Donor-derived infections and infectious risk in xenotransplantation and allotransplantation.

abstract：BACKGROUND:Human cytomegalovirus (HCMV) infection or reactivation has been linked to allograft rejection resulting from endothelial injury and immune activation. In pig-to-human xenotransplantation, currently investigated to circumvent the shortage of human organs in transplantation medicine, the porcine endothelium wi...

journal_title：Xenotransplantation

authors： Millard AL,Häberli L,Sinzger C,Ghielmetti M,Schneider MK,Bossart W,Seebach JD,Mueller NJ

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:In the α1,3-galactosyltransferase knockout (α-GalT KO) pig era, identification of the non-Gal epitopes is necessary for successful pig-to-human xenotransplantation. Recently, we successfully detected α-Gal epitopes as well as Hanganutziu-Deicher (H-D) antigens from the N-glycans in the pig heart tissues, whi...

journal_title：Xenotransplantation

authors： Jeong HJ,Adhya M,Park HM,Kim YG,Kim BG

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:We have successfully performed heart transplantation despite the most unfavourable risk factors for graft and patient survival: the presence of a high level of antibodies (Abs) against the donor's human leukocyte antigens (HLA) class I/II and blood group A1 antigens. The present study concerns post-transplan...

journal_title：Xenotransplantation

authors： Bućin D,Johansson S,Lindberg LO

更新日期：2006-03-01 00:00:00

abstract：:The present study was undertaken to establish a rat-to-mouse vascularized small bowel xenotransplantation model to study acute vascular and hyperacute xenograft rejection, and xenogenic cell migration. Lewis rat small bowel grafts were transplanted heterotopically to group 1, Balb/c mice, and group 2, Balb/c mice pre-...

journal_title：Xenotransplantation

authors： Kiyochi H,Kellersmann R,Blömer A,Garcia BM,Zhang Z,Zhong R,Grant DR

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The induced antibodies against Galalpha1,3Gal (Gal) and non-Gal epitopes may contribute to delayed xenograft rejection (DXR). We asked whether blockade of the CD40/CD154 and CD28/B7 co-stimulatory pathways modulates the baboon elicited antibody response to pig Gal and non-Gal antigens. METHODS:Eighteen babo...

journal_title：Xenotransplantation

authors： Wu G,Pfeiffer S,Schröder C,Zhang T,Nguyen BN,Lea W,Kelishadi S,Atkinson JB,Schuurman HJ,White DJ,Azimzadeh AM,Pierson RN 3rd

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Cell-based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only p...

journal_title：Xenotransplantation

authors： Li Y,Chen HS,Shaheen M,Joo DJ,Amiot BP,Rinaldo P,Nyberg SL

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic modifications to pig cells have been made by sequential recombination in fetal fibroblasts and liver-derived cells followed by cross-breeding or somatic cell nuclea...

journal_title：Xenotransplantation

authors： Li P,Estrada JL,Burlak C,Montgomery J,Butler JR,Santos RM,Wang ZY,Paris LL,Blankenship RL,Downey SM,Tector M,Tector AJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Swine infectious pathogens, especially viruses, represent a potential public health risk associated with the use of pig tissues for xenotransplantation in humans. We hypothesized that porcine circovirus type I (PCV-1) may infect human mononuclear cells, resulting in ultrastructural alterations of the target ...

journal_title：Xenotransplantation

authors： Arteaga-Troncoso G,Guerra-Infante F,Rosales-Montaño LM,Díaz-García FJ,Flores-Medina S

更新日期：2005-11-01 00:00:00

abstract：:Development of coagulation disorders remains a major challenge in pig-to-primate organ xenotransplantation. Our previous studies demonstrated that porcine aortic endothelial cells (pAEC) activate human platelets to express tissue factor (TF). In this study, we investigated the molecular interaction between human plate...

journal_title：Xenotransplantation

authors： Ezzelarab MB,Liu YW,Lin CC,Long C,Ayares D,Dorling A,Cooper DK

更新日期：2014-01-01 00:00:00

abstract：:We describe in this report the production and characterization of monoclonal antibodies (mAb) to the swine homologues of CD11a and CD18 antigens, and their use for phenotypic and functional analysis of porcine leukocytes. Monoclonal antibodies BL1H8 and BL2F1 precipitated two bands of approximately 170 and 95 kDa, whe...

journal_title：Xenotransplantation

authors： Alvarez B,Doménech N,Alonso F,Sánchez C,Gómez del Moral M,Ezquerra A,Domínguez J

更新日期：2000-11-01 00:00:00

abstract：:The process of islet xenograft rejection is still poorly understood. To elucidate further possible mechanism(s) involved in xenograft rejection, the effect of different immunization protocols was investigated. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in otherwise untreat...

journal_title：Xenotransplantation

authors： Korsgren O,Wallgren AC,Satake M,Karlsson-Parra A

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Microvascular thrombosis is a prominent characteristic of delayed xenograft rejection, therefore the effects of antiplatelet therapy with aspirin and clopidogrel on long-term cardiac xenograft function was investigated in a heterotopic pig-to-baboon cardiac transplant model. METHODS:Donor hearts from human ...

journal_title：Xenotransplantation

authors： Schirmer JM,Fass DN,Byrne GW,Tazelaar HD,Logan JS,McGregor CG

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:  Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression): subsequently, the International Xenotransplantation Association has publishe...

journal_title：Xenotransplantation

authors： Graham ML,Schuurman HJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Young people, and students in particular, generally have a positive attitude to xenotransplantation. We reported previously that university students attending their first year approved of the idea of transplanting animal organs into humans. The aim of this study was to evaluate the impact of a 3-yr course at...

journal_title：Xenotransplantation

authors： Canova D,De Bona M,Rumiati R,Masier A,Ermani M,Naccarato R,Cozzi E,Ancona E,Burra P

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans. It has been previously demonstrated that PERV copy number and particularly expression le...

journal_title：Xenotransplantation

authors： Mourad NI,Crossan C,Cruikshank V,Scobie L,Gianello P

更新日期：2017-07-01 00:00:00

abstract：:Mouse CD4+ T cells efficiently develop in fetal pig thymus (FP THY) grafts and repopulate the periphery of T cell and NK cell-depleted, thymectomized (ATX) mice. However, efficient peripheral repopulation of mouse CD8+ T cells does not occur in these mice. We have therefore evaluated the maturation and function of mou...

journal_title：Xenotransplantation

authors： Zhao Y,Barth RN,Swenson K,Pearson DA,Sykes M

更新日期：1998-02-01 00:00:00

abstract：:We designed this study to define reference values of the cynomolgus monkey coagulation system, as the normal range of values has not been established. Measurement of coagulation function was determined by testing plasma samples from 30 healthy male cynomolgus monkeys. Prothrombin time (PT), PT activity, PT internation...

journal_title：Xenotransplantation

authors： Rhu J,Lee KW,Kim KS,Lee JS,Kim SJ,Park JB

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Porcine islet transplantation into diabetic non-human primates is considered most relevant in translational research supporting a clinical application. Most studies have focused on immunosuppressive protocols, while metabolic aspects have mainly been utilized in graft monitoring. We evaluated data from our g...

journal_title：Xenotransplantation

authors： Graham ML,Bellin MD,Papas KK,Hering BJ,Schuurman HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Blood group ABO-incompatible live donor (LD) renal transplantation may provide a significant source of organs. We report the results of our first 14 cases of ABO-incompatible LD renal transplantation using specific anti-A/B antibody (Ab) immunoadsorption (IA) and anti-CD20 monoclonal Ab (mAb) treatment. PATI...

journal_title：Xenotransplantation

authors： Nordén G,Briggs D,Cockwell P,Lipkin G,Mjörnstedt L,Mölne J,Ready A,Rydberg L,Samuelsson O,Svalander CT,Breimer ME

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This paper is based on a theological symposium presented at the International Xenotransplantation Association's 14th Congress held in Baltimore, MD, September, 2017. METHODS:The information explores the Jewish, Christian and Muslim theological perceptions and perspectives about cross-species (ie pig-to-huma...

journal_title：Xenotransplantation

authors： Paris W,Seidler RJH,FitzGerald K,Padela AI,Cozzi E,Cooper DKC

更新日期：2018-05-01 00:00:00

abstract：:Highly sensitized patients awaiting kidney transplantation may be potential candidates for future clinical trials using pig organ donors. Because of crossreactivity between human leucocyte antigens (HLA) and swine leucocyte antigens (SLA), such patients might have heightened T-cell responses to porcine xenoantigens. W...

journal_title：Xenotransplantation

authors： Oostingh GJ,Davies HF,Bradley JA,Taylor CJ

更新日期：2003-11-01 00:00:00

abstract：:The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosup...

journal_title：Xenotransplantation

authors： Platt JL,West LJ,Chinnock RE,Cascalho M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs. Although pig TNFR1 (pTNFR1) is known to mediate the effects of human TNF in a xenogeneic setting, it is unclear whether pig TNFR2 (pTNFR2) could cont...

journal_title：Xenotransplantation

authors： Uribe-Herranz M,Casinghino SR,Bosch-Presegué L,Fodor WL,Costa C

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Sertoli cells (SC) are known to have active mechanism for evading humoral immune response and are known to have immune modulatory effects in the presence of other antigens. This has led us to hypothesize that systemic immune modulating effect of SC might be optimized by their residence on peripheral lymph no...

journal_title：Xenotransplantation

authors： Lee HM,Lim HG,Oh BC,Park CS,Lee DS,Lee JR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Little information is available regarding the precise swine leukocyte antigen (SLA)-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we identified SLA-derived immunogenic peptides that are presented in association with human HLA-A2 molecule. METHODS:The SLA-derive...

journal_title：Xenotransplantation

authors： Park CS,Im SA,Song S,Kim K,Lee CK

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:Xenotransplantation using porcine organs may resolve a chronic shortage of donor organs for clinical transplantation if significant immunological barriers can be overcome. To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopic...

journal_title：Xenotransplantation

authors： Davila E,Byrne GW,LaBreche PT,McGregor HC,Schwab AK,Davies WR,Rao VP,Oi K,Tazelaar HD,Logan JS,McGregor CG

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Recently, we have shown that an immunosuppression regimen including costimulation blockade via anti-CD154 antibody significantly prolongs the cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon heterotopic xenotransplantation model. Unfortunately, many coagulation disorders were observed with the use ...

journal_title：Xenotransplantation

authors： Mohiuddin MM,Singh AK,Corcoran PC,Hoyt RF,Thomas ML 3rd,Lewis BG,Eckhaus M,Dabkowski NL,Belli AJ,Reimann KA,Ayares D,Horvath KA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to diabetic patients. However, the global application of islet transplantation requires a ubiquitous source of beta cells. The xenotransplantation of porcine islets would provide such a source. Success in por...

journal_title：Xenotransplantation

authors： Pepper AR,Gall C,Mazzuca DM,Melling CW,White DJ

更新日期：2009-11-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyoma...

journal_title：Xenotransplantation

authors： Wu HL,Weber WC,Shriver-Munsch C,Swanson T,Northrup M,Price H,Armantrout K,Robertson-LeVay M,Reed JS,Bateman KB,Mahyari E,Thomas A,Junell SL,Hobbs TR,Martin LD,MacAllister R,Bimber BN,Slifka MK,Legasse AW,Moats C,A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Intravascular thrombosis and systemic coagulation abnormalities are major hurdles to successful xenotransplantation and are signs of acute humoral rejection. Increased expression of tissue factor (TF) is associated with the development of microvascular thrombosis in xenografts. To develop an effective strate...

journal_title：Xenotransplantation

authors： Lee KG,Lee H,Ha JM,Lee YK,Kang HJ,Park CG,Kim SJ

更新日期：2012-05-01 00:00:00