Enhanced analgesia with opioid antagonist administration.

Abstract:

BACKGROUND:Pain, not responsive to opioid analgesics, remains a problem for patients with chronic and cancer pain as well as their families, and clinicians. Opioid antagonists have various uses in pain and palliative care. Their use in the reversal of tolerance and hyperalgesia remains at the basic science level and has limited clinical exposure. OBJECTIVE:To improve symptom control and quality of life in patients with pain not responsive to opioid analgesics. DESIGN:Present three cases in which patients have undergone administration of opioid antagonists for the purpose of analgesia. METHODS:Patients on opioids analgesics received parenteral opioid antagonist, naloxone. Complete withdrawal under a sedative or conscious sedation was allowed and then the opioid at smaller doses was restarted and analgesia was observed. RESULTS:All patients had improved analgesia on a significantly lower dose of opioid analgesics. CONCLUSIONS:Only three patients who have received this procedure were presented yet all have responded positively to this procedure. Further research is needed to elucidate the mechanism and clinical relevance in the acute use of opioid antagonists.

journal_name

J Palliat Med

authors

Loitman JE

doi

10.1089/jpm.2006.9.1250

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1250-3

issue

6

eissn

1096-6218

issn

1557-7740

journal_volume

9

pub_type

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