Abstract：
:Congenital obstructive uropathy is associated with significant morbidity and mortality in the human neonate. The pathophysiology of congenital obstructive uropathy is poorly understood. There are very few experimental models of prenatal obstruction of the urinary tract, except in the fetal lamb or inbred rats. Prenatal exposure to Adriamycin in a rat model leads to a spectrum of malformations including urinary tract anomalies. We hypothesized that Adriamycin administration during a particular time frame could yield a high incidence of urinary tract anomalies and therefore designed this study to investigate the rates of urinary tract anomalies at different windows of Adriamycin injection in rat embryos. Adriamycin (1.75 mg/kg) was administered intraperitoneally to pregnant rats at different times from days 6 to 10 of gestation. Control animals were given saline. Embryos recovered on gestational day 21 by cesarean section were examined for urinary tract anomalies, and malformations were noted. Sections were then processed for paraffin embedding, sectioned at 5 mum, and stained with hematoxylin and eosin for histological examination. Anomalies of the urinary tract occurred maximally following Adriamycin administration on days 7, 8, and 9 of gestation (91.6%) compared with 16% of controls. The most common urinary tract anomaly in the Adriamycin group was bilateral megaureters with a hypoplastic bladder (81%). Other anomalies included unilateral or bilateral ureterohydronephrosis with a normal-sized bladder, duplex kidney, and unilateral or bilateral renal agenesis. In conclusion, the critical embryologic window for the development of bilateral megaureters with a small bladder in the Adriamycin rat model occurs following Adriamycin administration on gestational days 7-9. This simple experimental model of bilateral megaureter may allow further research into the pathophysiology of this condition.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Mortell A,Fourcade L,Solari V,Puri Pdoi
10.1007/s00383-004-1322-4subject
Has Abstractpub_date
2005-03-01 00:00:00pages
212-6issue
3eissn
0179-0358issn
1437-9813journal_volume
21pub_type
杂志文章abstract：BACKGROUND:Cervicovaginal atresia is a rare Mullerian anomaly. The management of cervicovaginal atresia has evolved from historical recommendations of hysterectomy to various reconstructive procedures more recently. The latter carries a risk of significant morbidity and unknown fertility. We present our experience in t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3550-6
更新日期：2014-10-01 00:00:00
abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue tumour in children. This is the first time a facial RMS metastatic to the pancreas is reported. The patient was a 3-year-old boy with a symptomatic solitary pancreatic metastasis of a primary facial RMS, with already one relapse in a submental lymph node. Since thi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2539-z
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Retinoids are essential for fetal and lung development. Beta-carotene(BC) is the main dietary retinoid source and beta-carotene-15,15'-oxygenase-1 and 2 (Bcmo1,2) is the primary enzyme generating retinoid from BC in adult mammalian tissues. Placenta has a major role in the retinol homeostasis in fetal life: ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3621-8
更新日期：2015-01-01 00:00:00
abstract：:Ovarian involvement of acute lymphoblastic leukemia (ALL) without relapse in the bone marrow or other extramedullary site is rare. We report a case of ovarian relapse in a 13-year-old girl who was diagnosed with ALL at the age of 11. A complete remission was induced with the Children Cancer Group 1882 protocol for hig...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-008-2253-2
更新日期：2008-11-01 00:00:00
abstract：:Traditionally, open repair of esophageal atresia (EA) with tracheoesophageal fistula (TEF) required thoracotomy. Innovations in minimal access surgery have created a thoracoscopic technique resulting in violation of the pleural space. Most pediatric surgeons favor an extrapleural approach for open repair. We present a...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1366-0
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Variation exists in the diagnostic testing for gastroesophageal reflux (GER) in infants and in the application of surgical therapy. There has been an increase in antireflux surgery (ARS) since the development of laparoscopy but the outcomes in high-risk infants is unclear. This study examines the results of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4281-x
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The role of thymectomy in the treatment of juvenile myasthenia gravis (JMG) is poorly defined. The objective of this systematic review was to evaluate the effect of thymectomy on survival, disease severity, and peri-operative complications for patients with JMG. METHODS:A search of MEDLINE, EMBASE, and the ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-017-4086-3
更新日期：2017-06-01 00:00:00
abstract：:We examined immunohistochemically the expression and localisation of synapse-associated proteins, syntaxin (SNT) and synaptotagmin (STG) in the entire resected specimens of colon obtained at the time of pull-through operation from 15 patients with Hirschsprung's disease (HD) and 6 age-matched controls. Both antibodies...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050408
更新日期：1998-10-01 00:00:00
abstract：:Non-accidental trauma (NAT) represents a significant cause of morbidity and mortality in the pediatric population. The management of these patients often involves many care providers including the surgeon. Victims of NAT often present with multiple injuries and as such should be treated as trauma patients with complet...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-015-3688-x
更新日期：2015-07-01 00:00:00
abstract：:The successful management of faecal incontinence can dramatically improve the quality of life of affected children. The introduction of the non-refluxing, catheterisable appendico-caecostomy provides the opportunity to treat previously resistant patients. Over a 6-year period, 29 children had a Malone antegrade contin...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050342
更新日期：1998-07-01 00:00:00
abstract：:A case of an epigastric giant-cell fibroblastoma is reported in a 6-year-old girl who had undergone a bone-marrow transplant for severe combined immunodeficiency secondary to adenosine deaminase deficiency. A small subcutaneous nodule had been excised from the epigastrium at age 12 months. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0827-y
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency is associated with intestinal barrier dysfunction, which contributes to pathogenesis of acute intestinal injury in children. We aim to investigate the effects of vitamin D on intestinal injury in intestinal epithelial cells and organoids. METHODS:Lipopolysaccharide (LPS) was used to ind...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04586-y
更新日期：2019-12-01 00:00:00
abstract：:The embryogenesis of a previously unreported mesothelial pouch containing a Meckel's diverticulum is presented. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01076960
更新日期：1997-07-01 00:00:00
abstract：:Endoscopic holmium:yttrium-aluminum-garnet (Ho:YAG) laser incision is a new method applied in pediatric urology recent years. To evaluate its therapeutic efficacy on treating the pediatric patients with urethral strictures and urethral atresias, a retrospective study was performed from June 2001 to July 2005 in a tota...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1692-x
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Inguinal hernia repair is the most frequently performed surgical procedure in infants and children. Especially in premature infants, prevalence reaches up to 30% in coincidence with high rates of incarceration during the first year of life. These infants carry an increased risk of complications due to genera...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3590-y
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Voltage-gated potassium ion channels have long been implicated in gastrointestinal motility. Recent studies have highlighted the role of voltage-gated channel subfamily G member 3 (KCNG3) and 4 (KCNG4) genes in the electrical functioning of interstitial cells of Cajal and PDGFRα+ cells of the mouse colon. We de...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4394-2
更新日期：2019-02-01 00:00:00
abstract：:An infant born in the 34th week of gestation weighing 5,355 g with a massive sacrococcygeal (SC) tumor was delivered by elective cesarean section. An ultrasonographic examination showed solid and cystic components in the tumor. Resection was successfully undertaken with insertion of a Nélaton catheter into the rectum ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000451
更新日期：2001-03-01 00:00:00
abstract：:Nitrofen induces in rats diaphragmatic hernia (CDH) with heart and lung hypoplasia by a mechanism involving oxidation. The aim of this study was to examine if prenatal administration of the anti-oxidant agent vitamin E (VitE) prevents to some extent heart and lung hypoplasia. Pregnant rats received on E9.5 either 100 ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1005-6
更新日期：2003-07-01 00:00:00
abstract：INTRODUCTION:Management of oesophageal atresia (OA) and trachea-oesophageal fistula (TOF) in babies of low birth weight is challenging especially when associated with other anomalies. Birth weight of <1500 g has previously formed part of a classification system designed to predict outcome, alongside the cardiac status ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3851-4
更新日期：2016-06-01 00:00:00
abstract：:Multiple endocrine neoplasia (MEN) 2B is a hereditary syndrome including medullary thyroid carcinoma (MTC), pheochromocytoma, gastrointestinal (GI) disorders, marfanoid facies, and multiple ganglioneuromas. MTC is the major cause of mortality, and often appears during the 1st decade of life. RET proto-oncogene mutatio...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0824-1
更新日期：2002-09-01 00:00:00
abstract：:A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1875-0
更新日期：2007-08-01 00:00:00
abstract：:Malignant rhabdoid tumor (MRT) of the kidney is a rare pediatric tumor characterized by its aggressive nature and chemoresistance. Our patient had MRT of the right kidney with tumor thrombus in the renal vein, inferior vena cava, and right atrium. He developed transfusion-resistant hematuria. This was successfully con...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3260-5
更新日期：2013-05-01 00:00:00
abstract：:Primary lymphedema of the penis (PLP) is a rare disease. We report a case in a 2-year-old, uncircumcised boy where the uninvolved inner preputial skin was unfurled to cover the penile shaft. The uninvolved inner preputial skin is often elongated, and provides a suture-free cover of sufficient length for the small peni...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000487
更新日期：2001-03-01 00:00:00
abstract：PURPOSE:Reactive oxygen species (ROS) are thought to contribute to the pathogenesis of necrotizing enterocolitis (NEC). Mitochondria as a major source of intracellular ROS and apoptotic signaling during oxidative stress in NEC have not been investigated. We sought to determine: (1) the effects of oxidative stress on in...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2880-x
更新日期：2011-08-01 00:00:00
abstract：:In spite of advances in the treatment of childhood bladder and prostate rhabdomyosarcoma (RMS), the ability to detect minimal residual disease correlates imperfectly with the ultimate outcome. We report the long-term follow-up of a child with microscopic residual RMS after chemotherapy. The correct interpretation of t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830200017
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:Surgical repair of pectus excavatum (PE) in childhood is a well-established procedure. Previously used operative techniques to correct PE were largely based on the Ravitch technique. Since about 10 years, the minimally invasive repair (MIRPE) by Nuss is well established. Conservative treatment with the vacuum...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2843-7
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:Adhesive small bowel obstruction (ASBO) is one of the most important cause of postoperative morbidity in children who underwent abdominal surgery. Laparoscopic management for ASBO in pediatric patients has been reported. However, its safety and efficacy has not been evaluated in details. The aim of this study i...
journal_title：Pediatric surgery international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00383-017-4186-0
更新日期：2018-02-01 00:00:00
abstract：:The case of a 9-year-old girl with a Mycobacterium tuberculosis inflammatory myofibroblastic tumor (IMT) of the left lobe of the liver is reported. The tumor was surgically excised and had histological features diagnostic of IMT, a positive Ziehl-Nielsen staining for acid-fast bacilli and a positive polymerase chain r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-009-2361-7
更新日期：2009-05-01 00:00:00
abstract：:Non-operative management of gastroschisis also known as plastic closure (PC) has been described as an alternative to conventional primary operative closure (POC) or staged silo closure (SSC). The aim of this study was to compare these techniques in neonates with gastroschisis. A retrospective review of neonates with g...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2153-5
更新日期：2008-07-01 00:00:00
abstract：:Lipiodol, a stable iodine addition product of fatty ethyl esters derived from poppyseed oil, has been used as a vehicle for targeted cytotoxic or radiotherapeutic treatment in adults with unresectable hepatocellular carcinoma and in a few children with advanced hepatoblastoma (HB). Prolonged retention of lipiodol by t...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100004
更新日期：2001-11-01 00:00:00
