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BH3-only proteins trigger cytochrome c release, but how?

Abstract：

:The mitochondrial apoptosis pathway has been neatly ordered. Mitochondrial apoptosis is governed by Bcl-2 family proteins, and their respective contributions determine the release of cytochrome c. It is clear that, among the Bcl-2 family, BH3-only proteins are the triggers: activation of BH3-only proteins by apoptotic stimuli initiates the process. BH3-only proteins cause cytochrome c release by activating Bax and/or Bak, and the anti-apoptotic group of Bcl-2-like proteins prevents this. However, it is curiously uncertain how BH3-only proteins activate Bax/Bak. Current models suggest that this is either through direct interaction--although this interaction is not detectable experimentally--or by the neutralisation of Bcl-2-like proteins. Here we discuss the context in which these models are placed and attempt to weigh the evidence.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Häcker G,Weber A

doi

10.1016/j.abb.2006.12.022

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

150-5

issue

2

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(06)00503-0

journal_volume

462

pub_type

杂志文章,评审

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