Abstract：
OBJECTIVES:Analyse the effects of anti-tumor necrosis factor therapy on serum levels of lipid in patients with rheumatoid arthritis (RA). METHODS:Twenty-nine patients (26 females, 3 males) with established RA undergoing anti-TNF therapy (n=12, adalimumab; n=11, infliximab; n=6, etanercept) were recruited. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides (TG), and apolipoproteins (apo b and apo a) were assessed at baseline and after 14 weeks of treatment. RESULTS:The disease activity index score (DAS(28)) was 5.19+/-0.90 and decreased to 3.46+/-0.97 at 16 weeks (p<0.001). There was no change neither in the levels of TC (5.65+/-0.98mmol/l vs 5.78+/-1.06mmol/l; p=0.43), TG (1.40+/-0.79mmol/l vs 1.45+/-0.67mmol/l; p=0.59), HDL-C (1.92+/-0.49mmol/l vs 1.97+/-0.49mmol/l; p=0.36), apo a1 (1.92+/-0.28g/l vs 1.99+/-0.29g/l; p=0.06), and LDL-C (3.41+/-0.91mmol/l vs 3.47+/-0.96mmol/l; p=0.66), nor in apo b (1.126+/-0.302g/l vs 1.13+/-0.28g/l; p=0.89), atherogenic index (3.13+/-1.05 vs 3.09+/-0.89; p=0.69) or the apo b/apo a1 ratio (0.58+/-0.25 vs 0.56+/-0.22; p=0.33). CONCLUSION:The favourable effect of anti-tumor necrosis factor therapy on cardiovascular morbidity is not related to effects on lipid metabolism.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Soubrier M,Jouanel P,Mathieu S,Poujol D,Claus D,Dubost JJ,Ristori JMdoi
10.1016/j.jbspin.2007.04.014subject
Has Abstractpub_date
2008-01-01 00:00:00pages
22-4issue
1eissn
1297-319Xissn
1778-7254pii
S1297-319X(07)00248-5journal_volume
75pub_type
杂志文章相关文献
JOINT BONE SPINE文献大全abstract：OBJECTIVE:To assess the patients' information about biosimilars and to identify the patients' incentives and deterrents to concur with the use of biosimilars. METHODS:Nation-wide cross-sectional study assessing information and concerns about biosimilars of French patients treated for rheumatic inflammatory diseases, w...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2019.01.001
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Uveitis is a frequent extra rheumatological manifestation in axial Spondyloarthritis (SpA). The aim of study was to evaluate the prevalence and incidence of uveitis over the first five years of a prospective nationwide cohort of patients with high suspicion of early axial SpA, and to evaluate its associated f...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.105100
更新日期：2020-11-06 00:00:00
abstract：OBJECTIVE:Opticin is a class III member of the small leucine-rich repeat proteoglycan (SLRP) family, produced in articular joint tissues. In normal and osteoarthritic (OA) cartilage, opticin is degraded. This study aimed to assess whether human cartilage opticin is degraded by the main proteases involved in OA pathophy...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2013.05.007
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:To explore acceptance and retention rate of biosimilar CT-P13 after switching from originator infliximab (OI) in patients with various rheumatic diseases. METHODS:Patients with stable rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriatic arthritis (PsA) under OI were proposed to switch to CT-P1...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.10.003
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To compare the frequency of different autoantibodies in a group of patients with Jaccoud's arthropathy (JA) secondary to systemic lupus erythematosus (SLE) with those without JA. METHODS:A group of SLE patients with JA was compared with another group of SLE patients without this complication, matched by age ...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.11.003
更新日期：2009-07-01 00:00:00
abstract：:Pseudo-xanthoma elasticum (PXE) is an inherited disorder of the connective tissue characterized by cutaneous, ocular and vascular lesions. Coexisting PXE and rheumatoid arthritis (RA) is rare because three cases have only been described. We report three new cases of this association. Analysis of these six cases failed...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(01)00317-7
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Although the cause of adolescent idiopathic scoliosis remains unclear, pinealectomy is followed by the development of scoliosis in chickens. Melatonin is the only hormone secreted by pineal gland. OBJECTIVE:To assess serum melatonin levels in adolescents with idiopathic scoliosis. METHODS:Serum melatonin w...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:FRAX™ is a fracture prediction algorithm to determine a patient's absolute fracture risk. There is a growing consensus that osteoporosis treatment should be based on individual 10-year fracture probability, as calculated in the FRAX™ algorithm, rather than on T-scores alone. OBJECTIVE:Our objective was to eval...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2012.01.001
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:This study explores changes in the bone homeostasis by testing the N-terminal collagen type I extension propeptide (PINP) marker for osteo-formation and the carboxy-terminal region of collagen type I (CTX-I) marker for osteo-resorption in patients taking tocilizumab for polymyalgia rheumatica (PMR). METHODS...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2020.105117
更新日期：2020-12-07 00:00:00
abstract：BACKGROUND:Behcet's disease (BD) may complicate with arterial and venous thrombosis. The purpose of this work is to evaluate in an Italian group of BD patients with thrombotic events a large panel of inherited and acquired thrombophilic factors. METHODS:Thirty BD patients, of which nine with previously arterial or ven...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2010.02.022
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) is a common, complex autoimmune disease known to be associated with inheritance of certain human leukocyte antigen (HLA)-DR alleles in different populations. This study investigated the association of DRB1 alleles in Kuwaiti patients with RA. MATERIALS AND METHODS:DRB1 alleles were...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2004.12.006
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:Diagnosis of systemic sclerosis (SSc) is partially determined by the presence of specific autoantibodies often associated with specific clinical features. Recent studies report the presence of ACPA in SSc. We aimed to evaluate the prevalence of ACPA in SSc and to assess their influence on clinical presentati...
journal_title：Joint bone spine
pub_type： 杂志文章,meta分析
doi：10.1016/j.jbspin.2017.11.006
更新日期：2018-03-01 00:00:00
abstract：:Calcification of the ligamentum flavum is a rare manifestation of the calcium pyrophosphate dihydrate deposition disease (CPPD). In CPPD deposition disease, spinal involvement is rare. Until now, thoracic spine CPPD causing thoracic cord compression has been reported in only sporadic cases. We report a new case of tho...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.01.029
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVES:Candidate cell types for disc cell transplantation therapy include anulus fibrosus (AF) cells, chondrocytes, and bone marrow derived cells (BMDCs). We compared the disc matrix production in these three types of cells, before and after stimulation with rhBMP-2. There is no study extant that compares these thr...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2008.02.021
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:Interleukin (IL)-1β blocking is effective for the treatment of gout flares and is recommended in patients with contraindications to the standard of care, such as stage 4-5 chronic kidney disease (CKD) patients. However, efficacy and safety data regarding these agents are lacking in this population. We aimed ...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jbspin.2018.03.015
更新日期：2018-12-01 00:00:00
abstract：:We report on a 46-year-old woman, who developed streptococcus B septic polyarthritis in the context of septicemia of urinary origin. This case revealed a Good's syndrome whose diagnosis was made on the basis of a profound hypogammaglobulinaemia, a large decrease of peripheral B cells and a thymoma disclosed on chest c...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2012.03.009
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:To evaluate observer agreement using the Larsen system (LS) and a Modified Larsen system (ML) when assessing individual joints of the hands and wrists in rheumatoid arthritis, and to compare the two systems. To determine the minimally important difference (MID) for the ML. METHODS:Thirty radiographs of hand...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2003.07.009
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:Cysticercosis, a parasitic disease caused by encysted larvae of the tapeworm Taenia solium, is commonly seen in developing countries and in immigrant population of developed countries. The most common presentation is as neuro cysticercosis, but rarely may have an extra cerebral muscular presentation. METHOD...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.04.022
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To determine the very long-term clinical and functional outcomes in rheumatoid arthritis (RA) patients followed by office-based or hospital-based physicians. PATIENTS AND METHODS:A questionnaire including items on clinical outcomes (active disease, remission, burn-out) and the Health Assessment Questionnaire...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/s1297-319x(02)00370-6
更新日期：2002-03-01 00:00:00
abstract：:Clinical data suggested that parathyroid hormone (PTH) might be effective in improving bone mass in patients with osteoporosis, providing its resorptive effects, which are particularly marked at cortical sites, were kept under control. We reviewed the evidence that intermittent PTH therapy is a valid treatment option ...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2005.11.007
更新日期：2006-05-01 00:00:00
abstract：UNLABELLED:Botulinum toxin is a proven and widely used treatment for numerous conditions characterized by excessive muscular contractions. Recent studies have assessed the analgesic effect of botulinum toxin in joint pain and started to unravel its mechanisms. LITERATURE-SEARCH-METHODOLOGY:We searched the internationa...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2015.10.001
更新日期：2016-03-01 00:00:00
abstract：:Rheumatoid arthritis is the most common of all chronic inflammatory joint diseases. Treatment should be initiated early, if possible within the first six months after symptom onset, and should be selected according to the potential for disease progression. Early initiation of combination drug therapy may improve quali...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2004.04.009
更新日期：2005-03-01 00:00:00
abstract：:The gradual reductions in bone mass and skeletal calcium density seen throughout adulthood occur in parallel with changes in the production of bioactive sex hormones in both men and women. The long-held belief that osteoporosis is dependent on androgens in men and estrogens in women has been challenged by recent repor...
journal_title：Joint bone spine
pub_type： 杂志文章,评审
doi：10.1016/j.jbspin.2004.04.004
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:To assess the effect of periodontal treatment on clinical and biochemical parameters of rheumatoid arthritis (RA) and quality of life (QoL) in patients with moderately active RA who were diagnosed with periodontitis. METHODS:In this open-label randomised controlled trial, RA subjects (n = 22) were allocated...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jbspin.2019.02.006
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVES:Accumulating evidence suggests that gout is associated with increased overall and cardiovascular mortality. Using data from a large consecutive cohort of gout sufferers who were followed for 8 years, we investigated mortality among gout sufferers and compared the results with data from the general population...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2011.01.007
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:The personality of patients with fibromyalgia is still under debate. Some studies found high neuroticism associated with low extraversion, while others found that these traits do not differ from the normal population. Personality factors intervene in the emotional regulation and modulation of pain. The aim...
journal_title：Joint bone spine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jbspin.2016.03.006
更新日期：2017-03-01 00:00:00
abstract：:Tuberculosis of the craniocervical junction (CCJ) is exceedingly rare but carries a risk of compression of the medulla oblongata and upper spinal cord. Three cases among 63 patients with spinal tuberculosis are reported. Mean age was 51 years (range, 20-69) and mean time to diagnosis was 4.6 months (range, 1-8). Altho...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Anti-citrullinated protein/peptide antibodies (ACPA) represent an important tool for the diagnosis of rheumatoid arthritis (RA) and the presence of multiple ACPA specificities is highly correlated with the evolution towards RA. However, little is known about the association of single specificities with disea...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2017.07.009
更新日期：2018-07-01 00:00:00
abstract：:REPAIRING FULL THICKNESS CUFF TEARS.--Despite the sound rationale for repairing full-thickness rotator cuff tears, the procedure may fail to restore cuff integrity, which is indispensable to optimal cuff function. The functional role of each cuff muscle and the factors associated with anatomic failure (particularly th...
journal_title：Joint bone spine
pub_type：
doi：10.1016/j.jbspin.2003.08.003
更新日期：2003-12-01 00:00:00
abstract：:Vertebral osteonecrosis classically presents with an intravertebral vacuum cleft phenomenon or a fluid-filled cleft on MR images. These clefts are usually found in older patients presenting with more severe fractures, more significant collapse and instability. Therefore, although considered for a long time as pathogno...
journal_title：Joint bone spine
pub_type： 杂志文章
doi：10.1016/j.jbspin.2007.05.010
更新日期：2008-05-01 00:00:00
