Synaptosome behaviour is unaffected by weak pulsed electromagnetic fields.

Abstract:

:The present study examined the effect on rat cortical synaptosomes of a 2 h exposure to 50-Hz electromagnetic fields (EMFs) with a peak magnetic field of 2 mT. We measured modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intrasynaptosomal Ca(2+) concentration and free iron release. The O(2) consumption remained unvaried in exposed synaptosomes at about 2 nM O(2)/min/mg proteins; ATP production was also unchanged. The intrasynaptosomal Ca(2+) concentration decreased slowly and there was a slight, but non-significant, depolarisation of the synaptosomal membrane. Finally, the free iron release by synaptosomal suspensions, a useful predictor of neuro-developmental outcome, remained unchanged after EMF exposure. On the whole, our results indicate that the physiological behaviour of cortical synaptosomes is not affected by weak pulsed EMFs.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Aldinucci C,Carretta A,Maiorca S,Rossi V,Ciccoli L,Pessina GP

doi

10.1002/bem.20322

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

477-83

issue

6

eissn

0197-8462

issn

1521-186X

journal_volume

28

pub_type

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