Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects.

Abstract:

:The bacterium Lactobacillus plantarum PH04 was isolated from infant feces and tested positive for bile/acid tolerance and bile salt hydrolase activity. It was evaluated as a potential probiotic with cholesterol-lowering effect. Bile salt hydrolase activity was nine times greater in stationary phase than in exponential phase cells and increased when the cells were exposed to conjugated bile salts. L. plantarum PH04 was resistant to seven of nine antibiotics tested and did not produce beta-glucuronidase. L. plantarum PH04 was fed to hypercholesterolemic mice at numbers of 10(7) CFU per mouse per day for 14 days. Compared with a control group, the serum cholesterol and triglycerides were respectively 7 and 10% lower in the group fed L. plantarum PH04, and fecal lactic acid bacteria increased while no any significant differences (P<0.05) in body weight, visceral weigh index or bacteria translocation between two groups were observed. The results indicated that L. plantarum PH04 might be effective as a probiotic with cholesterol-lowering activities.

journal_name

Int J Food Microbiol

authors

Nguyen TD,Kang JH,Lee MS

doi

10.1016/j.ijfoodmicro.2006.08.015

subject

Has Abstract

pub_date

2007-02-15 00:00:00

pages

358-61

issue

3

eissn

0168-1605

issn

1879-3460

pii

S0168-1605(06)00538-1

journal_volume

113

pub_type

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