Does direction of induced electric field or current provide a test of mechanism involved in nerve regeneration?

Abstract:

:We suggest an experimental comparison of two directions for applying the time-varying magnetic fields which have been found to speed spontaneous regeneration of injured peripheral nerves and in attempts to repair spinal cord injuries. Time-varying magnetic fields induce currents in a plane perpendicular to the magnetic field direction. The lower conductivity of the spinal cord's sheath (dura matter) or of the myelin sheath of peripheral nerves would seem to confine the induced electric fields and currents to the spinal cord or nerve itself. The proposed comparison could allow choosing between two possible modes of action of the fields: (1) Magnetically-induced electric fields or currents may be encouraging ion flow or otherwise helping enzyme, channel or other interactions at the cell membrane, as is thought to be the case in field stimulation of healing in bone. This mechanism should be independent of field direction. (2) Work in developing organisms and with fields applied to nerve cells in vitro has shown that neurite growth is guided parallel to both endogenous and external electric fields. This mechanism would be effective when induced electric fields are parallel, but not when they are perpendicular to the nerve. Any experimental test should seek to produce as close as possible to the same induced current intensity with both field directions. Possible confounding factors, as well as breakdowns in the assumptions of the simple model presented here, would have to be considered. This proposal was motivated by a recent report in which the authors listed a changed field direction as one of several possible reasons for an unsuccessful experiment.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Greenebaum B,Sisken BF

doi

10.1002/bem.20331

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

488-92

issue

6

eissn

0197-8462

issn

1521-186X

journal_volume

28

pub_type

杂志文章
  • Effects of static magnetic field on specific adenosine-5'- triphosphatase activities and bioelectrical and biomechanical properties in the rat diaphragm muscle.

    abstract::In this study, we aimed to clarify the effects of chronically applied static magnetic field (200 Gauss) on specific ATPase activities and bioelectrical and biomechanical responses in isolated rat diaphragm muscle. The mean activities of Na(+)-K+ ATPase and Ca2+ ATPase determined from the diaphragm homogenates were sig...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250160302

    authors: Iteğin M,Günay I,Loğoğlu G,Isbir T

    更新日期:1995-01-01 00:00:00

  • Chronically indwelling venous cannula and automatic blood sampling system for use with nonhuman primates exposed to 60 Hz electric and magnetic fields.

    abstract::An automated blood sampling system was developed for use with tethered baboons (Papio cynocephalus) during concurrent exposure to 60 Hz 30 kV/m electric fields and 0.1 mT (1.0 G) magnetic fields. The system was controlled by a FORTH-based microcomputer, which operated a pump, a fraction collector, and two pinch valves...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250160710

    authors: Rogers WR,Lucas JH,Mikiten BC,Smith HD,Orr JL

    更新日期:1995-01-01 00:00:00

  • Growth and developmental stability of Drosophila melanogaster in low frequency magnetic fields.

    abstract::Magnetic fields (60 Hz) of 1.5 and 80 microT caused a significant reduction in the weight of Drosophila melanogaster. Moreover, fruit flies in an 80 microT field showed lower developmental stability than either those in a 0 or 1.5 microT field. Developmental instability was measured by fluctuating asymmetry and freque...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Graham JH,Fletcher D,Tigue J,McDonald M

    更新日期:2000-09-01 00:00:00

  • Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats.

    abstract::Possible effects of 1439 MHz electromagnetic near field (EMF) exposure on the blood-brain barrier (BBB) were investigated using immature (4 weeks old) and young (10 weeks old) rats, equivalent in age to the time when the BBB development is completed and the young adult, respectively. Alteration of BBB related genes, s...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20138

    authors: Kuribayashi M,Wang J,Fujiwara O,Doi Y,Nabae K,Tamano S,Ogiso T,Asamoto M,Shirai T

    更新日期:2005-10-01 00:00:00

  • Effects of extremely-low-frequency magnetic fields on biological magnetite.

    abstract::Adair [Bioelectromagnetics 14:1-4, 1993] writes that "the effects of 60 Hz magnetic fields of 5 microT (50 mG) or less on biological structures holding magnetite (Fe3O4) are shown to be much smaller than those from thermal agitation; hence such interactions cannot be expected to be biologically significant." This conc...

    journal_title:Bioelectromagnetics

    pub_type: 评论,杂志文章

    doi:10.1002/bem.2250150308

    authors: Polk C

    更新日期:1994-01-01 00:00:00

  • Childhood cancer in relation to indicators of magnetic fields from ground current sources.

    abstract::This study examines childhood cancer risk in relation to certain factors likely to indicate magnetic field exposure from ground currents in the home. Substantial ground currents are most often found in homes having conductive plumbing, in which an uninterrupted metallic path in the water pipes and water main connects ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250160204

    authors: Wertheimer N,Savitz DA,Leeper E

    更新日期:1995-01-01 00:00:00

  • Response of perennial woody plants to seed treatment by electromagnetic field and low-temperature plasma.

    abstract::Radiofrequency (5.28 MHz) electromagnetic radiation and low-temperature plasma were applied as short-term (2-15 min) seed treatments to two perennial woody plant species, including Smirnov's rhododendron (Rhododendron smirnowii Trautv.) and black mulberry (Morus nigra L.). Potential effects were evaluated using germin...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22003

    authors: Mildaziene V,Pauzaite G,Malakauskiene A,Zukiene R,Nauciene Z,Filatova I,Azharonok V,Lyushkevich V

    更新日期:2016-12-01 00:00:00

  • Correlation between pulsed electromagnetic fields exposure time and cell proliferation increase in human osteosarcoma cell lines and human normal osteoblast cells in vitro.

    abstract::We have exposed cultured bone cells to a pulsed electromagnetic field (PEMF) for different times to find the minimal exposure time necessary to stimulate an increase of DNA synthesis. We used two different human osteosarcoma cell lines, TE-85 and MG-63, and human normal osteoblast cell (NHOC) obtained from surgical bo...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/(sici)1521-186x(1999)20:3<177::aid-bem4>3.

    authors: De Mattei M,Caruso A,Traina GC,Pezzetti F,Baroni T,Sollazzo V

    更新日期:1999-01-01 00:00:00

  • Amyotrophic lateral sclerosis and occupational exposure to electromagnetic fields.

    abstract::In an hypothesis-generating case-control study of amyotrophic lateral sclerosis, lifetime occupational histories were obtained. The patients (n = 28) were clinic based. The occupational exposure of interest in this report is electromagnetic fields (EMFs). This is the first and so far the only exposure analyzed in this...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/(sici)1521-186x(1997)18:1<28::aid-bem6>3.0

    authors: Davanipour Z,Sobel E,Bowman JD,Qian Z,Will AD

    更新日期:1997-01-01 00:00:00

  • Extremely low frequency electromagnetic field (ELF-EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patients.

    abstract::As a result of ischaemia/reperfusion, massive generation of reactive oxygen species occurs, followed by decreased activity of antioxidant enzymes. Extremely low frequency electromagnetic fields (ELF-EMF) can modulate oxidative stress, but there are no clinical antioxidant studies in brain stroke patients. The aim of o...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22055

    authors: Cichoń N,Bijak M,Miller E,Saluk J

    更新日期:2017-07-01 00:00:00

  • Measurement of low frequency magnetic fields from digital cellular telephones.

    abstract::Digital cellular telephones using the GSM (Global System for Mobile Communication) transmit information in bursts of microwaves. This pulsed transmitting mode causes the battery current and currents in the electronics of the apparatus to be pulsed. These pulsed currents produce corresponding pulsed magnetic fields nea...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Linde T,Mild KH

    更新日期:1997-01-01 00:00:00

  • Proflavin and microwave radiation: absence of a mutagenic interaction.

    abstract::The potential ability of radiofrequency electromagnetic radiation (RFR) in the microwave range to induce mutagenesis, chromosomal aberrations, and sister chromatid exchanges in mammalian cells is being explored in our laboratories. In addition, we have also been examining the ability of simultaneous exposure to RFR an...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250110206

    authors: Meltz ML,Eagan P,Erwin DN

    更新日期:1990-01-01 00:00:00

  • Cardiovascular and thermal responses in rats during 94 GHz irradiation.

    abstract::We investigated the thermal distribution and cardiovascular effects produced by sustained exposure of rats to 94 GHz radio-frequency electromagnetic radiation (RFR). Sixteen ketamine-anesthetized Sprague-Dawley rats were exposed individually at a power density of 75 mW/cm2 under far-field conditions in E orientation. ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Jauchem JR,Ryan KL,Frei MR

    更新日期:1999-01-01 00:00:00

  • Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation.

    abstract::Radio-frequency electromagnetic radiation (RFR) at 915 and 147 MHz, when sinusoidally amplitude modulated (AM) at 16 Hz, has been shown to enhance release of calcium ions from neuroblastoma cells in culture. The dose-response relation is unusual, consisting of two power-density "windows" in which enhanced efflux occur...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250130407

    authors: Dutta SK,Das K,Ghosh B,Blackman CF

    更新日期:1992-01-01 00:00:00

  • Description of a new computer wire coding method and its application to evaluate potential control selection bias in the Savitz et al. childhood cancer study.

    abstract::We developed a new computer wire coding method and then applied it to investigate the suggestion that control selection bias might explain the observed association between wire codes and childhood cancer made in the study conducted by Savitz et al. in the Denver area. The computer wire coding method used a geographic ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Ebi KL,Kheifets LI,Pearson RL,Wachtel H

    更新日期:2000-07-01 00:00:00

  • ELF magnetic fields induce internalization of gap junction protein connexin 43 in Chinese hamster lung cells.

    abstract::We have previously demonstrated that exposure of Chinese hamster lung (CHL) cells to 50 Hz magnetic fields (MFs) and/or 12-O-tetradecanoylphorbol-3-acetate (TPA)-inhibited gap junctional intercellular communication (GJIC). To explore and compare the mechanisms of GJIC inhibition induced by extremely low frequency (ELF...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10070

    authors: Zeng QL,Chiang H,Hu GL,Mao GG,Fu YT,Lu DQ

    更新日期:2003-02-01 00:00:00

  • Effect of nonionizing radiation on the Purkinje cells of the uvula in squirrel monkey cerebellum.

    abstract::Pregnant squirrel monkeys were exposed to 2450-MHz (CW) microwaves at an equivalent power density of 10 mW/cm2 (SAR 3.4 mW/g) for three hours daily in a cavity-cage module. The exposure began when pregnancy was determined by a hormonal method, and continued through of offspring's first 9.5 months. After irradiation, t...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250020305

    authors: Albert EN,Sherif MF,Papadopoulos NJ

    更新日期:1981-01-01 00:00:00

  • The remote sensing of mental stress from the electromagnetic reflection coefficient of human skin in the sub-THz range.

    abstract::Recent work has demonstrated that the reflection coefficient of human skin in the frequency range from 95 to 110 GHz (W band) mirrors the temporal relaxation of stress induced by physical exercise. In this work, we extend these findings to show that in the event of a subtle trigger to stress, such as mental activity, ...

    journal_title:Bioelectromagnetics

    pub_type: 临床试验,杂志文章

    doi:10.1002/bem.21698

    authors: Safrai E,Ishai PB,Caduff A,Puzenko A,Polsman A,Agranat AJ,Feldman Y

    更新日期:2012-07-01 00:00:00

  • Personal exposure to mobile communication networks and well-being in children--a statistical analysis based on a functional approach.

    abstract::The MobilEe-study was the first cross-sectional population-based study to investigate possible health effects of mobile communication networks on children using personal dosimetry. Exposure was assessed every second resulting in 86,400 measurements over 24 h for each participant. Therefore, a functional approach to an...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20477

    authors: Kühnlein A,Heumann C,Thomas S,Heinrich S,Radon K

    更新日期:2009-05-01 00:00:00

  • Effects of exposure to extremely low frequency magnetic fields on spermatogenesis in adult rats.

    abstract::The constant exposure of modern society to extremely low frequency magnetic fields (ELF-MF) has raised considerable concerns about the potential risks to male reproduction. However, the epidemiological and experimental data remain contradictory and inconclusive. In the present study, we investigated the effects of 50 ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.21816

    authors: Duan W,Liu C,Wu H,Chen C,Zhang T,Gao P,Luo X,Yu Z,Zhou Z

    更新日期:2014-01-01 00:00:00

  • 50 Hz magnetic field exposure alters onset of S-phase in normal human fibroblasts.

    abstract::This study was undertaken to investigate whether power frequency magnetic fields can affect the kinetics of cell cycle progression in exposed human cells. To achieve this, cultures of normal human fibroblasts were synchronised in the G(0) phase of the cell cycle and exposed to 50 Hz magnetic fields at a range of flux ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Cridland NA,Haylock RG,Saunders RD

    更新日期:1999-10-01 00:00:00

  • Rate of occurrence of transient magnetic field events in U.S. residences.

    abstract::Recent interest in the transient magnetic field events produced by electrical switching events in residential and occupational environments has been kindled by the possibility that these fields may explain observed associations between childhood cancer and wire codes. This paper reports the results of a study in which...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/(sici)1521-186x(200004)21:3<197::aid-bem7>

    authors: Kaune WT,Bracken TD,Senior RS,Rankin RF,Niple JC,Kavet R

    更新日期:2000-04-01 00:00:00

  • Chromosomal aberrations in lymphocytes of employees in transformer and generator production exposed to electromagnetic fields and mineral oil.

    abstract::The objective was to study the risk of cytogenetic damage among high voltage laboratory workers exposed to electromagnetic fields and mineral oil. This is a cross sectional study of 24 exposed and 24 matched controls in a Norwegian transformer factory. The exposure group included employees in the high voltage laborato...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.33

    authors: Skyberg K,Hansteen IL,Vistnes AI

    更新日期:2001-04-01 00:00:00

  • Do people understand IARC's 2B categorization of RF fields from cell phones?

    abstract::In May 2011, the International Agency on Cancer in Research (IARC) issued an official statement concluding that cell phone usage was "possibly carcinogenic to humans." There have been considerable doubts that non-experts and experts alike fully understood what IARC's categorization actually meant, as "possibly carcino...

    journal_title:Bioelectromagnetics

    pub_type: 信件

    doi:10.1002/bem.21851

    authors: Wiedemann PM,Boerner FU,Repacholi MH

    更新日期:2014-07-01 00:00:00

  • Gibberellins are involved in effect of near-null magnetic field on Arabidopsis flowering.

    abstract::We previously found that flowering of Arabidopsis was suppressed by near-null magnetic field, which was related to the modification of cryptochrome. To disclose the physiological mechanism of this effect, we detected gibberellin (GA) levels and expressions of GA biosynthetic and signaling genes in wild type Arabidopsi...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22004

    authors: Xu C,Yu Y,Zhang Y,Li Y,Wei S

    更新日期:2017-01-01 00:00:00

  • Endogenous ionic currents and DC electric fields in multicellular animal tissues.

    abstract::Through the use of the non-invasive vibrating probe technique for detecting extracellular ionic currents developed in 1974 [Jaffe and Nuccitelli: J Cell Biol 63:614-628, 1974], embryonic currents have been detected in a wide range of animal systems (recently reviewed in [Nuccitelli, Noninvasive Techniques in Cell Biol...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/bem.2250130714

    authors: Nuccitelli R

    更新日期:1992-01-01 00:00:00

  • Intracellular calcium activity in isolated bovine adrenal chromaffin cells in the presence and absence of 60 Hz magnetic fields.

    abstract::This study examined whether 60 Hz magnetic field (MF) exposure alters intracellular calcium levels ([Ca(2+)](i)) in isolated bovine adrenal chromaffin cells, a classic model of neural responses. [Ca(2+)](i) was monitored by fluorescence video imaging of cells loaded with the calcium indicator fluo-4 during exposures t...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10045

    authors: Craviso GL,Poss J,Lanctot C,Lundback SS,Chatterjee I,Publicover NG

    更新日期:2002-12-01 00:00:00

  • Lymphoma development of simultaneously combined exposure to two radiofrequency signals in AKR/J mice.

    abstract::There are public concerns regarding possible carcinogenic or cancer-promoting effects of radiofrequency electromagnetic fields (RF-EMFs) because of the extensive use of wireless mobile phones and other telecommunication devices in daily life. However, so far it is unclear if non-thermal exposure of single EMF exposure...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20655

    authors: Lee HJ,Jin YB,Lee JS,Choi SY,Kim TH,Pack JK,Choi HD,Kim N,Lee YS

    更新日期:2011-09-01 00:00:00

  • Optimal experimental design for in vitro studies with ELF magnetic fields.

    abstract::An experimental arrangement is described that maximized the dosimetric information that can be obtained during in vitro studies with ELF magnetic fields. The arrangement enables researchers to distinguish between a purely magnetic-field effect and one that also involves the electric fields and currents induced by the ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250110306

    authors: Misakian M,Kaune WT

    更新日期:1990-01-01 00:00:00

  • Morphological and electrophysiological changes produced by electrical stimulation in cultured neuroblastoma cells.

    abstract::Electric fields, which were equivalent to those generated by medical devices, were applied to cultured neuroblastoma cells (mouse and human) to test for morphological damage and to establish damage thresholds. Each of two methods of applying fields permitted flow of electrical current and minimized exposure of cells t...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250120505

    authors: Krauthamer V,Bekken M,Horowitz JL

    更新日期:1991-01-01 00:00:00