Address by the Honorary Founding President of the Xenotransplantation Society. The eye of an eagle: xenobiology and the quest for bioadvantage.


:My purpose in these remarks is to stimulate us to consider the vast array that nature has provided us in the differentiation of species, and to examine the possibility that some of these differences might prove useful in other species, including man.






Reemtsma K




Has Abstract


2000-05-01 00:00:00












  • Real-time assessment of encapsulated neonatal porcine islets prior to clinical xenotransplantation.

    abstract:BACKGROUND:Porcine islet transplantation is emerging as an attractive option for the treatment of patients with type 1 diabetes, with the possibility of providing islets of higher and more consistent quality and in larger volumes than available from human pancreata. The use of encapsulated neonatal porcine islets (ENPI...


    pub_type: 杂志文章


    authors: Kitzmann JP,Law L,Shome A,Muzina M,Elliott RB,Mueller KR,Schuurman HJ,Papas KK

    更新日期:2012-11-01 00:00:00

  • Identification of soluble and membrane-bound isoforms of porcine tumor necrosis factor receptor 2.

    abstract:BACKGROUND:TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs. Although pig TNFR1 (pTNFR1) is known to mediate the effects of human TNF in a xenogeneic setting, it is unclear whether pig TNFR2 (pTNFR2) could cont...


    pub_type: 杂志文章


    authors: Uribe-Herranz M,Casinghino SR,Bosch-Presegué L,Fodor WL,Costa C

    更新日期:2011-03-01 00:00:00

  • Investigation of potential carbohydrate antigen targets for human and baboon antibodies.

    abstract:BACKGROUND:The continued presence of a primate antibody-mediated response to cells and organs from alpha1,3-galactosyltransferase gene-knockout (GTKO) pigs indicates that there may be antigens other than Gal alpha 1,3Gal (alpha Gal) against which primates have xenoreactive antibodies. Human and baboon sera were tested ...


    pub_type: 杂志文章


    authors: Yeh P,Ezzelarab M,Bovin N,Hara H,Long C,Tomiyama K,Sun F,Ayares D,Awwad M,Cooper DK

    更新日期:2010-05-01 00:00:00

  • Immortalization of porcine hepatocytes with a α-1,3-galactosyltransferase knockout background.

    abstract:BACKGROUND:In vivo pig liver xenotransplantation preclinical trials appear to have poor efficiency compared to heart or kidney xenotransplantation because of xenogeneic rejection, including coagulopathy, and particularly thrombocytopenia. In contrast, ex vivo pig liver (wild type) perfusion systems have been proven to ...


    pub_type: 杂志文章


    authors: Wang Q,Zhang X,Wang B,Bai G,Pan D,Yang P,Tao K,Li X,Dou K

    更新日期:2020-01-01 00:00:00

  • An investigation of the effect of thalidomide on anti-gal antibody production in baboons.

    abstract::Previous data suggest that natural anti-Galalpha1,3Gal (Gal) antibody (Ab) is produced by mature plasma cells. As thalidomide is effectively used in the treatment of patients with multiple myeloma, its effect on natural anti-Gal Ab production has been assessed in two baboons. During a 10-week course of thalidomide adm...


    pub_type: 杂志文章


    authors: Yamamoto S,Cooper DK

    更新日期:2003-09-01 00:00:00

  • Atrase B, a novel metalloprotease with anti-complement and anti-coagulant activity, significantly delays discordant cardiac xenograft rejection.

    abstract:BACKGROUND:Both the complement and the coagulation systems play important roles in the development of hyperacute or acute antibody-mediated xenograft rejection. Atrase B is a novel metalloproteinase isolated from the venom of Naja atra. In this study, we investigated the inhibitory effects of atrase B on complement act...


    pub_type: 杂志文章


    authors: Fu C,Shi L,Huang X,Feng H,Tan X,Chen S,Zhu L,Sun Q,Chen G

    更新日期:2020-09-01 00:00:00

  • An overview of the role of society and risk in xenotransplantation.

    abstract:BACKGROUND:Over time, the notion of public has evolved. While the concept of public was initially conceived of as a single undifferentiated entity, the common understanding is now that a variety of differentiated, multifaceted and multiple public(s) can be constructed for different purposes. This is equally true in xen...


    pub_type: 杂志文章,评审


    authors: Sobbrio P,Jorqui M

    更新日期:2014-11-01 00:00:00

  • Reference values for clinical chemistry and clinical hematology parameters in baboons.

    abstract:BACKGROUND:In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS:These values are available from baseline levels in animals subjected to tolera...


    pub_type: 杂志文章


    authors: Schuurman HJ,Smith HT,Cozzi E

    更新日期:2004-11-01 00:00:00

  • Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival.

    abstract:BACKGROUND:Microvascular thrombosis is a prominent characteristic of delayed xenograft rejection, therefore the effects of antiplatelet therapy with aspirin and clopidogrel on long-term cardiac xenograft function was investigated in a heterotopic pig-to-baboon cardiac transplant model. METHODS:Donor hearts from human ...


    pub_type: 杂志文章


    authors: Schirmer JM,Fass DN,Byrne GW,Tazelaar HD,Logan JS,McGregor CG

    更新日期:2004-09-01 00:00:00

  • Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: a feasible approach for advanced diabetes research.

    abstract:BACKGROUND:Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regene...


    pub_type: 杂志文章


    authors: Heinke S,Ludwig B,Schubert U,Schmid J,Kiss T,Steffen A,Bornstein S,Ludwig S

    更新日期:2016-09-01 00:00:00

  • Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver.

    abstract:BACKGROUND AND AIMS:Cell-based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only p...


    pub_type: 杂志文章


    authors: Li Y,Chen HS,Shaheen M,Joo DJ,Amiot BP,Rinaldo P,Nyberg SL

    更新日期:2019-07-01 00:00:00

  • Pig islet xenografts are resistant to autoimmune destruction by non-obese diabetic recipients after anti-CD4 treatment.

    abstract::In addition to providing a large source of donor tissue, xenogeneic islet transplantation might avoid recurrent autoimmunity in patients with type 1 diabetes. To examine this possibility further, xenogeneic pig islets were transplanted into recipient mice in the presence or absence of autoimmunity. Spontaneously, non-...


    pub_type: 杂志文章


    authors: Koulmanda M,Qipo A,Smith RN,Auchincloss H Jr

    更新日期:2003-03-01 00:00:00

  • Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation.

    abstract:BACKGROUND:ABI793 (ABI) is a human monoclonal antibody (mAb) specific for human CD154. To assess the suitability of ABI for baboon transplantation studies, we carried out in vitro studies to determine ABI's reactivity with baboon cells expressing CD154, performed in vivo pharmacokinetic studies in two baboons, and test...


    pub_type: 杂志文章


    authors: Knosalla C,Ryan DJ,Moran K,Gollackner B,Schuler W,Sachs DH,Awwad M,Schuurman HJ,Cooper DK

    更新日期:2004-07-01 00:00:00

  • Bone xenotransplantation: A review of the history, orthopedic clinical literature, and a single-center case series.

    abstract:BACKGROUND:One-half of all orthopedic surgeries require bone grafting for successful outcomes in fusions, reconstructive procedures, and the treatment of osseous defects resulting from trauma, tumor, infection, or congenital deformity. Autologous bone grafts are taken from the patient's own body and remain the "gold st...


    pub_type: 杂志文章,评审


    authors: Bracey DN,Cignetti NE,Jinnah AH,Stone AV,Gyr BM,Whitlock PW,Scott AT

    更新日期:2020-09-01 00:00:00

  • The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.

    abstract:BACKGROUND:In pig-to-nonhuman primate solid organ xenotransplantation using organs from donors transgenic for human decay-accelerating factor (hDAF), the main type of rejection is antibody-mediated (acute humoral xenograft rejection, AHXR). This occurs despite the complement-regulatory function of the transgene, neutra...


    pub_type: 杂志文章


    authors: Lam TT,Hausen B,Hook L,Lau M,Higgins J,Christians U,Jacobsen W,Baluom M,Duthaler R,Katopodis A,Chavez G,Cozzi E,Harrison R,Schuurman HJ,Borie D,Morris RE

    更新日期:2005-01-01 00:00:00

  • Donor-derived infections and infectious risk in xenotransplantation and allotransplantation.

    abstract::Post-transplantation infections are common in allograft recipients and should be expected in all immunocompromised hosts. Based on the need for immunosuppression in xenotransplantation, procedures developed to enhance safety in allotransplantation can be applied in future xenotransplantation clinical trials. Standardi...


    pub_type: 杂志文章,评审


    authors: Nellore A,Fishman JA

    更新日期:2018-07-01 00:00:00

  • Toward a solution for cardiac failure in the newborn.

    abstract::The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosup...


    pub_type: 杂志文章,评审


    authors: Platt JL,West LJ,Chinnock RE,Cascalho M

    更新日期:2018-11-01 00:00:00

  • Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens.

    abstract:AIM:to study whether sensitization to pig antigens results in humoral and/or cellular sensitization to alloantigens in baboons, and thus increases the risks of organ allotransplantation after xenotransplantation. Serum from baboons that were naive (n = 4), sensitized to Gal alpha 1,3Gal (Gal) antigens (n = 2), or sensi...


    pub_type: 杂志文章


    authors: Baertschiger RM,Dor FJ,Prabharasuth D,Kuwaki K,Cooper DK

    更新日期:2004-01-01 00:00:00

  • Impaired spinal cord remyelination by long-term cultured adult porcine olfactory ensheathing cells correlates with altered in vitro phenotypic properties.

    abstract:BACKGROUND:Extensive studies in rodents have identified olfactory ensheathing cells (OECs) as promising candidates for cell-based therapies of spinal cord and peripheral nerve injury. Previously, we demonstrated that short-term cultured adult porcine OECs can remyelinate the rodent and non-human primate spinal cord. He...


    pub_type: 杂志文章


    authors: Radtke C,Lankford KL,Wewetzer K,Imaizumi T,Fodor WL,Kocsis JD

    更新日期:2010-01-01 00:00:00

  • T-cell responses during pig-to-primate xenotransplantation.

    abstract:UNLABELLED:Xenotransplantation using porcine organs may resolve a chronic shortage of donor organs for clinical transplantation if significant immunological barriers can be overcome. To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopic...


    pub_type: 杂志文章


    authors: Davila E,Byrne GW,LaBreche PT,McGregor HC,Schwab AK,Davies WR,Rao VP,Oi K,Tazelaar HD,Logan JS,McGregor CG

    更新日期:2006-01-01 00:00:00

  • Production of cloned pigs expressing human thrombomodulin in endothelial cells.

    abstract::For long-term xenograft survival, coagulation control is one of the remaining critical issues. Our attention has been directed toward human thrombomodulin (hTM), because it is expected to exhibit the following beneficial effects on coagulation control and cytoprotection: (i) to solve the problem of molecular incompati...


    pub_type: 杂志文章


    authors: Yazaki S,Iwamoto M,Onishi A,Miwa Y,Hashimoto M,Oishi T,Suzuki S,Fuchimoto D,Sembon S,Furusawa T,Liu D,Nagasaka T,Kuzuya T,Ogawa H,Yamamoto K,Iwasaki K,Haneda M,Maruyama S,Kobayashi T

    更新日期:2012-03-01 00:00:00

  • Expression of factor I-resistant mutants of the human complement component C3 in heterologous systems.

    abstract::Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by systemic depletion of C3. U...


    pub_type: 杂志文章


    authors: Fecke W,Farries TC,D'Cruz LG,Napper CM,Harrison RA

    更新日期:1998-02-01 00:00:00

  • Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation.

    abstract:BACKGROUND:The long-term viability and function of transplanted encapsulated neonatal porcine islets was examined in a diabetic patient. METHODS AND RESULTS:A 41-yr-old Caucasian male with type 1 diabetes for 18 yr was given an intraperitoneal transplant of alginate-encapsulated porcine islets at the dose of 15,000 is...


    pub_type: 杂志文章


    authors: Elliott RB,Escobar L,Tan PL,Muzina M,Zwain S,Buchanan C

    更新日期:2007-03-01 00:00:00

  • Microcirculatory alterations after orthotopic pig-to-baboon heart transplantation.

    abstract:BACKGROUND:Whilst macrohemodynamic function of porcine xenografts transplanted into baboons has been assessed perioperatively, the ability of the xenograft to maintain systemic microcirculatory perfusion has not been investigated after pig-to-baboon xenotransplantation so far. METHODS:We investigated the sublingual mi...


    pub_type: 杂志文章


    authors: Bauer A,Renz V,Baschnegger H,Abicht JM,Beiras-Fernandez A,Brenner P,Thein E,Schmoeckel M,Reichart B,Christ F

    更新日期:2011-07-01 00:00:00

  • Acceptance of organ xenotransplantation among Latin American immigrants resident in the United States.

    abstract:BACKGROUND:Making xenotransplantation socially acceptable is the first step in working toward the promotion of this potential therapy option for providing transplant organs. OBJECTIVE:To analyze the attitude toward xenotransplantation among the Latin American population resident in Florida (the USA), and to determine ...


    pub_type: 杂志文章


    authors: Ríos A,López-Navas AI,Martínez-Alarcón L,Ramis G,Hernández AM,Ayala MA,Garrido G,Ramírez P,Parrilla P

    更新日期:2016-07-01 00:00:00

  • Cyclophosphamide, but not CTLA4Ig, prolongs survival of fetal pig islet grafts in anti-T cell monoclonal antibody-treated NOD mice.

    abstract::Fetal pig islets, xenografted after organ culture into non-immunosuppressed prediabetic NOD mice, are rejected within 10 days. Immunosuppression with anti-T cell (anti-CD4 and anti-CD3) monoclonal antibodies alone is highly effective in delaying graft rejection in this discordant model, but rejection eventually occurs...


    pub_type: 杂志文章


    authors: Koulmanda M,Kovarik J,Mandel TE

    更新日期:1998-08-01 00:00:00

  • Islet cell xenotransplantation: a serious look toward the clinic.

    abstract::Type I diabetes remains a significant clinical problem in need of a reliable, generally applicable solution. Both whole organ pancreas and islet allotransplantation have been shown to grant patients insulin independence, but organ availability has restricted these procedures to an exceptionally small subset of the dia...


    pub_type: 杂志文章,评审


    authors: Samy KP,Martin BM,Turgeon NA,Kirk AD

    更新日期:2014-05-01 00:00:00

  • Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection.

    abstract:BACKGROUND:Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic modifications to pig cells have been made by sequential recombination in fetal fibroblasts and liver-derived cells followed by cross-breeding or somatic cell nuclea...


    pub_type: 杂志文章


    authors: Li P,Estrada JL,Burlak C,Montgomery J,Butler JR,Santos RM,Wang ZY,Paris LL,Blankenship RL,Downey SM,Tector M,Tector AJ

    更新日期:2015-01-01 00:00:00

  • Pig endogenous retroviruses and xenotransplantation.

    abstract::Xenotransplantation of porcine organs might provide an unlimited source of donor organs to treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with unknown pathogenic potential as an integral part of their genome. While until recently the risk of interspecies transmission of these porci...


    pub_type: 杂志文章,评审


    authors: Blusch JH,Patience C,Martin U

    更新日期:2002-07-01 00:00:00

  • Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model.

    abstract:BACKGROUND:Innovations in transgenic technology have facilitated improved xenograft survival. Additional gene expression appears to be necessary to overcome the remaining immune and biologic incompatibilities. We report for the first time the novel use of six-gene modifications within a pig-to-baboon cardiac xenotransp...


    pub_type: 杂志文章


    authors: Chan JL,Singh AK,Corcoran PC,Thomas ML,Lewis BG,Ayares DL,Vaught T,Horvath KA,Mohiuddin MM

    更新日期:2017-11-01 00:00:00