Abstract:
:The bacterium Lactobacillus plantarum PH04 was isolated from infant feces and tested positive for bile/acid tolerance and bile salt hydrolase activity. It was evaluated as a potential probiotic with cholesterol-lowering effect. Bile salt hydrolase activity was nine times greater in stationary phase than in exponential phase cells and increased when the cells were exposed to conjugated bile salts. L. plantarum PH04 was resistant to seven of nine antibiotics tested and did not produce beta-glucuronidase. L. plantarum PH04 was fed to hypercholesterolemic mice at numbers of 10(7) CFU per mouse per day for 14 days. Compared with a control group, the serum cholesterol and triglycerides were respectively 7 and 10% lower in the group fed L. plantarum PH04, and fecal lactic acid bacteria increased while no any significant differences (P<0.05) in body weight, visceral weigh index or bacteria translocation between two groups were observed. The results indicated that L. plantarum PH04 might be effective as a probiotic with cholesterol-lowering activities.
journal_name
Int J Food Microbioljournal_title
International journal of food microbiologyauthors
Nguyen TD,Kang JH,Lee MSdoi
10.1016/j.ijfoodmicro.2006.08.015subject
Has Abstractpub_date
2007-02-15 00:00:00pages
358-61issue
3eissn
0168-1605issn
1879-3460pii
S0168-1605(06)00538-1journal_volume
113pub_type
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journal_title:International journal of food microbiology
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journal_title:International journal of food microbiology
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journal_title:International journal of food microbiology
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journal_title:International journal of food microbiology
pub_type: 杂志文章
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pub_type: 杂志文章
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