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Scanning laser polarimetry with variable and enhanced corneal compensation in normal and glaucomatous eyes.

Abstract：

PURPOSE:To investigate whether correction for atypical birefringence pattern (ABP) using scanning laser polarimetry with enhanced corneal compensation (SLP-ECC) reduces the severity of ABP compared with variable corneal compensation (SLP-VCC) and improves the correlation with visual function. DESIGN:Prospective observational study. METHODS:Normal and glaucomatous eyes enrolled from four clinical sites underwent complete examination, automated perimetry, SLP-ECC, and SLP-VCC. Eyes were characterized in three groups based upon the typical scan score (TSS): normal birefringence pattern (NBP) was defined as TSS > or = 80, mild ABP as TSS 61 to 79, and moderate-severe ABP as TSS < or = 60. For each of four SLP parameters, the area under the ROC curve (AUROC) was calculated to compare the ability of SLP-ECC and SLP-VCC to discriminate between normal and glaucomatous eyes. RESULTS:Eighty-four normal volunteers and 45 glaucoma patients were enrolled. Mean TSS was significantly (P < .001) greater using SLP-ECC (98.0 +/- 6.6) compared with SLP-VCC (83.4 +/- 22.5). The frequency of moderate-severe ABP images was significantly (P < .001, McNemar test) higher using SLP-VCC (18 of 129, 14%) compared with SLP-ECC (one of 129, 0.8%). Two SLP-ECC parameters (temporal superior nasal inferior temporal [TSNIT] average and inferior average) had significantly (P = .01, P < .001) higher correlation (r = .45, r = .50, respectively) with MD compared with SLP-VCC (r = .34, r = .37). Among eyes with moderate-severe ABP (n = 18), inferior average obtained using SLP-ECC had significantly (P = .03) greater AUROC (0.91 +/- 0.07) compared with SLP-VCC (0.78 +/- 0.11). CONCLUSIONS:SLP-ECC significantly reduces the frequency and severity of ABP compared with SLP-VCC and improves the correlation between RNFL measures and visual function.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Sehi M,Guaqueta DC,Feuer WJ,Greenfield DS,Advanced Imaging in Glaucoma Study Group.

doi

10.1016/j.ajo.2006.09.049

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

272-9

issue

2

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(06)01103-2

journal_volume

143

pub_type

杂志文章,多中心研究

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