransplantation

authors： Faulk C,Mueller KR,Cheishvili D,Colwell M,Pepin AS,Syzf M,Hering BJ,Burlak C

更新日期：2020-03-01 00:00:00

abstract：:Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical transplantation. With the advent of nuclear transfer technologies, the production of transgenic swine has become a possibility. These animals have allowed transplant investigators to overcome humoral mechanis...

journal_title：Xenotransplantation

authors： Scalea J,Hanecamp I,Robson SC,Yamada K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Xenotransplantation of porcine islets can reverse diabetes in non-human primates. The remaining hurdles for clinical application include safe and effective T-cell-directed immunosuppression, but protection against the innate immune system and coagulation dysfunction may be more difficult to achieve. Islet-ta...

journal_title：Xenotransplantation

authors： Wijkstrom M,Bottino R,Iwase H,Hara H,Ekser B,van der Windt D,Long C,Toledo FG,Phelps CJ,Trucco M,Cooper DK,Ayares D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Extensive studies in rodents have identified olfactory ensheathing cells (OECs) as promising candidates for cell-based therapies of spinal cord and peripheral nerve injury. Previously, we demonstrated that short-term cultured adult porcine OECs can remyelinate the rodent and non-human primate spinal cord. He...

journal_title：Xenotransplantation

authors： Radtke C,Lankford KL,Wewetzer K,Imaizumi T,Fodor WL,Kocsis JD

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Young people, and students in particular, generally have a positive attitude to xenotransplantation. We reported previously that university students attending their first year approved of the idea of transplanting animal organs into humans. The aim of this study was to evaluate the impact of a 3-yr course at...

journal_title：Xenotransplantation

authors： Canova D,De Bona M,Rumiati R,Masier A,Ermani M,Naccarato R,Cozzi E,Ancona E,Burra P

更新日期：2006-05-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyoma...

journal_title：Xenotransplantation

authors： Wu HL,Weber WC,Shriver-Munsch C,Swanson T,Northrup M,Price H,Armantrout K,Robertson-LeVay M,Reed JS,Bateman KB,Mahyari E,Thomas A,Junell SL,Hobbs TR,Martin LD,MacAllister R,Bimber BN,Slifka MK,Legasse AW,Moats C,A

更新日期：2020-07-01 00:00:00

abstract：:The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosup...

journal_title：Xenotransplantation

authors： Platt JL,West LJ,Chinnock RE,Cascalho M

更新日期：2018-11-01 00:00:00

abstract：:Islet transplantation is a potential treatment for diabetes mellitus and porcine pancreata may provide a readily available source of islets. The size, number and distribution of islets within the pancreas may influence the choice of age of donor for xenotransplantation. Samples (n = 3 per age group) from the dorsal an...

journal_title：Xenotransplantation

authors： Jay TR,Heald KA,Carless NJ,Topham DE,Downing R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Autograft (AG) is the gold standard bone graft due to biocompatibility, osteoconductivity, osteogenicity, and osteoinductivity. Alternatives include allografts and xenografts (XG). METHODS:We investigated the osseointegration and biocompatibility of a decellularized porcine XG within a critical defect anima...

journal_title：Xenotransplantation

authors： Jinnah AH,Whitlock P,Willey JS,Danelson K,Kerr BA,Hassan OA,Emory CL,Smith TL,Bracey DN

更新日期：2020-11-26 00:00:00

abstract：AIM:to study whether sensitization to pig antigens results in humoral and/or cellular sensitization to alloantigens in baboons, and thus increases the risks of organ allotransplantation after xenotransplantation. Serum from baboons that were naive (n = 4), sensitized to Gal alpha 1,3Gal (Gal) antigens (n = 2), or sensi...

journal_title：Xenotransplantation

authors： Baertschiger RM,Dor FJ,Prabharasuth D,Kuwaki K,Cooper DK

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:ABI793 (ABI) is a human monoclonal antibody (mAb) specific for human CD154. To assess the suitability of ABI for baboon transplantation studies, we carried out in vitro studies to determine ABI's reactivity with baboon cells expressing CD154, performed in vivo pharmacokinetic studies in two baboons, and test...

journal_title：Xenotransplantation

authors： Knosalla C,Ryan DJ,Moran K,Gollackner B,Schuler W,Sachs DH,Awwad M,Schuurman HJ,Cooper DK

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Liver fibrosis results from accumulation of extracellular matrix components and is associated with many chronic hepatic diseases. There is to date no specific therapy for this disease, and patients receive treatment for its associated complications. Specific progenitor cells, known as oval cells, are present...

journal_title：Xenotransplantation

authors： Sáez-Lara MJ,Frecha C,Martín F,Abadía F,Toscano M,Gil A,Fontana L

更新日期：2006-11-01 00:00:00

abstract：:Acute humoral rejection remains the major barrier to long-term pig-to-primate xenograft survival, and microvascular thrombosis is a critical element of the rejection process. It appears that persistent endothelial cell activation and injury, by even low levels of anti-graft antibodies, eventually overwhelm the cellula...

journal_title：Xenotransplantation

authors： Cowan PJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Making xenotransplantation socially acceptable is the first step in working toward the promotion of this potential therapy option for providing transplant organs. OBJECTIVE:To analyze the attitude toward xenotransplantation among the Latin American population resident in Florida (the USA), and to determine ...

journal_title：Xenotransplantation

authors： Ríos A,López-Navas AI,Martínez-Alarcón L,Ramis G,Hernández AM,Ayala MA,Garrido G,Ramírez P,Parrilla P

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:  Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression): subsequently, the International Xenotransplantation Association has publishe...

journal_title：Xenotransplantation

authors： Graham ML,Schuurman HJ

更新日期：2013-01-01 00:00:00

abstract：:Type 1 diabetes can be cured by transplantation of isolated pancreatic islets. Because of the shortage of human donor tissue, adult porcine islets (APIs) constitute a possible alternative tissue source. Upon intraportal injection, islets are subjected to an instant blood-mediated inflammatory reaction (IBMIR) leading ...

journal_title：Xenotransplantation

authors： Ehrnfelt C,Kumagai-Braesch M,Uzunel M,Holgersson J

更新日期：2004-03-01 00:00:00

abstract：:We describe in this report the production and characterization of monoclonal antibodies (mAb) to the swine homologues of CD11a and CD18 antigens, and their use for phenotypic and functional analysis of porcine leukocytes. Monoclonal antibodies BL1H8 and BL2F1 precipitated two bands of approximately 170 and 95 kDa, whe...

journal_title：Xenotransplantation

authors： Alvarez B,Doménech N,Alonso F,Sánchez C,Gómez del Moral M,Ezquerra A,Domínguez J

更新日期：2000-11-01 00:00:00

abstract：:Liver xenografts transplanted from guinea pig to rat suffer from inadequate organ reperfusion and initial dysfunction, despite sufficient complement depletion using cobra venom factor (CVF). Reperfusion injury is prevented when complement depleted donors are treated with the prostacyclin analog epoprostenol. Histologi...

journal_title：Xenotransplantation

authors： Meyer zu Vilsendorf A,Link C,Jörns A,Nagel E,Köhl J

更新日期：2001-02-01 00:00:00