Effect of maternal dexamethasone treatment on the type II pneumocytes in hypoplastic lung by oligohydramnios: an ultrastructural study.

Abstract:

:A previous study documented the effects of maternal corticosteroid treatment on structural growth and functional development in fetal lungs associated with pathogenic conditions such as oligohydramnios using immunohistochemical and morphometric analyses. The purpose of the present study was to examine the effect of maternal dexamethasone treatment the expression of lamellar body in type II pneumocytes of the fetal rabbit lungs with hypoplasia induced by oligohydramnios using electron microscopy. Using an amniotic shunting rabbit model, pregnant rabbits were injected intravenously with either 0.1 ml of saline or 0.25 mg/kg/day of dexamethasone in 0.1 ml of saline 48 and 24 h before the delivery of fetuses, at day 30 of gestation. The number of lamellar bodies per type II pneumocyte was counted in each group using electron micrographs. The number of lamellar bodies per type II pneumocyte in the lungs of the shunted group that received saline was consistently and significantly less than that of the other three groups (5.49 +/- 2.07 vs. 7.34 +/- 2.27: shunted group that received dexamethasone, 7.58 +/- 2.08: non-shunted group that received saline, 7.79 +/- 1.90: non-shunted group that received dexamethasone; P < 0.01). These results suggest that maternal dexamethasone treatment accelerates the maturation of the surfactant system, especially the expression of lamellar bodies in type II pneumocytes, even in hypoplastic lungs induced by oligohydramnios.

journal_name

Pediatr Surg Int

authors

Asabe K,Oka Y,Kai H,Shirakusa T

doi

10.1007/s00383-007-1979-6

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

967-70

issue

10

eissn

0179-0358

issn

1437-9813

journal_volume

23

pub_type

杂志文章
  • Utility of PAS and β-catenin staining in histological categorisation and prediction of prognosis of hepatoblastomas.

    abstract:AIMS:The aim of this study was to assess the usefulness of PAS, β-catenin and Ki-67 in categorising hepatoblastomas (HBs) and their significance in predicting prognosis. In addition, we have also documented the various chemotherapy induced histologic changes in HBs. METHOD:In this retrospective observational study of ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-017-4115-2

    authors: Bera G,Das RN,Roy P,Ghosh R,Islam N,Mishra PK,Chatterjee U

    更新日期:2017-09-01 00:00:00

  • What is the role of enhanced recovery after surgery in children? A scoping review.

    abstract:PURPOSE:Enhanced recovery after surgery (ERAS) pathways are standard practice in adult specialties resulting in improved outcomes. It is unclear whether ERAS principles are applicable to Paediatric Surgery. We performed a scoping review to identify the extent to which ERAS has been used in Paediatric Surgery, the natur...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-016-3986-y

    authors: Pearson KL,Hall NJ

    更新日期:2017-01-01 00:00:00

  • Is renal scintigraphy really a necessity in the routine diagnosis of congenital solitary kidney?

    abstract:BACKGROUND:For a definitive diagnosis of congenital solitary kidney, renal scintigraphy is suggested as being the gold standard of ruling out ectopic functioning renal tissue, possibly missed by ultrasound. The aim of our study was to test ultrasonography precision in comparison with renal scintigraphy on a larger coho...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-019-04478-1

    authors: Grabnar J,Rus RR

    更新日期:2019-06-01 00:00:00

  • NICE guidelines for imaging studies in children with UTI adequate only in boys under the age of 6 months.

    abstract:PURPOSE:The purpose of this study was to evaluate the applicability of the National Institute for Health and Clinical Excellence (NICE) guidelines for imaging studies in children under the age of three with first urinary tract infection (UTI). METHODS:In our cohort of 112 patients, we gathered data regarding the occur...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-012-3257-5

    authors: Ristola MT,Hurme T

    更新日期:2013-03-01 00:00:00

  • Borderline phylloides tumor in an 11-year-old girl.

    abstract::Phylloides tumor is an uncommon breast tumor in children. Only a few cases have been reported in the literature. A case of borderline phylloides tumor in an 11-year-old girl is described. ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050623

    authors: Selamzade M,Gidener C,Koyuncuoglu M,Mevsim A

    更新日期:1999-07-01 00:00:00

  • Management of colonic atresia with primary resection and anastomosis.

    abstract:PURPOSE:Historically, the majority of patients with colonic atresia have been managed by ostomy creation at the time of initial operation; conversely, we have tended to treat the atresia with resection and anastomosis. The purpose of this study is to determine the rate of concomitant Hirschsprung's disease and to ident...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-009-2401-3

    authors: Dassinger M,Jackson R,Smith S

    更新日期:2009-07-01 00:00:00

  • Manual reduction with the index finger for infantile intussusception. A modification of Hutchinson's maneuver.

    abstract::Manual reduction with the index finger (modified Hutchinson's maneuver) enabling simple and safe manual reduction of infantile intussusception is described. The procedure was used in four patients, two boys and two girls, ranging in age from 2 to 15 months, as greater than normal compression was necessary and/or seros...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050301

    authors: Hase T,Kodama M,Mizukuro T,Kishida A,Shimadera S,Ohno M,Shimada M

    更新日期:1998-03-01 00:00:00

  • Surgical jejunostomy and radiological gastro-jejunostomy tube feeding in children: risks, benefits and nutritional outcomes.

    abstract:PURPOSE:Radiologically inserted gastrojejunal tubes (RGJ) and surgical jejunostomy (SJ) are established modes of jejunal feeding. The aim of the study is to review nutritional outcomes, complications and the practical consideration to enable patients and carers to make informed choice. METHODS:Retrospective review of ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-018-4303-8

    authors: Singh RR,Eaton S,Roebuck DJ,Barnacle AM,Chippington S,Cross KMK,De Coppi P,Curry JI

    更新日期:2018-09-01 00:00:00

  • Surgical intervention and perioperative risk factors of retroperitoneal teratomas in children: a single institution experience.

    abstract:PURPOSE:Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative management. In this study, we retrospectively reviewed our series of RTs. METHODS:Seventy patients with germ cell tumors were treated from 1989 to 2015 in our i...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-016-3938-6

    authors: Fumino S,Maniwa J,Takeuchi Y,Sakai K,Higashi M,Aoi S,Furukawa T,Kimura O,Tajiri T

    更新日期:2016-09-01 00:00:00

  • Anorectal injuries in children.

    abstract::Anorectal injuries (ARI) are uncommon in children in civil practice. In developed countries the injuries are mainly due to sexual abuse and firearms. This report reviews the experience in tropical Africa. A retrospective study of children aged 12 years or less managed for ARI over 10 years was undertaken. There were s...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830000347

    authors: Ameh EA

    更新日期:2000-01-01 00:00:00

  • Embryogenesis of a sac containing a Meckel's diverticulum.

    abstract::The embryogenesis of a previously unreported mesothelial pouch containing a Meckel's diverticulum is presented. ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/BF01076960

    authors: Khatri HL,Singh RB,Sharma R,Aggarwal N,Singh K

    更新日期:1997-07-01 00:00:00

  • A pilot study comparing parent and adolescent online health information seeking behaviours in elective pediatric surgical situations.

    abstract:PURPOSE:Little is known of how children seek health information. This study evaluates online health information (OHI) seeking behaviours in adolescents undergoing major elective surgical procedures and compares responses within parent-child dyads. METHODS:With institutional approval, we prospectively surveyed parents ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-019-04592-0

    authors: Wong SSM,Wong KPL,Angus MIL,Chen Y,Choo CSC,Nah SA

    更新日期:2020-02-01 00:00:00

  • Cardiac rhabdomyoma as an unusual mediastinal mass in a newborn.

    abstract::A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-007-1875-0

    authors: Karnak I,Alehan D,Ekinci S,Büyükpamukçu N

    更新日期:2007-08-01 00:00:00

  • Embryological and clinical implications of the association between anorectal malformations and spinal dysraphisms.

    abstract:PURPOSE:To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. METHODS:Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-017-4104-5

    authors: Totonelli G,Messina R,Morini F,Mosiello G,Palma P,Scuglia M,Iacobelli BD,Bagolan P

    更新日期:2017-08-01 00:00:00

  • Gastric transposition in infants and children.

    abstract::The loss of esophageal length in long-gap esophageal atresia or obliteration of the esophageal lumen due to stricture may require major operative reconstruction. A number of procedures have been developed to allow anatomic replacement of the esophagus. The gastric transposition requires a single cervical anastomosis a...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-010-2736-9

    authors: Cowles RA,Coran AG

    更新日期:2010-12-01 00:00:00

  • The area and attachment abnormalities of the gubernaculum in patients with undescended testes in comparison with those with retractile testes.

    abstract:PURPOSE:In order to evaluate the gubernaculum (GN) abnormalities quantitatively in patients with undescended testes (UDT), the area and attachment site of the gubernaculum were evaluated. PATIENTS AND METHODS:Sixty-seven testes from 61 patients with an undescended testis treated in the past 11 years at our institution...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-014-3597-4

    authors: Kubota M,Nakaya K,Arai Y,Ohyama T,Yokota N,Nagai Y

    更新日期:2014-11-01 00:00:00

  • Nanomedicine: a primer for surgeons.

    abstract::The advances in science have resulted in the emergence of nanotechnology, which deals with the design and use of tools and devices of size 1-100 nm. The application of nanotechnologies to medicine is thus termed nanomedicine. Significant research has been focused on this new and exciting field and this review article ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-012-3162-y

    authors: Wong KK,Liu XL

    更新日期:2012-10-01 00:00:00

  • The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung's disease: a 30-year experience of 954 patients.

    abstract:PURPOSE:For 30 years, we have consecutively performed rectal mucosal punch biopsy to diagnose Hirschsprung's disease. The aim of this study was to evaluate the safety of our technique. METHODS:Patients with suspected Hirschsprung's disease who underwent punch biopsy, including our original "K-PUNCH" method using an S-...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-016-4010-2

    authors: Yoshimaru K,Kinoshita Y,Yanagi Y,Obata S,Jimbo T,Iwanaka T,Takahashi Y,Esumi G,Miyata JA,Matsuura T,Izaki T,Taguchi T

    更新日期:2017-02-01 00:00:00

  • Long-term outcomes of children undergoing video-assisted gastrostomy.

    abstract:PURPOSE:The aims of this study were to assess the short- and long-term complication rates after video-assisted gastrostomy (VAG), the effects of age and gender on long-term complications and the effect of duration of gastrostomy tube retention on the need for gastroraphy when the gastrostomy device was removed. METHOD...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-016-4001-3

    authors: Salö M,Santimano A,Helmroth S,Stenström P,Arnbjornsson EÓ

    更新日期:2017-01-01 00:00:00

  • Surgical complications, especially gastroesophageal reflux disease, intestinal adhesion obstruction, and diaphragmatic hernia recurrence, are major sequelae in survivors of congenital diaphragmatic hernia.

    abstract:PURPOSE:This study aimed to characterize the surgical complications, especially gastroesophageal reflux disease (GERD), intestinal adhesion obstruction (IAO), and diaphragmatic hernia recurrence, in patients with congenital diaphragmatic hernia (CDH). METHODS:Between January 1995 and December 2013, we determined the i...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-014-3575-x

    authors: Yokota K,Uchida H,Kaneko K,Ono Y,Murase N,Makita S,Hayakawa M

    更新日期:2014-09-01 00:00:00

  • Juvenile papillomatosis of the breast in a 9-year-old girl.

    abstract::Juvenile papillomatosis (JP) is a rare benign, proliferative breast tumor in children. We observed a 9-year-old girl with a large soft-tissue mass at the lower outer quadrant of the left breast. Ultrasonography showed an ill-defined, inhomogeneous mass with numerous small, hypoechoic areas. The tumor was completely ex...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830000462

    authors: Hsieh SC,Chen KC,Chu CC,Chou JM

    更新日期:2001-03-01 00:00:00

  • The role of thymectomy in the treatment of juvenile myasthenia gravis: a systematic review.

    abstract:BACKGROUND:The role of thymectomy in the treatment of juvenile myasthenia gravis (JMG) is poorly defined. The objective of this systematic review was to evaluate the effect of thymectomy on survival, disease severity, and peri-operative complications for patients with JMG. METHODS:A search of MEDLINE, EMBASE, and the ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-017-4086-3

    authors: Madenci AL,Li GZ,Weil BR,Zurakowski D,Kang PB,Weldon CB

    更新日期:2017-06-01 00:00:00

  • Colonic perforation in the first few hours of life associated with rhizomelic chondrodysplasia punctata.

    abstract::Rhizomelic chondrodysplasia punctata (RCP), a rare autosomal recessive disease characterized by a disorder of peroxisome metabolism, has been shown to affect multiple organ systems. A neonate presenting with a colonic perforation in the first few hours of life was subsequently diagnosed with RCP. A literature search r...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-005-1426-5

    authors: Fairbanks T,Emil S

    更新日期:2005-08-01 00:00:00

  • The frequency, significance, and management of a right aortic arch in association with esophageal atresia.

    abstract::An unrecognised right aortic arch (RAA) found at thoracotomy may complicate the repair of oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF). This paper analyses the patient characteristics, peri-operative management, and outcome of 16 infants with a RAA, and proposes management guidelines. Between 1948 an...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050505

    authors: Bowkett B,Beasley SW,Myers NA

    更新日期:1999-01-01 00:00:00

  • Surgical treatment of infantile achalasia: a case report and literature review.

    abstract::Allgrove syndrome is a rare genetic disorder typically manifested by alacrima, achalasia, and adrenal insufficiency, and is one of the rare causes of achalasia in infants. While the gold standard for achalasia treatment in adults is an esophageal myotomy with fundoplication, a standard treatment for infantile achalasi...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-014-3493-y

    authors: Li Y,Fallon SC,Helmrath MA,Gilger M,Brandt ML

    更新日期:2014-06-01 00:00:00

  • Atypical pulmonary sequestration causing respiratory distress in a 2-month-old male infant.

    abstract::Pulmonary sequestrations are non-functional masses of lung tissue lacking normal communication with the tracheobronchial tree and systemic-circulation-derived blood supply. The disconnection between the normal airway and pulmonary arterial supply prevents pulmonary sequestrations from participating in respiration whil...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-017-4072-9

    authors: Rossi JB

    更新日期:2017-07-01 00:00:00

  • Life-threatening respiratory distress in a neonate with a pericardial cyst.

    abstract::Our case report details the clinical course and management of a neonate with acute life-threatening respiratory distress presenting soon after birth. She needed intubation and ventilation. A pericardial cyst was diagnosed after a CT scan and 2D echo investigation. As a temporizing procedure the fluid was tapped and th...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-003-0970-0

    authors: Upadhyaya M,Jaffer M

    更新日期:2003-11-01 00:00:00

  • Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow's milk protein allergy?

    abstract:BACKGROUND/PURPOSE:To determine the frequency and characteristics of suspected cow's milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk. METHODS:A retrospective cohort study of 111 consecutive infants with gastroschisis. RESULTS:64 episodes suggesting non-IgE-mediated CMPA occurr...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-015-3664-5

    authors: Burge D,Drewett M,Hall N

    更新日期:2015-03-01 00:00:00

  • Non-operative treatment versus percutaneous drainage of pancreatic pseudocysts in children.

    abstract:PURPOSE:The objective of this study was to characterize the clinical course and outcomes of children with pancreatic pseudocysts that were initially treated non-operatively or with percutaneous drainage. METHODS:A retrospective review of children with pancreatic pseudocysts over a 12-year period was completed. Categor...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-012-3236-x

    authors: Russell KW,Barnhart DC,Madden J,Leeflang E,Jackson WD,Feola GP,Meyers RL,Scaife ER,Rollins MD

    更新日期:2013-03-01 00:00:00

  • Ductoplasty for an aberrant hepatic duct in a choledochal cyst.

    abstract::The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/BF01371914

    authors: Todani T,Watanabe Y,Toki A,Sato Y,Ogura K,Yamamoto S,Furuta Y

    更新日期:1997-01-01 00:00:00