Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation.

abstract：BACKGROUND:In pig-to-nonhuman primate solid organ xenotransplantation using organs from donors transgenic for human decay-accelerating factor (hDAF), the main type of rejection is antibody-mediated (acute humoral xenograft rejection, AHXR). This occurs despite the complement-regulatory function of the transgene, neutra...

journal_title：Xenotransplantation

authors： Lam TT,Hausen B,Hook L,Lau M,Higgins J,Christians U,Jacobsen W,Baluom M,Duthaler R,Katopodis A,Chavez G,Cozzi E,Harrison R,Schuurman HJ,Borie D,Morris RE

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Over time, the notion of public has evolved. While the concept of public was initially conceived of as a single undifferentiated entity, the common understanding is now that a variety of differentiated, multifaceted and multiple public(s) can be constructed for different purposes. This is equally true in xen...

journal_title：Xenotransplantation

authors： Sobbrio P,Jorqui M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs. Although pig TNFR1 (pTNFR1) is known to mediate the effects of human TNF in a xenogeneic setting, it is unclear whether pig TNFR2 (pTNFR2) could cont...

journal_title：Xenotransplantation

authors： Uribe-Herranz M,Casinghino SR,Bosch-Presegué L,Fodor WL,Costa C

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to further investigate the characteristics of both graft-infiltrating cells and splenocytes during acute vascular rejection (AVR), cell-mediated rejection and non-rejection of vascularized concordant xenografts, by analysing both proinflammatory [interleukin-1beta (IL-1beta) ...

journal_title：Xenotransplantation

authors： Lorant T,Krook H,Wilton J,Olausson M,Tufveson G,Korsgren O,Johnsson C

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Little information is available regarding the precise swine leukocyte antigen (SLA)-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we identified SLA-derived immunogenic peptides that are presented in association with human HLA-A2 molecule. METHODS:The SLA-derive...

journal_title：Xenotransplantation

authors： Park CS,Im SA,Song S,Kim K,Lee CK

更新日期：2014-09-01 00:00:00

abstract：:Xenotransplantation of porcine organs might provide an unlimited source of donor organs to treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with unknown pathogenic potential as an integral part of their genome. While until recently the risk of interspecies transmission of these porci...

journal_title：Xenotransplantation

authors： Blusch JH,Patience C,Martin U

更新日期：2002-07-01 00:00:00

abstract：:Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by systemic depletion of C3. U...

journal_title：Xenotransplantation

authors： Fecke W,Farries TC,D'Cruz LG,Napper CM,Harrison RA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Descemet's membrane endothelial keratoplasty (DMEK) might be a promising technique for future xeno-corneal transplantation due to its ultrathin graft, extremely low rejection occurrence, suture-free graft fixation, and minimal immunosuppressive regime usage. The aim of this study is to explore the feasibilit...

journal_title：Xenotransplantation

authors： Liu Y,Zhang J,Zhang Y,Yin M,Miao S,Liang Q,Pan Z

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Xenotransplantation of porcine islets can reverse diabetes in non-human primates. The remaining hurdles for clinical application include safe and effective T-cell-directed immunosuppression, but protection against the innate immune system and coagulation dysfunction may be more difficult to achieve. Islet-ta...

journal_title：Xenotransplantation

authors： Wijkstrom M,Bottino R,Iwase H,Hara H,Ekser B,van der Windt D,Long C,Toledo FG,Phelps CJ,Trucco M,Cooper DK,Ayares D

更新日期：2015-01-01 00:00:00

abstract：:Decellularized bovine pericardium (DBP)-based biomeshes are the gold standard in reconstructive surgery. In order to prolong their stability after the transplantation, various chemical cross-linking strategies are employed. However, structural and functional properties of the biomeshes differ in dependence on the cros...

journal_title：Xenotransplantation

authors： Grebenik EA,Istranov LP,Istranova EV,Churbanov SN,Shavkuta BS,Dmitriev RI,Veryasova NN,Kotova SL,Kurkov AV,Shekhter AB,Timashev PS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In vivo pig liver xenotransplantation preclinical trials appear to have poor efficiency compared to heart or kidney xenotransplantation because of xenogeneic rejection, including coagulopathy, and particularly thrombocytopenia. In contrast, ex vivo pig liver (wild type) perfusion systems have been proven to ...

journal_title：Xenotransplantation

authors： Wang Q,Zhang X,Wang B,Bai G,Pan D,Yang P,Tao K,Li X,Dou K

更新日期：2020-01-01 00:00:00

abstract：:Cultures of hDAF transgenic porcine aortic endothelial cells (TPAEs) with levels of cell surface hDAF expression between 2000 and 300 000 molecules per cell have been used to determine the relationship between expression of hDAF and protection from human complement deposition in an in vitro model. At concentrations be...

journal_title：Xenotransplantation

authors： Carrington CA,dos Santos Cruz G

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The present study reports the development of a sensitive dot blot protocol for determining the level of preformed antibodies against porcine heart valve tissue derived from wild-type (WT) and α-Gal-KO (GGTA1-KO) pigs in human sera. METHODS:The assay uses decellularized and solubilized heart valve tissue; an...

journal_title：Xenotransplantation

authors： Smart I,Goecke T,Ramm R,Petersen B,Lenz D,Haverich A,Niemann H,Hilfiker A

更新日期：2020-09-17 00:00:00

abstract：:Type I diabetes remains a significant clinical problem in need of a reliable, generally applicable solution. Both whole organ pancreas and islet allotransplantation have been shown to grant patients insulin independence, but organ availability has restricted these procedures to an exceptionally small subset of the dia...

journal_title：Xenotransplantation

authors： Samy KP,Martin BM,Turgeon NA,Kirk AD

更新日期：2014-05-01 00:00:00

abstract：:We investigated the predictive biomarkers for graft rejection in pig-to-non-human primate (NHP) full-thickness corneal xenotransplantation (n = 34). The graft score (0-12) was calculated based on opacity, edema, and vascularization. Scores ≥ 6 were defined as rejection. NHPs were divided into two groups: (a) graft rej...

journal_title：Xenotransplantation

authors： Yoon CH,Choi SH,Lee HJ,Kang HJ,Kim MK

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to diabetic patients. However, the global application of islet transplantation requires a ubiquitous source of beta cells. The xenotransplantation of porcine islets would provide such a source. Success in por...

journal_title：Xenotransplantation

authors： Pepper AR,Gall C,Mazzuca DM,Melling CW,White DJ

更新日期：2009-11-01 00:00:00

abstract：:The last 15 years or so have seen exciting progress in xenotransplantation, with porcine organ grafts surviving months or even years in non-human primates. These advances reflect the application of new scientific knowledge, improved immunosuppressive agents, and genetic engineering. The field has recently enjoyed a re...

journal_title：Xenotransplantation

authors： Sykes M

更新日期：2018-05-01 00:00:00

abstract：:Islet transplantation is a potential treatment for diabetes mellitus and porcine pancreata may provide a readily available source of islets. The size, number and distribution of islets within the pancreas may influence the choice of age of donor for xenotransplantation. Samples (n = 3 per age group) from the dorsal an...

journal_title：Xenotransplantation

authors： Jay TR,Heald KA,Carless NJ,Topham DE,Downing R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Autograft (AG) is the gold standard bone graft due to biocompatibility, osteoconductivity, osteogenicity, and osteoinductivity. Alternatives include allografts and xenografts (XG). METHODS:We investigated the osseointegration and biocompatibility of a decellularized porcine XG within a critical defect anima...

journal_title：Xenotransplantation

authors： Jinnah AH,Whitlock P,Willey JS,Danelson K,Kerr BA,Hassan OA,Emory CL,Smith TL,Bracey DN

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regene...

journal_title：Xenotransplantation

authors： Heinke S,Ludwig B,Schubert U,Schmid J,Kiss T,Steffen A,Bornstein S,Ludwig S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Porcine islet transplantation into diabetic non-human primates is considered most relevant in translational research supporting a clinical application. Most studies have focused on immunosuppressive protocols, while metabolic aspects have mainly been utilized in graft monitoring. We evaluated data from our g...

journal_title：Xenotransplantation

authors： Graham ML,Bellin MD,Papas KK,Hering BJ,Schuurman HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Ubiquitous expression of T-cell regulatory transgenes such as the cytotoxic T lymphocyte-associated antigen 4 (CTLA4) or the high-affinity variant LEA29Y improves xeno graft survival. Such donor pigs are however immunocompromised and susceptible to infection. Continous high expression of CTLA4 or LEA29Y in t...

journal_title：Xenotransplantation

authors： Fischer A,Manske K,Seissler J,Wohlleber D,Simm N,Wolf-van Buerck L,Knolle P,Schnieke A,Fischer K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Sertoli cells (SC) are known to have active mechanism for evading humoral immune response and are known to have immune modulatory effects in the presence of other antigens. This has led us to hypothesize that systemic immune modulating effect of SC might be optimized by their residence on peripheral lymph no...

journal_title：Xenotransplantation

authors： Lee HM,Lim HG,Oh BC,Park CS,Lee DS,Lee JR

更新日期：2007-11-01 00:00:00

abstract：:Exposure to human serum induces the lysis of xenogeneic cells through natural antibodies and complement activation. The carbohydrate Galactose-alpha1,3-Galactose (Gal-alpha1,3-Gal) epitope, has been shown to be the principal antigenic determinant on target cells. This reaction is, therefore, particularly important for...

journal_title：Xenotransplantation

authors： Déglon N,Aubert V,Spertini F,Winkel L,Aebischer P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Pancreatic islets are composed of different hormone-secreting cell types. A finely balanced combination of endocrine cells in the islets regulates intraportal vein secretions and plasma nutrient levels. Every islet cell type is distinguished by its specific secretory granule pattern and hormone content, endo...

journal_title：Xenotransplantation

authors： Hani H,Nazariah Allaudin Z,Mohd-Lila MA,Sarsaifi K,Tengku-Ibrahim TA,Mazni Othman A

更新日期：2016-03-01 00:00:00

abstract：:The present historical review reports the clinical experiences of transplantations from animal to human. The first transplantation attempts were made without any knowledge of the species barrier. The pioneers of xenotransplantation realized xenotransfusions as early as the 16th century, then cell and tissue xenotransp...

journal_title：Xenotransplantation

authors： Deschamps JY,Roux FA,Saï P,Gouin E

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS:These values are available from baseline levels in animals subjected to tolera...

journal_title：Xenotransplantation

authors： Schuurman HJ,Smith HT,Cozzi E

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Whilst macrohemodynamic function of porcine xenografts transplanted into baboons has been assessed perioperatively, the ability of the xenograft to maintain systemic microcirculatory perfusion has not been investigated after pig-to-baboon xenotransplantation so far. METHODS:We investigated the sublingual mi...

journal_title：Xenotransplantation

authors： Bauer A,Renz V,Baschnegger H,Abicht JM,Beiras-Fernandez A,Brenner P,Thein E,Schmoeckel M,Reichart B,Christ F

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Despite overcoming xenograft hyperacute rejection (HAR), Gal (galactose-alpha1,3-galactose) expression may not be completely eliminated from the alpha1,3-galactosyltransferase gene knockout (Gal KO) pig because of alternative galactosyltransferases. Whether low levels of "residual" Gal are still susceptible ...

journal_title：Xenotransplantation

authors： Murray-Segal L,Gock H,Cowan PJ,d'Apice AJ

更新日期：2008-02-01 00:00:00

abstract：:Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical transplantation. With the advent of nuclear transfer technologies, the production of transgenic swine has become a possibility. These animals have allowed transplant investigators to overcome humoral mechanis...

journal_title：Xenotransplantation

authors： Scalea J,Hanecamp I,Robson SC,Yamada K

更新日期：2012-01-01 00:00:00