Abstract:
PURPOSE:To determine minimum inhibitory concentration (MIC) of various anti-tuberculosis drugs for Mycobacterium avium complex (MAC) strains isolated from clinical samples. METHODS:Forty-nine human isolates of MAC were tested for susceptibility to nine chemotherapeutic agents. All isolates were from Indian patients suffering from chronic pulmonary mycobacteriosis. Drug susceptibility was performed both by agar dilution and MIC method. MIC values were analysed, both visually and by enzyme-linked immunosorbent assay reader. RESULTS:More than 40% of the MAC isolates were sensitive to ciprofloxacine (48.98%), amikacin (46.94%) and roxithromycin (42.86%) by the MIC method. In contrast, the isolates showed high degree of resistance to the first line antituberculosis drugs: only 28.6% were sensitive to rifampicine, 22.85% to isoniazid and ethambutol each and 36.7% were sensitive to streptomycin. In addition, 22.85% of the strains were sensitive to clofazimine and 34.7% to kanamycin. CONCLUSIONS:Results of the study confirm the suitability of the rapid broth micro dilution (MIC) method as a simple yet reliable method to assay for the drug susceptibility of nontuberculosis mycobacterium.
journal_name
Indian J Med Microbioljournal_title
Indian journal of medical microbiologyauthors
Venugopal D,Kumar S,Isa M,Bose Mdoi
10.4103/0255-0857.32716subject
Has Abstractpub_date
2007-04-01 00:00:00pages
115-20issue
2eissn
0255-0857issn
1998-3646journal_volume
25pub_type
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journal_title:Indian journal of medical microbiology
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doi:
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pub_type: 杂志文章
doi:
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journal_title:Indian journal of medical microbiology
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doi:10.4103/0255-0857.115229
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doi:10.4103/0255-0857.81801
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journal_title:Indian journal of medical microbiology
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journal_title:Indian journal of medical microbiology
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
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journal_title:Indian journal of medical microbiology
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更新日期:2008-07-01 00:00:00
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journal_title:Indian journal of medical microbiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00