Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens.

abstract：BACKGROUND:Young people, and students in particular, generally have a positive attitude to xenotransplantation. We reported previously that university students attending their first year approved of the idea of transplanting animal organs into humans. The aim of this study was to evaluate the impact of a 3-yr course at...

journal_title：Xenotransplantation

authors： Canova D,De Bona M,Rumiati R,Masier A,Ermani M,Naccarato R,Cozzi E,Ancona E,Burra P

更新日期：2006-05-01 00:00:00

abstract：:Cultures of hDAF transgenic porcine aortic endothelial cells (TPAEs) with levels of cell surface hDAF expression between 2000 and 300 000 molecules per cell have been used to determine the relationship between expression of hDAF and protection from human complement deposition in an in vitro model. At concentrations be...

journal_title：Xenotransplantation

authors： Carrington CA,dos Santos Cruz G

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:  Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression): subsequently, the International Xenotransplantation Association has publishe...

journal_title：Xenotransplantation

authors： Graham ML,Schuurman HJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Innovations in transgenic technology have facilitated improved xenograft survival. Additional gene expression appears to be necessary to overcome the remaining immune and biologic incompatibilities. We report for the first time the novel use of six-gene modifications within a pig-to-baboon cardiac xenotransp...

journal_title：Xenotransplantation

authors： Chan JL,Singh AK,Corcoran PC,Thomas ML,Lewis BG,Ayares DL,Vaught T,Horvath KA,Mohiuddin MM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The continued presence of a primate antibody-mediated response to cells and organs from alpha1,3-galactosyltransferase gene-knockout (GTKO) pigs indicates that there may be antigens other than Gal alpha 1,3Gal (alpha Gal) against which primates have xenoreactive antibodies. Human and baboon sera were tested ...

journal_title：Xenotransplantation

authors： Yeh P,Ezzelarab M,Bovin N,Hara H,Long C,Tomiyama K,Sun F,Ayares D,Awwad M,Cooper DK

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Liver fibrosis results from accumulation of extracellular matrix components and is associated with many chronic hepatic diseases. There is to date no specific therapy for this disease, and patients receive treatment for its associated complications. Specific progenitor cells, known as oval cells, are present...

journal_title：Xenotransplantation

authors： Sáez-Lara MJ,Frecha C,Martín F,Abadía F,Toscano M,Gil A,Fontana L

更新日期：2006-11-01 00:00:00

abstract：:Although xenografts have always held immeasurable potential as an inexhaustible source of donor organs, immunological barriers and physiological incompatibility have proved to be formidable obstacles to clinical utility. An exciting, new regenerative medicine-based approach termed "semi-xenotransplantation" (SX) seeks...

journal_title：Xenotransplantation

authors： Salvatori M,Peloso A,Katari R,Soker S,Lerut JP,Stratta RJ,Orlando G

更新日期：2015-01-01 00:00:00

abstract：:Highly sensitized patients awaiting kidney transplantation may be potential candidates for future clinical trials using pig organ donors. Because of crossreactivity between human leucocyte antigens (HLA) and swine leucocyte antigens (SLA), such patients might have heightened T-cell responses to porcine xenoantigens. W...

journal_title：Xenotransplantation

authors： Oostingh GJ,Davies HF,Bradley JA,Taylor CJ

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic modifications to pig cells have been made by sequential recombination in fetal fibroblasts and liver-derived cells followed by cross-breeding or somatic cell nuclea...

journal_title：Xenotransplantation

authors： Li P,Estrada JL,Burlak C,Montgomery J,Butler JR,Santos RM,Wang ZY,Paris LL,Blankenship RL,Downey SM,Tector M,Tector AJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Over time, the notion of public has evolved. While the concept of public was initially conceived of as a single undifferentiated entity, the common understanding is now that a variety of differentiated, multifaceted and multiple public(s) can be constructed for different purposes. This is equally true in xen...

journal_title：Xenotransplantation

authors： Sobbrio P,Jorqui M

更新日期：2014-11-01 00:00:00

abstract：:The first blood transfusions in humans were xenotransfusions, carried out by Jean-Baptiste Denis beginning in 1667. Richard Lower, Matthäus Purmann and Georges Mercklin also experimented with the use of animal blood for transfusion until this practice was forbidden in 1670, after the death of one of Denis's patients. ...

journal_title：Xenotransplantation

authors： Roux FA,Saï P,Deschamps JY

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Sertoli cells (SC) are known to have active mechanism for evading humoral immune response and are known to have immune modulatory effects in the presence of other antigens. This has led us to hypothesize that systemic immune modulating effect of SC might be optimized by their residence on peripheral lymph no...

journal_title：Xenotransplantation

authors： Lee HM,Lim HG,Oh BC,Park CS,Lee DS,Lee JR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Blood group ABO-incompatible live donor (LD) renal transplantation may provide a significant source of organs. We report the results of our first 14 cases of ABO-incompatible LD renal transplantation using specific anti-A/B antibody (Ab) immunoadsorption (IA) and anti-CD20 monoclonal Ab (mAb) treatment. PATI...

journal_title：Xenotransplantation

authors： Nordén G,Briggs D,Cockwell P,Lipkin G,Mjörnstedt L,Mölne J,Ready A,Rydberg L,Samuelsson O,Svalander CT,Breimer ME

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This paper is based on a theological symposium presented at the International Xenotransplantation Association's 14th Congress held in Baltimore, MD, September, 2017. METHODS:The information explores the Jewish, Christian and Muslim theological perceptions and perspectives about cross-species (ie pig-to-huma...

journal_title：Xenotransplantation

authors： Paris W,Seidler RJH,FitzGerald K,Padela AI,Cozzi E,Cooper DKC

更新日期：2018-05-01 00:00:00

abstract：:The effects of pre-transplant blood transfusion vary from induction of antibodies and accelerated graft rejection, to prolonged survival and even tolerance. The beneficial 'transfusion effect' in allotransplantation is believed to be merely T-cell mediated. In xenotransplantation, T-cell independent mechanisms form a ...

journal_title：Xenotransplantation

authors： Vriens PW,Stoot JH,Hoyt G,Scheringa M,Bouwman E,Robbins RC

更新日期：2001-11-01 00:00:00

abstract：:The process of islet xenograft rejection is still poorly understood. To elucidate further possible mechanism(s) involved in xenograft rejection, the effect of different immunization protocols was investigated. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in otherwise untreat...

journal_title：Xenotransplantation

authors： Korsgren O,Wallgren AC,Satake M,Karlsson-Parra A

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The present study reports the development of a sensitive dot blot protocol for determining the level of preformed antibodies against porcine heart valve tissue derived from wild-type (WT) and α-Gal-KO (GGTA1-KO) pigs in human sera. METHODS:The assay uses decellularized and solubilized heart valve tissue; an...

journal_title：Xenotransplantation

authors： Smart I,Goecke T,Ramm R,Petersen B,Lenz D,Haverich A,Niemann H,Hilfiker A

更新日期：2020-09-17 00:00:00

abstract：:Islet transplantation is a potential treatment for diabetes mellitus and porcine pancreata may provide a readily available source of islets. The size, number and distribution of islets within the pancreas may influence the choice of age of donor for xenotransplantation. Samples (n = 3 per age group) from the dorsal an...

journal_title：Xenotransplantation

authors： Jay TR,Heald KA,Carless NJ,Topham DE,Downing R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:One-half of all orthopedic surgeries require bone grafting for successful outcomes in fusions, reconstructive procedures, and the treatment of osseous defects resulting from trauma, tumor, infection, or congenital deformity. Autologous bone grafts are taken from the patient's own body and remain the "gold st...

journal_title：Xenotransplantation

authors： Bracey DN,Cignetti NE,Jinnah AH,Stone AV,Gyr BM,Whitlock PW,Scott AT

更新日期：2020-09-01 00:00:00

abstract：:Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by systemic depletion of C3. U...

journal_title：Xenotransplantation

authors： Fecke W,Farries TC,D'Cruz LG,Napper CM,Harrison RA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:We have successfully performed heart transplantation despite the most unfavourable risk factors for graft and patient survival: the presence of a high level of antibodies (Abs) against the donor's human leukocyte antigens (HLA) class I/II and blood group A1 antigens. The present study concerns post-transplan...

journal_title：Xenotransplantation

authors： Bućin D,Johansson S,Lindberg LO

更新日期：2006-03-01 00:00:00

abstract：:Xenotransplantation of porcine organs might provide an unlimited source of donor organs to treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with unknown pathogenic potential as an integral part of their genome. While until recently the risk of interspecies transmission of these porci...

journal_title：Xenotransplantation

authors： Blusch JH,Patience C,Martin U

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Activation of the clotting cascade is central in acute xenograft rejection (AHXR) that occurs when pig organs are transplanted into primates. The coagulopathy reported in this model is a very complex process that involves simultaneously coagulation factors, platelets and phospholipid-bearing cells (i.e., leu...

journal_title：Xenotransplantation

authors： Spiezia L,Boldrin M,Radu C,Bulato C,Bertini D,Bon M,Campello E,Vadori M,Galli C,Gavasso S,Nottle MB,Cowan PJ,Cozzi E,Simioni P

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:ABI793 (ABI) is a human monoclonal antibody (mAb) specific for human CD154. To assess the suitability of ABI for baboon transplantation studies, we carried out in vitro studies to determine ABI's reactivity with baboon cells expressing CD154, performed in vivo pharmacokinetic studies in two baboons, and test...

journal_title：Xenotransplantation

authors： Knosalla C,Ryan DJ,Moran K,Gollackner B,Schuler W,Sachs DH,Awwad M,Schuurman HJ,Cooper DK

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regene...

journal_title：Xenotransplantation

authors： Heinke S,Ludwig B,Schubert U,Schmid J,Kiss T,Steffen A,Bornstein S,Ludwig S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Extensive studies in rodents have identified olfactory ensheathing cells (OECs) as promising candidates for cell-based therapies of spinal cord and peripheral nerve injury. Previously, we demonstrated that short-term cultured adult porcine OECs can remyelinate the rodent and non-human primate spinal cord. He...

journal_title：Xenotransplantation

authors： Radtke C,Lankford KL,Wewetzer K,Imaizumi T,Fodor WL,Kocsis JD

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:In the α1,3-galactosyltransferase knockout (α-GalT KO) pig era, identification of the non-Gal epitopes is necessary for successful pig-to-human xenotransplantation. Recently, we successfully detected α-Gal epitopes as well as Hanganutziu-Deicher (H-D) antigens from the N-glycans in the pig heart tissues, whi...

journal_title：Xenotransplantation

authors： Jeong HJ,Adhya M,Park HM,Kim YG,Kim BG

更新日期：2013-11-01 00:00:00

abstract：:Mouse CD4+ T cells efficiently develop in fetal pig thymus (FP THY) grafts and repopulate the periphery of T cell and NK cell-depleted, thymectomized (ATX) mice. However, efficient peripheral repopulation of mouse CD8+ T cells does not occur in these mice. We have therefore evaluated the maturation and function of mou...

journal_title：Xenotransplantation

authors： Zhao Y,Barth RN,Swenson K,Pearson DA,Sykes M

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Making xenotransplantation socially acceptable is the first step in working toward the promotion of this potential therapy option for providing transplant organs. OBJECTIVE:To analyze the attitude toward xenotransplantation among the Latin American population resident in Florida (the USA), and to determine ...

journal_title：Xenotransplantation

authors： Ríos A,López-Navas AI,Martínez-Alarcón L,Ramis G,Hernández AM,Ayala MA,Garrido G,Ramírez P,Parrilla P

更新日期：2016-07-01 00:00:00

abstract：:My purpose in these remarks is to stimulate us to consider the vast array that nature has provided us in the differentiation of species, and to examine the possibility that some of these differences might prove useful in other species, including man. ...

journal_title：Xenotransplantation

authors： Reemtsma K

更新日期：2000-05-01 00:00:00