Chronic pancreatitis.

Abstract:

:In the past year, numerous important papers were published on chronic pancreatitis, its causes, and its diagnosis; the cause of fibrosis; and pain in pancreatic cancer. More than 750 mutations have been described in the cystic fibrosis transmembrane regulator (CFTR) gene. Some mutations cause relatively mild reductions in CFTR function and may lead to disease in one organ without clinical involvement of other organs. Two groups of investigators recently reported that "idiopathic" chronic pancreatitis may be the sole manifestation of some CFTR mutations. Some recent reports may enhance our understanding of pancreatic fibrogenesis and may lead to therapies for painful chronic pancreatitis. Pancreatic stellate cells are vitamin A-containing cells that resemble hepatic stellate cells and were recently isolated from rat and human pancreas. They respond to inflammatory cytokines by producing collagen. Two studies show that endoscopic ultrasonography (EUS) correlates well with endoscopic retrograde cholangiopancreatography in moderate to severe chronic pancreatitis. However, in patients who have a few nondiagnostic abnormalities on EUS, these results have poor correlation with the results of endoscopic retrograde cholangiopancreatography and the secretin test. The clinical significance of these abnormalities is unclear, and the diagnosis of chronic pancreatitis should not be based on EUS findings alone. Painful chronic pancreatitis is a complex and difficult management problem. A recent study of alcoholic chronic pancreatitis suggests that the best predictors of pain relief are an intermittent pattern of pain and the presence of surgically correctable complications (eg, pseudocysts or biliary obstruction). An American Gastroenterological Association technical review of painful chronic pancreatitis emphasized the lack of controlled studies supporting any form of therapy. Further evidence that longstanding chronic pancreatitis is a premalignant condition has been provided by recent epidemiologic, pathologic, and molecular biology studies.

authors

Chari ST,Dimagno EP

doi

10.1097/00001574-199909000-00005

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

398-403

issue

5

eissn

0267-1379

issn

1531-7056

pii

00001574-199909000-00005

journal_volume

15

pub_type

杂志文章
  • New advances in pancreatic imaging.

    abstract:PURPOSE OF REVIEW:Exciting new developments and applications of imaging techniques in pancreatic diseases have emerged. This review discusses these new advances and how they are improving our ability to diagnose malignancies and inflammatory lesions, to grade severity of pancreatitis, and to stage pancreatic cancer acc...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000174223.74783.1b

    authors: Kwon RS,Brugge WR

    更新日期:2005-09-01 00:00:00

  • Bile acid disease: the emerging epidemic.

    abstract:PURPOSE OF REVIEW:Our objective was to review advances in bile acids in health and disease published in the last 2 years. Bile acid diarrhea (BAD) is recognized as a common cause of chronic diarrhea, and its recognition has been facilitated by development of new screening tests. RECENT FINDINGS:Primary BAD can account...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000344

    authors: Oduyebo I,Camilleri M

    更新日期:2017-05-01 00:00:00

  • Autoimmune liver disease.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review studies that improve the diagnosis and treatment of autoimmune hepatitis and suggest new drug and molecular interventions. RECENT FINDINGS:Elderly patients have an indolent but aggressive disease that responds well to corticosteroid therapy. Variant syndromes are ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328034f234

    authors: Czaja AJ

    更新日期:2007-05-01 00:00:00

  • Portal hypertension.

    abstract:PURPOSE OF REVIEW:Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to port...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000218962.93806.9a

    authors: Garcia-Tsao G

    更新日期:2006-05-01 00:00:00

  • Adverse effects of proton pump inhibitor drugs: clues and conclusions.

    abstract:PURPOSE OF REVIEW:To review evidence relating to the strength of associations that have appeared in largely observational studies, between high-dose or long-term use of proton pump inhibitor drugs and certain possibly attributable side-effects, which emerge from studies confounded by other variables. In retrospective s...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32833ea9d9

    authors: McCarthy DM

    更新日期:2010-11-01 00:00:00

  • JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways.

    abstract:PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Niv Y,Goel A,Boland CR

    更新日期:2005-01-01 00:00:00

  • Chronic unexplained diarrhea: a logical and cost-effective approach to assessment.

    abstract:PURPOSE OF REVIEW:The workup of chronic unexplained diarrhea can be equally frustrating for care providers and patients. It carries a physical, financial, and social toll. In this review we provide a sensible approach to evaluating and managing chronic diarrhea. RECENT FINDINGS:Bile acid diarrhea is becoming increasin...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000232

    authors: Dosanjh G,Pardi DS

    更新日期:2016-01-01 00:00:00

  • Parasitic infections of the gastrointestinal tract.

    abstract::Intestinal parasites continue to be a significant health problem in both developed and developing countries. In developed countries, protozoans are more commonly the cause of gastrointestinal infections than are helminths. Some protozoan parasites have stages in which, in addition to being resistant to chemicals used ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200301000-00005

    authors: Harp JA

    更新日期:2003-01-01 00:00:00

  • Acute nonvariceal upper gastrointestinal bleeding.

    abstract:PURPOSE OF REVIEW:To review recent literature (2009-2010) on acute nonvariceal upper gastrointestinal hemorrhage. RECENT FINDINGS:There is a decreasing trend in the incidence and hospitalization for acute nonvariceal upper gastrointestinal hemorrhage worldwide, with significant improvement in rebleeding and mortality....

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32833d1746

    authors: Chiu PW,Sung JJ

    更新日期:2010-09-01 00:00:00

  • Small bowel ulcers: when is it not inflammatory bowel disease ?

    abstract:PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000522

    authors: Keuchel M,Kurniawan N,Baltes P

    更新日期:2019-05-01 00:00:00

  • Pouchitis: lessons for inflammatory bowel disease.

    abstract:PURPOSE OF REVIEW:One of the significant limitations to the investigation of inflammatory bowel disease (IBD) in humans is the impossibility of studying this condition from the beginning of the disease process to understand the individual contribution of the various microbiological and immunological components to its p...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32832b36eb

    authors: Wu H,Shen B

    更新日期:2009-07-01 00:00:00

  • Pathology of the liver.

    abstract::Traditional anatomic pathology studies and molecular investigations both contributed to the breadth of current information in the field of liver pathology this year. Techniques such as reverse transcription polymerase chain reaction can identify recurrence of hepatitis C virus infection in the liver as early as 5 days...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200105000-00002

    authors: Lefkowitch JH

    更新日期:2001-05-01 00:00:00

  • Pancreatic surgery.

    abstract:PURPOSE OF REVIEW:To summarize published research on pancreatic surgery over the past year. RECENT FINDINGS:Improvements in the treatment of patients with acute gallstone pancreatitis with regards to the timing of ERCP and cholecystectomy as well as management of pancreatic pseudocysts have been reported. It is often ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32833d1174

    authors: Donahue TR,Reber HA

    更新日期:2010-09-01 00:00:00

  • Potential of multiomics technology in precision medicine.

    abstract:PURPOSE OF REVIEW:The 'precision medicine' refers to the generation of identification and classification criteria for advanced taxonomy of patients, exploiting advanced models to infer optimized clinical decisions for each disease phenotype. RECENT FINDINGS:The current article reviews new advances in the past 18 month...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000589

    authors: Putignani L,Gasbarrini A,Dallapiccola B

    更新日期:2019-11-01 00:00:00

  • The management of the hospitalized ulcerative colitis patient: the medical-surgical conundrum.

    abstract:PURPOSE OF REVIEW:In this review article, we address emerging evidence for the medical and surgical treatment of the hospitalized patient with ulcerative colitis. RECENT FINDINGS:Ulcerative colitis is a chronic inflammatory disease involving the colon and rectum. About one-fifth of patients will be hospitalized from u...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000637

    authors: Levy LC,Coburn ES,Choi S,Holubar SD

    更新日期:2020-07-01 00:00:00

  • Colonoscopy: new approaches to better outcomes.

    abstract:PURPOSE OF REVIEW:Prevention of colorectal cancer relies on the detection and removal of colorectal neoplasia. Recent advances in mucosal imaging and inspection techniques have increased the detection of small and diminutive colorectal polyps with unknown clinical impact. The ability to accurately predict whether a pol...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32834ddab9

    authors: Coe SG,Wallace MB

    更新日期:2012-01-01 00:00:00

  • Prevention of catheter-related blood stream infections in children with intestinal failure.

    abstract:PURPOSE OF REVIEW:Catheter-related bloodstream infections (CRBSIs) account for a major source of morbidity in children with intestinal failure. Many of these patients require long-term central venous access, placing them at significant risk for these infections. The purpose of this review is to highlight the most curre...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328358e268

    authors: Piper HG,Wales PW

    更新日期:2013-01-01 00:00:00

  • Obesity pharmacology: past, present, and future.

    abstract::Over the past several years, the pharmacologic treatment of obesity has undergone changes in safety, efficacy, and therapeutic targeting. The prevalence of cardiac valvulopathy associated with treatment with phentermine, fenfluramine, and dexfenfluramine is now becoming clarified with the publication of longer-term st...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200203000-00011

    authors: Kushner RF,Manzano H

    更新日期:2002-03-01 00:00:00

  • Probiotics as prevention and treatment for diarrhea.

    abstract:PURPOSE OF REVIEW:To critically appraise evidence on probiotic use for prevention and treatment of diarrhea in children and adults. RECENT FINDINGS:Several randomized controlled trials and meta-analyses suggested that probiotics are effective in primary and secondary prevention of gastroenteritis and its treatment. Se...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32831b4455

    authors: Guarino A,Lo Vecchio A,Canani RB

    更新日期:2009-01-01 00:00:00

  • Flag in the crossroads: flagellin modulates innate and adaptive immunity.

    abstract:PURPOSE OF REVIEW:To consider observations suggesting that the bacterial protein flagellin, the primary structural component of flagella, plays a major role in mediating gut inflammation associated with infection by enteric pathogens and in inflammatory bowel disease. RECENT FINDINGS:Biochemical dissection of an in-vi...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000194791.59337.28

    authors: Gewirtz AT

    更新日期:2006-01-01 00:00:00

  • The dark side of the colon: current issues surrounding the significance, prevalence, detection, diagnosis and management of serrated polyps.

    abstract:PURPOSE OF REVIEW:Hyperplastic polyps, once considered to have no malignant potential, are now recognized to be part of a larger group of polyps known as serrated polyps. Serrated polyps can progress to CRC through an epigenetic pathway known as CpG Island Methylator Phenotype (CIMP), characterized by hypermethylation ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000495

    authors: Lindholm CR,Anderson JC,Srivastava A

    更新日期:2019-01-01 00:00:00

  • Utility of the Citrobacter rodentium infection model in laboratory mice.

    abstract:PURPOSE OF REVIEW:There have been considerable advances in our understanding of the molecular pathogenesis of enteropathogenic Escherichia coli and enterohemorrhagic E. coli infection. Given the difficulty of infecting laboratory mice with these diarrhea-causing pathogens, a growing number of studies have found the mur...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0b013e3282f2b0fb

    authors: Borenshtein D,McBee ME,Schauer DB

    更新日期:2008-01-01 00:00:00

  • Endoscopic management of biliary disease.

    abstract::Therapeutic biliary endoscopy continues to evolve. Key articles this year primarily involve biliary stenting and biliary stone removal, the two important maneuvers available to the biliary endoscopist. The issues addressed in this review include follow-up after the use of multiple stents for benign strictures, unilate...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200205000-00013

    authors: Barnett JL

    更新日期:2002-05-01 00:00:00

  • Molecular signatures for the dynamic process of establishing intestinal host-microbial homeostasis: potential for disease diagnostics?

    abstract:PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328365d365

    authors: El Aidy S,Kleerebezem M

    更新日期:2013-11-01 00:00:00

  • Endoscopic resection of early gastric cancer: the Japanese perspective.

    abstract:PURPOSE OF REVIEW:To examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer. RECENT FINDINGS:Endoscopic mucosal resection of early gastric cancer with no risk of lymph node metastasis has been a standard technique in Japan and is increasingly becoming accepted and re...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000239873.06243.00

    authors: Gotoda T

    更新日期:2006-09-01 00:00:00

  • Cryotherapy for Barrett's esophagus and esophageal cancer.

    abstract:PURPOSE OF REVIEW:To summarize the recent literature on endoscopic spray cryotherapy for the treatment of Barrett's esophagus and esophageal cancer. RECENT FINDINGS:Endoscopic spray cryotherapy is a relatively new ablative modality for the treatment of gastrointestinal diseases. Spray cryotherapy rapidly cools tissues...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328347bae8

    authors: Greenwald BD,Dumot JA

    更新日期:2011-07-01 00:00:00

  • Rotavirus vaccines and intussusception risk.

    abstract:PURPOSE OF REVIEW:Rotavirus infection is the leading cause of severe dehydrating gastroenteritis, responsible for an estimated 440,000 deaths per year in children less than 5 years of age worldwide. There was great optimism when the first rotavirus vaccine was licensed in the United States in July 1998 (rhesus rotaviru...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Bines JE

    更新日期:2005-01-01 00:00:00

  • Role of microbiota in postnatal maturation of intestinal T-cell responses.

    abstract:PURPOSE OF REVIEW:Taking advantage of their rapid growth and capacity for continuous genetic adaptation, prokaryotes have colonized all possible ecological environments on earth, including the body surfaces of eukaryotes and their gastrointestinal tract. The mammalian gut contains a complex community of 10 bacteria wit...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32834bb82b

    authors: Gaboriau-Routhiau V,Lécuyer E,Cerf-Bensussan N

    更新日期:2011-10-01 00:00:00

  • Pathogenesis of inflammatory bowel disease.

    abstract::In spite of expanding knowledge of cellular and molecular mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. The link between the environment and IBD is still circumstantial, but definite progress is occurring in defining genetic susceptibility loci...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199907000-00003

    authors: Katz JA,Itoh J,Fiocchi C

    更新日期:1999-07-01 00:00:00

  • Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018?

    abstract:PURPOSE OF REVIEW:To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS:The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing tha...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000455

    authors: Hyun JJ,Kozarek RA

    更新日期:2018-09-01 00:00:00