Abstract：
BACKGROUND:Previous studies have shown a single linear relationship between mean plasma glucose (MPG) and hemoglobin A(1c) (HbA(1c)). We examined the relationship in different treatment groups of patients with type 1 diabetes participating in the Diabetes Control and Complications Trial (DCCT). METHODS:Seven-point glucose profiles (premeal, postmeal, and bedtime) and HbA(1c) were measured quarterly during the DCCT. We studied measurements from (a) intensively treated patients at study commencement, (b) intensively treated patients after stabilization of their glycemia (from 6 months onward), and (c) conventionally treated patients from 6 months onward. Only complete glucose profile and HbA(1c) pairings were considered (n = 589, 11 483, and 11 855, respectively). RESULTS:From 6 months into the trial, conventionally treated patients had consistently higher MPG concentrations than intensively treated patients at any given HbA(1c) value (mean difference, 1.6 mmol/L at 7% HbA(1c), increasing to 2.8 mmol/L at 11% HbA(1c)). Similarly, at the same HbA(1c), the MPG of intensively treated patients at baseline was higher than in the same individuals after 6 months of intensive treatment (1.2 mmol/L difference at 7% HbA(1c), increasing to 4.6 mmol/L at 11% HbA(1c)). CONCLUSIONS:The relationship between MPG and HbA(1c) is not constant but differs depending on the glycemic control of the population being studied. Having lower mean glucose at the same HbA(1c) may help explain why intensive DCCT treatment appeared intrinsically linked to both increased hypoglycemia and decreased microvascular complications compared with conventional treatment. These findings may also have implications for expressing HbA(1c) as mean blood glucose equivalent.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Kilpatrick ES,Rigby AS,Atkin SLdoi
10.1373/clinchem.2006.079756subject
Has Abstractpub_date
2007-05-01 00:00:00pages
897-901issue
5eissn
0009-9147issn
1530-8561pii
clinchem.2006.079756journal_volume
53pub_type
杂志文章,随机对照试验abstract：:Market forces have dramatically influenced the environment in which healthcare is delivered, but these changes do not need to be interpreted negatively by community laboratorians. Only total vertical integration of laboratory medicine can control episode-of-care cost. Opportunities also exist for horizontal integratio...
journal_title：Clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：:We developed a radioimmunoassay with a gamma-emitting radioligand to measure androstenedione in human serum and in dried blood-spot samples from newborns. Antisera were raised in rabbits against androstenedione linked to bovine serum albumin at positions 3, 6, or 11 on the steroid nucleus. Radioligands were prepared b...
journal_title：Clinical chemistry
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doi：
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:Cerebrospinal fluid (CSF) tau is a common biomarker for Alzheimer disease (AD). Measurements of tau have historically been performed using immunoassays. Given the molecular diversity of tau in CSF, the selectivity of these immunoassays has often been questioned. Therefore, we aimed to develop an analytically...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：10.1373/clinchem.2013.216515
更新日期：2014-04-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:The topic of quality control often evokes prolific discussion among those whose business is its administration. Reliable methods for identifying mistakes must be developed in both the manufacture and use of test devices. Unit test devices are uncomplicated to run and provide quick results in a world where speed and si...
journal_title：Clinical chemistry
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更新日期：1997-05-01 00:00:00
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
更新日期：1993-08-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：1978-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1992-03-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1988-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1992-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1977-01-01 00:00:00
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更新日期：1984-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：10.1373/clinchem.2004.046995
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journal_title：Clinical chemistry
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doi：
更新日期：1986-01-01 00:00:00
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更新日期：1995-01-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：1984-08-01 00:00:00
