Abstract:
:This study examined whether 60 Hz magnetic field (MF) exposure alters intracellular calcium levels ([Ca(2+)](i)) in isolated bovine adrenal chromaffin cells, a classic model of neural responses. [Ca(2+)](i) was monitored by fluorescence video imaging of cells loaded with the calcium indicator fluo-4 during exposures to magnetic flux densities of 0.01, 0.1, 1.0, 1.4, or 2.0 mT. MFs generated by Helmholtz coils constructed from bifilar wire allowed both 60 Hz field and sham exposures. Following a 5 min monitoring period to establish baseline patterns, cells were subjected for 10 min to a 60 Hz MF, sham field or no field. Reference calcium responses and assessment of cell excitability were obtained by the sequential addition of the nicotinic cholinergic receptor agonist dimethylphenylpiperazinium (DMPP) and a depolarizing concentration of KCl. Throughout an 8 day culture period, cells exhibited spontaneous fluctuations in [Ca(2+)](i). Comparisons of the number of cells exhibiting transients, the number and types of calcium transients, as well as the time during monitoring when transients occurred showed no significant differences between MF exposed cells and either sham exposed or nonexposed cells. With respect to the percentage of cells responding to DMPP, differences between 1 and 2 mT exposed cells and both nonexposed and sham exposed cells reached statistical significance during the first day in culture. No statistically significant differences were observed for responses to KCl. In summary, our data indicate that [Ca(2+)](i) in chromaffin cells is unaffected by the specific 60 Hz MF intensities used in this study. On the other hand, plasma membrane nicotinic receptors may be affected in a manner that is important for ligand-receptor interactions.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Craviso GL,Poss J,Lanctot C,Lundback SS,Chatterjee I,Publicover NGdoi
10.1002/bem.10045subject
Has Abstractpub_date
2002-12-01 00:00:00pages
557-67issue
8eissn
0197-8462issn
1521-186Xjournal_volume
23pub_type
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20322
更新日期:2007-09-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/bem.22003
更新日期:2016-12-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21816
更新日期:2014-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20438
更新日期:2009-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 历史文章,杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(sici)1521-186x(1998)19:8<498::aid-bem8>3.
更新日期:1998-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250010203
更新日期:1980-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21779
更新日期:2013-07-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20658
更新日期:2011-09-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20098
更新日期:2005-05-01 00:00:00