Abstract:
BACKGROUND:Psychiatric research in the 1950s and 1960s showed potential for psychedelic medications to markedly alleviate depression and suffering associated with terminal illness. More recent published studies have demonstrated the safety and efficacy of psilocybin, MDMA, and ketamine when administered in a medically supervised and monitored approach. A single or brief series of sessions often results in substantial and sustained improvement among people with treatment-resistant depression and anxiety, including those with serious medical conditions. Need and Clinical Considerations: Palliative care clinicians occasionally encounter patients with emotional, existential, or spiritual suffering, which persists despite optimal existing treatments. Such suffering may rob people of a sense that life is worth living. Data from Oregon show that most terminally people who obtain prescriptions to intentionally end their lives are motivated by non-physical suffering. This paper overviews the history of this class of drugs and their therapeutic potential. Clinical cautions, adverse reactions, and important steps related to safe administration of psychedelics are presented, emphasizing careful patient screening, preparation, setting and supervision. CONCLUSION:Even with an expanding evidence base confirming safety and benefits, political, regulatory, and industry issues impose challenges to the legitimate use of psychedelics. The federal expanded access program and right-to-try laws in multiple states provide precendents for giving terminally ill patients access to medications that have not yet earned FDA approval. Given the prevalence of persistent suffering and growing acceptance of physician-hastened death as a medical response, it is time to revisit the legitimate therapeutic use of psychedelics.
journal_name
J Palliat Medjournal_title
Journal of palliative medicineauthors
Byock Idoi
10.1089/jpm.2017.0684subject
Has Abstractpub_date
2018-04-01 00:00:00pages
417-421issue
4eissn
1096-6218issn
1557-7740journal_volume
21pub_type
杂志文章,评审abstract:BACKGROUND:The evidence base to support palliative care clinical practice is inadequate and opportunities to improve the palliative care evidence base remain despite the field's rapid growth. OBJECTIVE:To examine current NIH funding of palliative medicine research, changes since our 2013 report, and trends since our 2...
journal_title:Journal of palliative medicine
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更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:We sought to develop and validate a novel palliative medicine needs assessment tool for patients with cancer in the emergency department. METHODS:An expert panel trained in palliative medicine and emergency medicine reviewed and adapted a general palliative medicine symptom assessment tool, the Needs at the ...
journal_title:Journal of palliative medicine
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journal_title:Journal of palliative medicine
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journal_title:Journal of palliative medicine
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journal_title:Journal of palliative medicine
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of palliative medicine
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
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journal_title:Journal of palliative medicine
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更新日期:2002-12-01 00:00:00
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journal_title:Journal of palliative medicine
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journal_title:Journal of palliative medicine
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更新日期:2015-08-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章,随机对照试验
doi:10.1089/jpm.2016.0046
更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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