Abstract：
INTRODUCTION:It is an accepted fact that it is wise to start antiepileptic treatment with monotherapy, but 30% of patients do not respond to it or to several monotherapies; in that moment an association of two or more antiepileptic drugs is commonly utilised (the appearance of ten second-generation antiepileptic drugs on the market has not changed this scenario to any significant extent). Yet, on the other hand, the use of bitherapy in epilepsies that are usually resistant to treatment has been suggested as a interesting way to begin treatment. DEVELOPMENT:This article consists of three parts. In this first part we review the concept of rational combination therapy, the concept of how and when it should be used and the studies about associations of antiepileptic drugs conducted in animals and in humans. CONCLUSIONS:Although combination therapy is frequent as treatment for epilepsy, it is not always so obvious that it offers more benefits in terms of greater effectiveness with a lower, or at least equal, degree of toxicity. Few methodologically correct clinical trials have been conducted and recent reviews continue to consider that no controlled clinical trials have been carried out that confirm the benefits of combination therapy. This does not mean, however, that rational combination therapy is totally void of any kind of usefulness, but rather it stresses the fact that it offers a low level of evidence.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Armijo JA,Herranz JLsubject
Has Abstractpub_date
2007-07-16 00:00:00pages
95-109issue
2eissn
0210-0010issn
1576-6578pii
rn2007259journal_volume
45pub_type
杂志文章,评审abstract：:Restoration of blood flow is necessary when treating brain ischemia. However, except in very early cases, this is insufficient to prevent the cascade of mediators of cell damage unleashed by ischemia which, on the other hand, is boosted by the deleterious effects of reperfusion. We therefore consider adequate treatmen...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
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journal_title：Revista de neurologia
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journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.6910.2019221
更新日期：2019-11-16 00:00:00
abstract：INTRODUCTION:Necrosis of the basal ganglia (NBG) is an uncommon condition in childhood. Cases of NBG have been reported in connection with metabolic disorders, infections, degenerative conditions, intoxications, head injuries and hypoxic-ischemic encephalopathies. The commonest clinical features include alteration of c...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-05-16 00:00:00
abstract：INTRODUCTION:Visual phenomena can be symptoms of epileptic seizures, although with an uncertain clinical meaning and relationship with the epileptogenic focus. AIMS:To describe the clinical implications of visual epileptic seizures according to their signs and symptoms in adults. PATIENTS AND METHODS:Data were collec...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-02-16 00:00:00
abstract：INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
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更新日期：2015-05-16 00:00:00
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journal_title：Revista de neurologia
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更新日期：2018-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-11-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-16 00:00:00
abstract：INTRODUCTION:Face perception involves a broad network of connections between cortical and subcortical regions for the exchange and synchronization of information using white matter fibers. This precise communication system can be affected by the structures and the pathways that connect them. AIMS:To establish the neur...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-12-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-03-16 00:00:00
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journal_title：Revista de neurologia
pub_type：
doi：
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:Theories about consciousness are in an initial state of development. In the recent past, diverse theories have been proposed to explain the phenomenon of the consciousness using the Quantum Mechanics (QM) as a fundamental tool. Here, we criticize some of these theories in the light of the current knowledge in...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-07-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-10-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2005-04-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2014-01-16 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-06-16 00:00:00
abstract：INTRODUCTION AND AIMS:Trepanation is one of the earliest examples of a surgical procedure being carried out by human beings and was performed from the Neolithic period onwards in a large number of primitive cultures throughout the five continents. Trepanation and cranial deformation were both common in the pre-Columbin...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2004-05-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:The progress made in perinatal health care in recent years has changed the epidemiology of neurological diseases during the neonatal period. The reduction in neonatal mortality has been accompanied by an increasingly large number of patients suffering from disabling diseases or with a risk of suffering fro...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:The Minimental State Examination (MMSE), created in 1975 as a tool for briefly evaluating the patient's mental state, has been widely used and is the most frequently cited cognitive test on Medline, as well as being the one with the most versions in different languages (over 70). Through a review of the Medline databa...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2015-10-16 00:00:00
abstract：INTRODUCTION:Cavernous angiomas account for 5-13% of all vascular malformations. In 75% of cases they are situated in the posterior fossa and up to 30% are associated with abnormal venous drainage. The main complication is haemorrhage; the presence of a neurological focus without radiological evidence of bleeding is ve...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：INTRODUCTION:Non epileptic paroxysmal events (NEPE) are clinical disorders of usually sudden appearance, brief and originated by a cerebral disfunction of diverse causes with a common character to be no epileptic. DEVELOPMENT:The non epileptic paroxysmal events are more frequent than epileptic events. The 10% of the c...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
