Abstract：
BACKGROUND:The role of thymectomy in the treatment of juvenile myasthenia gravis (JMG) is poorly defined. The objective of this systematic review was to evaluate the effect of thymectomy on survival, disease severity, and peri-operative complications for patients with JMG. METHODS:A search of MEDLINE, EMBASE, and the Cochrane Library (1/1/2000-3/1/2016) identified all English language, human studies of thymectomy for JMG. The population was patients with JMG age ≤18 years who underwent thymectomy (comparator group was unexposed to thymectomy). Outcomes included survival, disease severity, and post-operative complications. Data extraction was performed by independent reviewers. RESULTS:Sixteen retrospective studies included 1131 participants with JMG and 488 (43%) underwent thymectomy. Post-operative improvement in JMG severity occurred for 77% (n = 376/488). Comparisons of thymectomy to non-operative management were mixed. Post-operative complications were poorly recorded. Power to compare surgical approaches was limited. Outcomes specific to antibodies, surgical pathology findings, severity of JMG, and timing of thymectomy were sparse. CONCLUSIONS:Existing data regarding thymectomy for JMG are limited and entirely retrospective. The majority of patients who underwent thymectomy had improvement in disease severity and post-operative complications were rare. Prospective, multicenter study of thymectomy for JMG is warranted.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Madenci AL,Li GZ,Weil BR,Zurakowski D,Kang PB,Weldon CBdoi
10.1007/s00383-017-4086-3subject
Has Abstractpub_date
2017-06-01 00:00:00pages
683-694issue
6eissn
0179-0358issn
1437-9813pii
10.1007/s00383-017-4086-3journal_volume
33pub_type
杂志文章,评审abstract：:Hirschsprung's disease (HD) in Down's syndrome (DS) patients is stated to have a worse outcome than HD alone. In our study we reviewed the immediate and long-term outcomes of these children and questioned whether DS should influence the operative management. Data were collected on all children with HD (including total...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1617-0
更新日期：2006-02-01 00:00:00
abstract：:Congenital pyloric atresia (CPA) is a very rare condition that was first described by Calder in 1749. Commonly, CPA occurs as an isolated lesion, which has an excellent prognosis, but it can also be seen in association with other malformations, which can have a negative impact on the final outcome. The medical records...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1903-0
更新日期：2007-06-01 00:00:00
abstract：:The majority of congenital diaphragmatic hernias (CDH) occur through the foramen of Bochdalek; herniation through the foramen of Morgagni (MH) is rare. Fifteen children (12 males and 3 females) with congenital MH (7 right, 3 left, 5 bilateral) were treated over a period of 15 years, comprising 11% of a total of 135 ch...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100653
更新日期：2002-03-01 00:00:00
abstract：:To determine the long-term outcome of congenital cystic adenomatoid malformation (CCAM), the records of all patients with CCAM treated in three Hungarian paediatric surgical centers between 1977 and 1996 were reviewed. Patients were followed for up to 20 years following diagnosis and treatment. In 20 patients CCAM was...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050593
更新日期：1999-07-01 00:00:00
abstract：:Non-operative management of gastroschisis also known as plastic closure (PC) has been described as an alternative to conventional primary operative closure (POC) or staged silo closure (SSC). The aim of this study was to compare these techniques in neonates with gastroschisis. A retrospective review of neonates with g...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2153-5
更新日期：2008-07-01 00:00:00
abstract：AIMS AND OBJECTIVES:Vascularized bio-engineered human dermo-epidermal skin substitutes (vascDESS) hold promise for treating burn patients, including those with severe full-thickness wounds. We have previously shown that vascDESS promote wound healing by enhanced influx of macrophages and granulocytes. Immediately follo...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4179-z
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:The clinical application of autologous tissue-engineered skin analogs is an important strategy to cover large skin defects. Investigating biological dynamics, such as reinnervation after transplantation, is essential to improve the quality of such skin analogs. Previously, we have examined that our skin substit...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3978-y
更新日期：2016-12-01 00:00:00
abstract：:Gastroesophageal reflux (GER) is common after repair of esophageal atresia with a distal tracheoesophageal fistula (EATOF). In a retrospective study we assessed whether early 18-h pH monitoring can predict the development of EATOF-associated gastroesophageal reflux. During 1980-1997, 90 consecutive patients had primar...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1270-z
更新日期：2004-09-01 00:00:00
abstract：:Coagulopathies associated with malignancies are not extremely rare, but are uncommonly associated with Wilms' tumour (WT). A 6-month-old female with a WT and an abnormal coagulation profile is reported. Due to the Coagulopathy and elevated D-dimers in the blood, surgery was deferred and chemotherapy was given, after w...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0853-9
更新日期：2003-06-01 00:00:00
abstract：:Obstruction of the ureterovesical junction is an uncommon but well-recognized complication of ureteral reimplantation that traditionally has been treated by surgical correction [1, 5-9]. We report our experience with antegrade balloon dilation (ABD) of these strictures in two children. Obstruction was confirmed by diu...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00626067
更新日期：1996-10-01 00:00:00
abstract：INTRODUCTION:No protocol exists for prophylaxis or therapeutic management of peripherally inserted central catheter (PICC) related deep venous thrombosis (DVT) in children. Currently, very few patients are provided prophylaxis for DVT. In this study, we analyzed our current practice of PICC placement to identify the fr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3259-y
更新日期：2013-05-01 00:00:00
abstract：:Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intest...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1035-0
更新日期：2003-12-01 00:00:00
abstract：:The Malone antegrade enema (MACE) and the caecostomy button (CB) are two methods of achieving colonic lavage in constipated children with faecal soiling. We reviewed our experience with the MACE and CB, aiming to compare results, complications, and outcomes. Between June 1998 and August 2002, 37 children (15 boys) und...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1220-9
更新日期：2004-07-01 00:00:00
abstract：:Congenital obstructive uropathy is associated with significant morbidity and mortality in the human neonate. The pathophysiology of congenital obstructive uropathy is poorly understood. There are very few experimental models of prenatal obstruction of the urinary tract, except in the fetal lamb or inbred rats. Prenata...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1322-4
更新日期：2005-03-01 00:00:00
abstract：:The successful management of faecal incontinence can dramatically improve the quality of life of affected children. The introduction of the non-refluxing, catheterisable appendico-caecostomy provides the opportunity to treat previously resistant patients. Over a 6-year period, 29 children had a Malone antegrade contin...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050342
更新日期：1998-07-01 00:00:00
abstract：:It is unknown whether noncomplicated acute appendicitis cause bacterial translocation. In this study, we aimed to test development of the bacterial translocation in the patients who were operated for acute appendicitis. In this prospective study, 10 control patients who underwent elective operations because of other r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1899-5
更新日期：2007-06-01 00:00:00
abstract：:Juvenile papillomatosis (JP) is a rare benign, proliferative breast tumor in children. We observed a 9-year-old girl with a large soft-tissue mass at the lower outer quadrant of the left breast. Ultrasonography showed an ill-defined, inhomogeneous mass with numerous small, hypoechoic areas. The tumor was completely ex...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000462
更新日期：2001-03-01 00:00:00
abstract：AIMS:The aim of this study was to assess the usefulness of PAS, β-catenin and Ki-67 in categorising hepatoblastomas (HBs) and their significance in predicting prognosis. In addition, we have also documented the various chemotherapy induced histologic changes in HBs. METHOD:In this retrospective observational study of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4115-2
更新日期：2017-09-01 00:00:00
abstract：AIM:To determine if follow-up by consultant pediatric surgeons (CPS) affects morbidity due to incarceration (INC) in children with indirect inguinal hernia (IH). METHODS:We educate parents so they can identify possible INC and advise them to attend our emergency department anytime for immediate review by on-call CPS. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-011-3005-2
更新日期：2012-01-01 00:00:00
abstract：:We describe the case of a 4-year-old boy with a unilateral right-sided Wilms tumor with stromal predominance and teratoid features, which was localized to the kidney and hence, was completely resected. The pediatric surgeon and pathologist, both should be aware of this rare appearance of nephroblastoma so as to avoid ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-009-2333-y
更新日期：2009-03-01 00:00:00
abstract：:To evaluate the efficacy of ultrasound (US) guided percutaneous sclerotherapy in the pediatric population, 14 hydatid liver cysts (HLC) in eight male patients whose ages ranged between 6 and 16 years (mean 9.9 years) were treated. The maximum diameter was 110 mm. Albendazole was administered orally to all patients for...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000356
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:Experience with male cloaca (MC), a single opening in perineum for passage of urine and meconeum is described. METHODS:Cases of MC were ambispectively studied, prospectively from July 2007 to April 2015 and retrospectively for last three decades. RESULTS:Seven cases of MC were identified, between the ages of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3738-4
更新日期：2015-08-01 00:00:00
abstract：:We present the case of a 10-year-old girl with biliary atresia in whom focal nodular hyperplasia (FNH) of the liver occurred following successful "Kasai" hepatic portoenterostomy at the age of 2 months. Her jaundice completely disappeared a few weeks after the operation. A 4-cm diameter liver tumor in segment IV was f...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-2090-8
更新日期：2008-05-01 00:00:00
abstract：UNLABELLED:Necrotizing enterocolitis (NEC) is a serious condition with a high morbidity and mortality commonly affecting premature babies. Data for the impact of the long-term disease burden in developing countries are limited although poor long-term outcome of surgically managed patients has been shown in terms of inc...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2583-8
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Pediatric surgeons and patient organisations agree that fewer centers for anorectal malformations with larger patient numbers are essential to reach better treatment. The European Union transacts a political process which aims to realize such centers of expertise for a multitude of rare diseases. All the cen...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3752-6
更新日期：2015-08-01 00:00:00
abstract：:Nine babies with pure oesophageal atresia were treated in our institution in the years 1979-1996. All received a feeding gastrostomy as their initial operation. After initiation of gastrostomy feeds seven (78%) developed gastric complications, including two posterior gastric perforations (one fatal). We propose that t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050640
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate the mid-term outcomes of single-stage modified anterior sagittal anorectoplasty (ASARP) for anorectal malformation with vestibular fistula. METHOD:Twenty-six patients with congenital imperforate anus and vestibular fistula underwent single-stage modified sphincter-saving ASARP betw...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3749-1
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Apparently superior result was observed after open Kasai portoenterostomy in infant with biliary atresia. Our institute stopped performing laparoscopic portoenterostomy since 2007. We aimed to investigate the outcome after reintroduction of open portoenterostomy. METHODS:27 non-syndromic infants underwent open...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3499-5
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:Tracheoesophageal fistula (TEF) is a bellwether for a country's ability to care for sick newborns. We aim to review the existing literature from low- and middle-income countries in regard to management of those newborns and the possible approaches to improve their outcomes. METHODS:A review of the existing Eng...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-020-04639-7
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:The aim of the present study was to review the complications and growth after proctocolectomy and ileal J-pouch anal anastomosis (IPAA) in pediatric ulcerative colitis (UC) patients receiving prolonged steroid therapy. PATIENTS AND METHODS:We experienced 209 patients with UC who received IPAA between September...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2577-6
更新日期：2010-04-01 00:00:00
