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Synthesis and biology of bis-xylosylated dihydroxynaphthalenes.

Abstract：

:The 10 analogous bis-xylosylated dihydroxynaphthalenes have been synthesized and their chemical and biological properties investigated. The yield of the xylosylation reactions can be correlated to the electrostatic potential, and thus to the nucleophilicity, for the oxygen atoms of the dihydroxynaphthalenes. The bis-xylosylated compounds were more stable compared to the mono-xylosylated ones. They initiate priming of glycosaminoglycan chains to less extent but the priming proceeds in two directions. Contrary to the mono-xylosylated analogs, the tested compounds did not show any antiproliferative properties.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Johnsson R,Mani K,Ellervik U

doi

10.1016/j.bmc.2007.02.020

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

2868-77

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00122-8

journal_volume

15

pub_type

杂志文章

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