Potential of multiomics technology in precision medicine.

abstract：:The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...

journal_title：Current opinion in gastroenterology

authors： Katz PO

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To consider observations suggesting that the bacterial protein flagellin, the primary structural component of flagella, plays a major role in mediating gut inflammation associated with infection by enteric pathogens and in inflammatory bowel disease. RECENT FINDINGS:Biochemical dissection of an in-vi...

journal_title：Current opinion in gastroenterology

authors： Gewirtz AT

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of allergic diseases continues to rise globally in developed countries. Since the initial proposal of the hygiene hypothesis, there has been increasing evidence to suggest that the intestinal microbiota, particularly during early infancy, plays a critical role in regulating immune respo...

journal_title：Current opinion in gastroenterology

authors： Russell SL,Finlay BB

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Taking advantage of their rapid growth and capacity for continuous genetic adaptation, prokaryotes have colonized all possible ecological environments on earth, including the body surfaces of eukaryotes and their gastrointestinal tract. The mammalian gut contains a complex community of 10 bacteria wit...

journal_title：Current opinion in gastroenterology

authors： Gaboriau-Routhiau V,Lécuyer E,Cerf-Bensussan N

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to port...

journal_title：Current opinion in gastroenterology

authors： Garcia-Tsao G

更新日期：2006-05-01 00:00:00

abstract：:Advances in cellular and molecular biology of extrahepatic cholangiocarcinoma and gallbladder adenocarcinoma are providing innovative means for the diagnosis and treatment of biliary tract cancer. Similarly, refinements in noninvasive studies--including helical computed tomography, magnetic resonance cholangiopancreat...

journal_title：Current opinion in gastroenterology

authors： Abdalla EK,Vauthey JN

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature on endoscopic spray cryotherapy for the treatment of Barrett's esophagus and esophageal cancer. RECENT FINDINGS:Endoscopic spray cryotherapy is a relatively new ablative modality for the treatment of gastrointestinal diseases. Spray cryotherapy rapidly cools tissues...

journal_title：Current opinion in gastroenterology

authors： Greenwald BD,Dumot JA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal is to review the most recent literature about biosimilars in inflammatory bowel disease (IBD), with emphasis on controversial regulatory issues. RECENT FINDINGS:Although biosimilars have been in use in Europe since 2005, the recent approval of CT-P13 (Remsima, Inflectra), a biosimilar of the...

journal_title：Current opinion in gastroenterology

authors： Gomollón F

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory bowel disease commonly affects women during the childbearing years, and young couples are often concerned about the potential effects of inflammatory bowel disease on fertility, pregnancy, and the fetus. This review will critically consider advances over the past 2 years in our knowledge ...

journal_title：Current opinion in gastroenterology

authors： Katz JA

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Endoscopic approaches to obesity may help fulfill the unmet need of over half the US adult population who would benefit from therapy for obesity but are not receiving it. Endoluminal approaches have the potential to be more efficacious than antiobesity medications and have a lower risk-cost profile co...

journal_title：Current opinion in gastroenterology

authors： Kumbhari V,Oberbach A,Nimgaonkar A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The composition of activated adipose tissue with adipocytes secreting a broad spectrum of immune-modulatory adipokines next to adipose tissue-derived stromal cells and professional immune effector cells in the visceral fat creates a complex network of inflammatory processes shaping local immune respon...

journal_title：Current opinion in gastroenterology

authors： Paeschke A,Erben U,Kredel LI,Kühl AA,Siegmund B

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review studies that improve the diagnosis and treatment of autoimmune hepatitis and suggest new drug and molecular interventions. RECENT FINDINGS:Elderly patients have an indolent but aggressive disease that responds well to corticosteroid therapy. Variant syndromes are ...

journal_title：Current opinion in gastroenterology

authors： Czaja AJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent investigations into the regulation of pancreatic acinar cell function have led to a more detailed understanding of the mechanisms regulating digestive enzyme synthesis and secretion. This review identifies and puts into context those articles which further our understanding in this area. RECEN...

journal_title：Current opinion in gastroenterology

authors： Williams JA

更新日期：2006-09-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) affects many patients and has a negative effect on quality of life. Along with the increasing prevalence of GERD is an increase in GERD-related complications, including Barrett esophagus and esophageal adenocarcinoma. The past year has yielded new insights into the pathophysiolog...

journal_title：Current opinion in gastroenterology

authors： Sifrim D,Zerbib F

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Recently, a new class of intracellular pattern recognition receptors belonging to the family of nucleotide binding and oligomerization domain (NOD)-like receptors that includes NOD1, NOD2 and IPAF has been described. These proteins are involved in recognizing bacterial components or their degradation ...

journal_title：Current opinion in gastroenterology

authors： Rescigno M,Nieuwenhuis EE

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Even though recent accumulated data can help to understand fundamental molecular mechanisms of progression of cholangiocarcinoma (CCA), its incidence and mortality still keep increasing worldwide with poor prognosis. As appropriate animal disease models are critical to fill the gap between the finding...

journal_title：Current opinion in gastroenterology

authors： Ko KS,Peng J,Yang H

更新日期：2013-05-01 00:00:00

abstract：:This year's review has been divided into five sections: The first describes the natural history of drug-induced liver disease, the second discusses the issue of placebo-related increases in liver-associated enzymes, the third describes agents newly reported to cause hepatic injury, the fourth discusses new reports of ...

journal_title：Current opinion in gastroenterology

authors： Mayoral W,Lewis JH

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hereditary liver diseases resulting in copper and iron overload may cause significant morbidity and mortality if not diagnosed and treated early. The goal of this review is to highlight the key publications on genetics, diagnosis and management of hemochromatosis and Wilson disease over the past 18 mo...

journal_title：Current opinion in gastroenterology

authors： Maxwell KL,Kowdley KV

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cholangiocarcinoma (CCA) are heterogeneous tumors that arise from the malignant transformation of cholangiocytes along the biliary tree. CCA heterogeneity occurs at multiple levels and results in resistance to therapy and poor prognosis. Here, we review the molecular classification of CCA by focusing ...

journal_title：Current opinion in gastroenterology

authors： Louis C,Papoutsoglou P,Coulouarn C

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Ampullary tumors, usually adenomas, are often encountered during endoscopic evaluation, especially in patients with familial adenomatous polyposis (FAP). Because of the risk of progression to adenocarcinoma, ampullary adenomas should be treated. Endoscopic therapy is an appropriate option and recent e...

journal_title：Current opinion in gastroenterology

authors： Wong RF,DiSario JA

更新日期：2004-09-01 00:00:00

abstract：:Therapeutic biliary endoscopy continues to evolve. Key articles this year primarily involve biliary stenting and biliary stone removal, the two important maneuvers available to the biliary endoscopist. The issues addressed in this review include follow-up after the use of multiple stents for benign strictures, unilate...

journal_title：Current opinion in gastroenterology

authors： Barnett JL

更新日期：2002-05-01 00:00:00

abstract：:Over the last year, several interesting studies have been published on the treatment of esophageal carcinoma. Surprisingly, none of them was a randomized phase III trial. The debate on the necessary extent of a potentially curative surgical resection is ongoing. After initially disappointing results, the innovative te...

journal_title：Current opinion in gastroenterology

authors： van Lanschot JJ,González González D,Richel DJ

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is an increasingly recognized clinical condition. Our objective is to provide a concise review of the advances in the past year in our understanding of AIP. RECENT FINDINGS:In a hospital survey from Japan, the prevalence of AIP was estimated at 0.82 per 100,000 individua...

journal_title：Current opinion in gastroenterology

authors： Pannala R,Chari ST

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapy for inflammatory bowel diseases (IBD) has changed dramatically in recent years with a wider use of immunomodulators and the introduction of antitumor necrosis factor (anti-TNF) agents. This article reviews the existing data on the long-term efficacy of biologics, that is, anti-TNF agents, for ...

journal_title：Current opinion in gastroenterology

authors： Sokol H,Seksik P,Cosnes J

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With recent advances in radiographic testing, there have been increases in the incidental identification of pancreatic cysts. Determining management, specifically, which cysts can be watched versus intervened upon has significant impact on at the patient-physician level as well as globally on resource...

journal_title：Current opinion in gastroenterology

authors： Harrison JM,Castillo CF

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperplastic polyps, once considered to have no malignant potential, are now recognized to be part of a larger group of polyps known as serrated polyps. Serrated polyps can progress to CRC through an epigenetic pathway known as CpG Island Methylator Phenotype (CIMP), characterized by hypermethylation ...

journal_title：Current opinion in gastroenterology

authors： Lindholm CR,Anderson JC,Srivastava A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The gastroduodenum has multiple means by which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal anti-inflammatory drugs, and Helicobacter pylori. We review recent insights into the mechanisms by which the gastroduodenum resists injury and discuss factors con...

journal_title：Current opinion in gastroenterology

authors： Nayeb-Hashemi H,Kaunitz JD

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in our understanding of lymphoid tissue development has led to an appreciation of the variety of these structures in the intestinal mucosa. This knowledge has translated into more critical analysis of the function of mucosal lymphoid tissues and may lead to manipulation of development of thes...

journal_title：Current opinion in gastroenterology

authors： Newberry RD

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS:The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing tha...

journal_title：Current opinion in gastroenterology

authors： Hyun JJ,Kozarek RA

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Endoscopic ampullectomy has proven its safety and efficacy in multiple studies, making it the favorable option for the management of endoscopic ampullectomy. In this review, we plan to review the basic steps every endoscopist should be familiar with before undertaking endoscopic ampullectomy. RECENT ...

journal_title：Current opinion in gastroenterology

authors： Klair JS,Irani S,Kozarek R

更新日期：2020-09-01 00:00:00