Abstract:
:Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Sweetman LL,Ng YT,Kerrigan JFdoi
10.1177/0009922806295400subject
Has Abstractpub_date
2007-05-01 00:00:00pages
325-8issue
4eissn
0009-9228issn
1938-2707pii
46/4/325journal_volume
46pub_type
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